登録情報 | データベース: PDB / ID: 6w38 |
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タイトル | Crystal structure of the FAM46C/Plk4 complex |
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要素 | - Serine/threonine-protein kinase PLK4
- Terminal nucleotidyltransferase 5C
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キーワード | TRANSFERASE / RNA polymerase |
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機能・相同性 | 機能・相同性情報
de novo centriole assembly involved in multi-ciliated epithelial cell differentiation / procentriole / deuterosome / procentriole replication complex / positive regulation of centriole replication / trophoblast giant cell differentiation / polo kinase / XY body / polynucleotide adenylyltransferase / poly(A) RNA polymerase activity ...de novo centriole assembly involved in multi-ciliated epithelial cell differentiation / procentriole / deuterosome / procentriole replication complex / positive regulation of centriole replication / trophoblast giant cell differentiation / polo kinase / XY body / polynucleotide adenylyltransferase / poly(A) RNA polymerase activity / mRNA stabilization / negative regulation of cell differentiation / centriole replication / cleavage furrow / cilium assembly / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of mitotic centrosome proteins and complexes / Recruitment of NuMA to mitotic centrosomes / Anchoring of the basal body to the plasma membrane / centriole / AURKA Activation by TPX2 / mitotic spindle organization / kinetochore / spindle pole / Regulation of PLK1 Activity at G2/M Transition / in utero embryonic development / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / nucleolus / RNA binding / nucleoplasm / ATP binding / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Terminal nucleotidyltransferase / Domain of unknown function (DUF1693) / Nucleotidyltransferase / Serine/threonine-protein kinase, first cryptic polo-box domain superfamily / : / Cryptic Polo-Box 1 (CPB1) domain profile. / Cryptic Polo-Box 2 (CPB2) domain profile. / Plk4, C-terminal polo-box domain / Plk4, second cryptic polo-box domain / Plk4, first cryptic polo-box domain ...Terminal nucleotidyltransferase / Domain of unknown function (DUF1693) / Nucleotidyltransferase / Serine/threonine-protein kinase, first cryptic polo-box domain superfamily / : / Cryptic Polo-Box 1 (CPB1) domain profile. / Cryptic Polo-Box 2 (CPB2) domain profile. / Plk4, C-terminal polo-box domain / Plk4, second cryptic polo-box domain / Plk4, first cryptic polo-box domain / Polo-like Kinase 4 Polo Box 1 / Polo-like Kinase 4 Polo Box 2 / POLO box domain / POLO box domain profile. / Tyrosine-protein kinase, active site / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Serine/threonine-protein kinase PLK4 / Terminal nucleotidyltransferase 5C類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 4.48 Å |
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データ登録者 | Chen, H. / Lu, D.F. / Shang, G.J. / Zhang, X.W. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | 1R01CA220283 | 米国 | Robert A. Welch Foundation | i-1702 | 米国 |
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引用 | ジャーナル: Structure / 年: 2020 タイトル: Structural and Functional Analyses of the FAM46C/Plk4 Complex. 著者: Chen, H. / Lu, D. / Shang, G. / Gao, G. / Zhang, X. |
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履歴 | 登録 | 2020年3月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年5月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年6月3日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2020年8月19日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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