+Open data
-Basic information
Entry | Database: PDB / ID: 6vie | ||||||
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Title | Structure of caspase-1 in complex with gasdermin D | ||||||
Components |
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Keywords | IMMUNE SYSTEM / dual site recognition | ||||||
Function / homology | Function and homology information Release of apoptotic factors from the mitochondria / Pyroptosis / Regulation of TLR by endogenous ligand / caspase-1 / protease inhibitor complex / Interleukin-1 processing / AIM2 inflammasome complex assembly / The AIM2 inflammasome / AIM2 inflammasome complex / IPAF inflammasome complex ...Release of apoptotic factors from the mitochondria / Pyroptosis / Regulation of TLR by endogenous ligand / caspase-1 / protease inhibitor complex / Interleukin-1 processing / AIM2 inflammasome complex assembly / The AIM2 inflammasome / AIM2 inflammasome complex / IPAF inflammasome complex / The IPAF inflammasome / NLRP1 inflammasome complex / icosanoid biosynthetic process / cytokine precursor processing / pore complex assembly / canonical inflammasome complex / : / positive regulation of interleukin-18 production / wide pore channel activity / NLRP3 inflammasome complex / positive regulation of interleukin-1 production / caspase binding / osmosensory signaling pathway / CARD domain binding / cardiolipin binding / phosphatidic acid binding / positive regulation of tumor necrosis factor-mediated signaling pathway / Interleukin-1 processing / Interleukin-37 signaling / phosphatidylinositol-4-phosphate binding / pattern recognition receptor signaling pathway / cellular response to organic substance / phosphatidylserine binding / signaling receptor ligand precursor processing / TP53 Regulates Transcription of Caspase Activators and Caspases / pyroptosis / cysteine-type endopeptidase activator activity involved in apoptotic process / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / protein autoprocessing / protein maturation / The NLRP3 inflammasome / protein secretion / Pyroptosis / Purinergic signaling in leishmaniasis infection / phosphatidylinositol-4,5-bisphosphate binding / Neutrophil degranulation / positive regulation of interleukin-1 beta production / mitochondrial membrane / NOD1/2 Signaling Pathway / protein homooligomerization / kinase binding / positive regulation of inflammatory response / cellular response to type II interferon / cellular response to mechanical stimulus / SARS-CoV-1 activates/modulates innate immune responses / regulation of inflammatory response / defense response to virus / regulation of apoptotic process / positive regulation of canonical NF-kappaB signal transduction / endopeptidase activity / cellular response to lipopolysaccharide / defense response to Gram-negative bacterium / microtubule / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / cysteine-type endopeptidase activity / innate immune response / apoptotic process / nucleolus / signal transduction / protein-containing complex / proteolysis / extracellular space / nucleoplasm / membrane / identical protein binding / plasma membrane / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) Mus musculus (house mouse) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.4 Å | ||||||
Authors | Liu, Z. / Xiao, T.S. | ||||||
Funding support | United States, 1items
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Citation | Journal: Immunity / Year: 2020 Title: Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Authors: Liu, Z. / Wang, C. / Yang, J. / Chen, Y. / Zhou, B. / Abbott, D.W. / Xiao, T.S. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6vie.cif.gz | 483.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6vie.ent.gz | 358.5 KB | Display | PDB format |
PDBx/mmJSON format | 6vie.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/vi/6vie ftp://data.pdbj.org/pub/pdb/validation_reports/vi/6vie | HTTPS FTP |
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-Related structure data
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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