Entry | Database: PDB / ID: 6utl |
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Title | Yeast Thiol Specific antoxidant 2 with C171S mutation and catalytic cysteine alkylated with iodoacetamide |
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Components | Peroxiredoxin TSA2 |
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Keywords | OXIDOREDUCTASE / Peroxiredoxin / 2-Cys Prx / Peroxidase / Iodoacetamide |
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Function / homology | Function and homology information
TP53 Regulates Metabolic Genes / Detoxification of Reactive Oxygen Species / peroxiredoxin activity / thioredoxin-dependent peroxiredoxin / thioredoxin peroxidase activity / Neutrophil degranulation / cell redox homeostasis / hydrogen peroxide catabolic process / protein folding / cellular response to heat ...TP53 Regulates Metabolic Genes / Detoxification of Reactive Oxygen Species / peroxiredoxin activity / thioredoxin-dependent peroxiredoxin / thioredoxin peroxidase activity / Neutrophil degranulation / cell redox homeostasis / hydrogen peroxide catabolic process / protein folding / cellular response to heat / cellular response to oxidative stress / response to oxidative stress / protein stabilization / cytosol / cytoplasmSimilarity search - Function Peroxiredoxin, AhpC-type / : / Peroxiredoxin, C-terminal / C-terminal domain of 1-Cys peroxiredoxin / Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant / AhpC/TSA family / Thioredoxin domain profile. / Thioredoxin domain / Thioredoxin-like superfamilySimilarity search - Domain/homology |
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Biological species |  Saccharomyces cerevisiae (brewer's yeast) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.6 Å |
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Authors | Tairum, C.A. / Bannitz-Fernandes, R. / Tonoli, C.C.C. / Murakami, M.T. / de Oliveira, M.A. / Netto, L.E.S. |
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Funding support | Brazil, 1items Organization | Grant number | Country |
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Fundacao para a Ciencia e a Tecnologia | 13/07937-8 | Brazil |
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Citation | Journal: Free Radic Biol Med / Year: 2020 Title: Reduction of sulfenic acids by ascorbate in proteins, connecting thiol-dependent to alternative redox pathways. Authors: Anschau, V. / Ferrer-Sueta, G. / Aleixo-Silva, R.L. / Bannitz Fernandes, R. / Tairum, C.A. / Tonoli, C.C.C. / Murakami, M.T. / de Oliveira, M.A. / Netto, L.E.S. |
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History | Deposition | Oct 29, 2019 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jul 15, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 5, 2020 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.name |
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Revision 1.2 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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