Entry Database : PDB / ID : 3zep Structure visualization Downloads & linksTitle Crystal Structure of JAK3 Kinase Domain in Complex with a Pyrrolopyrazine-2-phenyl Ether Inhibitor ComponentsTYROSINE-PROTEIN KINASE JAK3 Details Keywords TRANSFERASE / STAT5 / STAT6 / INTERLEUKIN-2 / COMMON-GAMMA CHAIN / ATP SITE KINASE INHIBITOR / CANCER / SCID / SEVERE COMBINED IMMUNODEFICIENCYFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of dendritic cell cytokine production / negative regulation of FasL production / response to interleukin-9 / response to interleukin-2 / response to interleukin-15 / response to interleukin-4 / negative regulation of T-helper 1 cell differentiation / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway ... negative regulation of dendritic cell cytokine production / negative regulation of FasL production / response to interleukin-9 / response to interleukin-2 / response to interleukin-15 / response to interleukin-4 / negative regulation of T-helper 1 cell differentiation / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / interleukin-4-mediated signaling pathway / negative regulation of T cell activation / interleukin-2-mediated signaling pathway / regulation of T cell apoptotic process / negative regulation of interleukin-12 production / interleukin-15-mediated signaling pathway / tyrosine phosphorylation of STAT protein / negative regulation of thymocyte apoptotic process / Interleukin-15 signaling / Interleukin-2 signaling / regulation of receptor signaling pathway via JAK-STAT / growth hormone receptor binding / extrinsic component of plasma membrane / Signaling by ALK / Interleukin-20 family signaling / negative regulation of interleukin-10 production / enzyme-linked receptor protein signaling pathway / T cell homeostasis / extrinsic component of cytoplasmic side of plasma membrane / cell surface receptor signaling pathway via JAK-STAT / growth hormone receptor signaling pathway via JAK-STAT / Interleukin receptor SHC signaling / Interleukin-7 signaling / B cell differentiation / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / peptidyl-tyrosine phosphorylation / cytokine-mediated signaling pathway / RAF/MAP kinase cascade / protein phosphatase binding / protein tyrosine kinase activity / Potential therapeutics for SARS / Interleukin-4 and Interleukin-13 signaling / regulation of apoptotic process / adaptive immune response / endosome / cell differentiation / cytoskeleton / intracellular signal transduction / protein phosphorylation / innate immune response / ATP binding / plasma membrane / cytosol Similarity search - Function Tyrosine-protein kinase, non-receptor Jak3 / : / Tyrosine-protein kinase, non-receptor Jak/Tyk2 / JAK, FERM F2 lobe domain / FERM F1 lobe ubiquitin-like domain / JAK1-3/TYK2, pleckstrin homology-like domain / Jak1 pleckstrin homology-like domain / FERM F2 acyl-CoA binding protein-like domain / FERM F1 ubiquitin-like domain / FERM domain ... Tyrosine-protein kinase, non-receptor Jak3 / : / Tyrosine-protein kinase, non-receptor Jak/Tyk2 / JAK, FERM F2 lobe domain / FERM F1 lobe ubiquitin-like domain / JAK1-3/TYK2, pleckstrin homology-like domain / Jak1 pleckstrin homology-like domain / FERM F2 acyl-CoA binding protein-like domain / FERM F1 ubiquitin-like domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Src homology 2 domains / SH2 domain / SH2 domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / PH-like domain superfamily / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.35 Å DetailsAuthors Kuglstatter, A. / Jestel, A. / Nagel, S. / Boettcher, J. / Blaesse, M. CitationJournal : Bioorg.Med.Chem.Lett. / Year : 2013Title : Discovery of a Series of Novel 5H-Pyrrolo[2,3-B]Pyrazine-2-Phenyl Ethers, as Potent Jak3 Kinase Inhibitors.Authors : Jaime-Figueroa, S. / De Vicente, J. / Hermann, J. / Jahangir, A. / Jin, S. / Kuglstatter, A. / Lynch, S.M. / Menke, J. / Niu, L. / Patel, V. / Shao, A. / Soth, M. / Vu, M.D. / Yee, C. History Deposition Dec 6, 2012 Deposition site : PDBE / Processing site : PDBERevision 1.0 Dec 11, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Sep 14, 2016 Group : Database references
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