Entry | Database: PDB / ID: 6vie |
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Title | Structure of caspase-1 in complex with gasdermin D |
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Components | - Caspase-1 subunit p10
- Caspase-1 subunit p20
- Gasdermin-D
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Keywords | IMMUNE SYSTEM / dual site recognition |
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Function / homology | Function and homology information
Release of apoptotic factors from the mitochondria / Pyroptosis / Regulation of TLR by endogenous ligand / Interleukin-1 processing / caspase-1 / protease inhibitor complex / AIM2 inflammasome complex assembly / The AIM2 inflammasome / pore complex assembly / The IPAF inflammasome ...Release of apoptotic factors from the mitochondria / Pyroptosis / Regulation of TLR by endogenous ligand / Interleukin-1 processing / caspase-1 / protease inhibitor complex / AIM2 inflammasome complex assembly / The AIM2 inflammasome / pore complex assembly / The IPAF inflammasome / AIM2 inflammasome complex / IPAF inflammasome complex / icosanoid biosynthetic process / NLRP1 inflammasome complex / cytokine precursor processing / canonical inflammasome complex / positive regulation of interleukin-18 production / : / wide pore channel activity / NLRP3 inflammasome complex / CARD domain binding / caspase binding / cardiolipin binding / phosphatidic acid binding / positive regulation of tumor necrosis factor-mediated signaling pathway / Interleukin-1 processing / osmosensory signaling pathway / Interleukin-37 signaling / phosphatidylinositol-4-phosphate binding / pattern recognition receptor signaling pathway / : / signaling receptor ligand precursor processing / TP53 Regulates Transcription of Caspase Activators and Caspases / phosphatidylserine binding / pyroptotic inflammatory response / cysteine-type endopeptidase activator activity involved in apoptotic process / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / The NLRP3 inflammasome / protein autoprocessing / protein maturation / protein secretion / Pyroptosis / Purinergic signaling in leishmaniasis infection / phosphatidylinositol-4,5-bisphosphate binding / Neutrophil degranulation / positive regulation of interleukin-1 beta production / mitochondrial membrane / NOD1/2 Signaling Pathway / protein homooligomerization / kinase binding / cellular response to type II interferon / positive regulation of inflammatory response / cellular response to mechanical stimulus / SARS-CoV-1 activates/modulates innate immune responses / regulation of inflammatory response / cellular response to lipopolysaccharide / regulation of apoptotic process / positive regulation of canonical NF-kappaB signal transduction / defense response to Gram-negative bacterium / microtubule / defense response to virus / endopeptidase activity / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / cysteine-type endopeptidase activity / innate immune response / apoptotic process / nucleolus / signal transduction / protein-containing complex / proteolysis / extracellular space / nucleoplasm / identical protein binding / plasma membrane / cytoplasm / cytosolSimilarity search - Function Gasdermin, PUB domain / Gasdermin PUB domain / Gasdermin, pore forming domain / Gasdermin pore forming domain / Caspase recruitment domain / Caspase-like / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site ...Gasdermin, PUB domain / Gasdermin PUB domain / Gasdermin, pore forming domain / Gasdermin pore forming domain / Caspase recruitment domain / Caspase-like / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / Death-like domain superfamily / Alpha-Beta Plaits / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human)
![](img/tx_mammal.gif) Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.4 Å |
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Authors | Liu, Z. / Xiao, T.S. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM127609 | United States |
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Citation | Journal: Immunity / Year: 2020 Title: Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Authors: Liu, Z. / Wang, C. / Yang, J. / Chen, Y. / Zhou, B. / Abbott, D.W. / Xiao, T.S. |
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History | Deposition | Jan 13, 2020 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jul 1, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 29, 2020 | Group: Database references / Category: citation / Item: _citation.journal_volume / _citation.page_first |
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Revision 1.2 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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