+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 6vie | ||||||
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タイトル | Structure of caspase-1 in complex with gasdermin D | ||||||
要素 |
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キーワード | IMMUNE SYSTEM (免疫系) / dual site recognition | ||||||
機能・相同性 | 機能・相同性情報 Release of apoptotic factors from the mitochondria / Pyroptosis / Regulation of TLR by endogenous ligand / Interleukin-1 processing / カスパーゼ-1 / protease inhibitor complex / AIM2 inflammasome complex assembly / The AIM2 inflammasome / AIM2 inflammasome complex / IPAF inflammasome complex ...Release of apoptotic factors from the mitochondria / Pyroptosis / Regulation of TLR by endogenous ligand / Interleukin-1 processing / カスパーゼ-1 / protease inhibitor complex / AIM2 inflammasome complex assembly / The AIM2 inflammasome / AIM2 inflammasome complex / IPAF inflammasome complex / The IPAF inflammasome / NLRP1 inflammasome complex / icosanoid biosynthetic process / cytokine precursor processing / pore complex assembly / canonical inflammasome complex / : / positive regulation of interleukin-18 production / wide pore channel activity / NLRP3 inflammasome complex / positive regulation of interleukin-1 production / caspase binding / CARD domain binding / cardiolipin binding / osmosensory signaling pathway / phosphatidic acid binding / positive regulation of tumor necrosis factor-mediated signaling pathway / Interleukin-1 processing / phosphatidylinositol-4-phosphate binding / Interleukin-37 signaling / pattern recognition receptor signaling pathway / cellular response to organic substance / phosphatidylserine binding / signaling receptor ligand precursor processing / TP53 Regulates Transcription of Caspase Activators and Caspases / pyroptotic inflammatory response / cysteine-type endopeptidase activator activity involved in apoptotic process / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / protein maturation / The NLRP3 inflammasome / protein autoprocessing / protein secretion / Pyroptosis / Purinergic signaling in leishmaniasis infection / phosphatidylinositol-4,5-bisphosphate binding / Neutrophil degranulation / positive regulation of interleukin-1 beta production / ミトコンドリア / NOD1/2 Signaling Pathway / protein homooligomerization / kinase binding / positive regulation of inflammatory response / cellular response to type II interferon / cellular response to mechanical stimulus / SARS-CoV-1 activates/modulates innate immune responses / regulation of inflammatory response / regulation of apoptotic process / defense response to virus / positive regulation of canonical NF-kappaB signal transduction / endopeptidase activity / cellular response to lipopolysaccharide / defense response to Gram-negative bacterium / 微小管 / defense response to Gram-positive bacterium / defense response to bacterium / 炎症 / cysteine-type endopeptidase activity / 自然免疫系 / apoptotic process / 核小体 / シグナル伝達 / protein-containing complex / タンパク質分解 / extracellular space / 核質 / 生体膜 / identical protein binding / 細胞膜 / 細胞質基質 / 細胞質 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) Mus musculus (ハツカネズミ) | ||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.4 Å | ||||||
データ登録者 | Liu, Z. / Xiao, T.S. | ||||||
資金援助 | 米国, 1件
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引用 | ジャーナル: Immunity / 年: 2020 タイトル: Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. 著者: Liu, Z. / Wang, C. / Yang, J. / Chen, Y. / Zhou, B. / Abbott, D.W. / Xiao, T.S. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 6vie.cif.gz | 483.2 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb6vie.ent.gz | 358.5 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 6vie.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/vi/6vie ftp://data.pdbj.org/pub/pdb/validation_reports/vi/6vie | HTTPS FTP |
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-関連構造データ
-リンク
-集合体
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非結晶学的対称性 (NCS) | NCSドメイン:
NCSドメイン領域: Ens-ID: 1
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