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Open data
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Basic information
Entry | Database: PDB / ID: 6unp | ||||||
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Title | Crystal structure of the kinase domain of BMPR2-D485G | ||||||
![]() | Bone morphogenetic protein receptor type-2 | ||||||
![]() | TRANSFERASE / Kinase | ||||||
Function / homology | ![]() semi-lunar valve development / activin receptor activity, type II / negative regulation of chondrocyte proliferation / lymphatic endothelial cell differentiation / regulation of lung blood pressure / pulmonary valve development / tricuspid valve morphogenesis / chondrocyte development / negative regulation of cell proliferation involved in heart valve morphogenesis / venous blood vessel development ...semi-lunar valve development / activin receptor activity, type II / negative regulation of chondrocyte proliferation / lymphatic endothelial cell differentiation / regulation of lung blood pressure / pulmonary valve development / tricuspid valve morphogenesis / chondrocyte development / negative regulation of cell proliferation involved in heart valve morphogenesis / venous blood vessel development / aortic valve development / BMP binding / proteoglycan biosynthetic process / negative regulation of muscle cell differentiation / atrial septum morphogenesis / endocardial cushion development / maternal placenta development / positive regulation of cartilage development / endochondral bone morphogenesis / transforming growth factor beta receptor activity / lung vasculature development / lymphangiogenesis / mitral valve morphogenesis / retina vasculature development in camera-type eye / BMP receptor activity / positive regulation of axon extension involved in axon guidance / artery development / receptor protein serine/threonine kinase / Signaling by BMP / cellular response to BMP stimulus / endothelial cell apoptotic process / positive regulation of ossification / negative regulation of systemic arterial blood pressure / limb development / endothelial cell proliferation / anterior/posterior pattern specification / cell surface receptor protein serine/threonine kinase signaling pathway / negative regulation of vasoconstriction / ventricular septum morphogenesis / lung alveolus development / positive regulation of epithelial cell migration / blood vessel development / outflow tract morphogenesis / growth factor binding / positive regulation of SMAD protein signal transduction / mesoderm formation / blood vessel remodeling / BMP signaling pathway / positive regulation of bone mineralization / positive regulation of osteoblast differentiation / clathrin-coated pit / cellular response to starvation / protein tyrosine kinase binding / basal plasma membrane / caveola / adherens junction / negative regulation of smooth muscle cell proliferation / negative regulation of cell growth / cellular response to growth factor stimulus / osteoblast differentiation / regulation of cell population proliferation / postsynaptic density / receptor complex / cadherin binding / apical plasma membrane / phosphorylation / axon / neuronal cell body / dendrite / positive regulation of gene expression / cell surface / positive regulation of transcription by RNA polymerase II / extracellular space / nucleoplasm / ATP binding / metal ion binding / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Agnew, C. / Jura, N. | ||||||
![]() | ![]() Title: Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization. Authors: Agnew, C. / Ayaz, P. / Kashima, R. / Loving, H.S. / Ghatpande, P. / Kung, J.E. / Underbakke, E.S. / Shan, Y. / Shaw, D.E. / Hata, A. / Jura, N. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 321.2 KB | Display | ![]() |
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PDB format | ![]() | 215.5 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 1.4 MB | Display | ![]() |
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Full document | ![]() | 1.4 MB | Display | |
Data in XML | ![]() | 24.5 KB | Display | |
Data in CIF | ![]() | 33.7 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 6unqC ![]() 6unrC ![]() 6unsC ![]() 3g2fS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Assembly
Deposited unit | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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