Entry | Database: PDB / ID: 6u77 |
---|
Title | yGsy2p in complex with small molecule |
---|
Components | Glycogen [starch] synthase isoform 2 |
---|
Keywords | TRANSFERASE/INHIBITOR / Inhibitor / Glycogen Synthase / TRANSFERASE / TRANSFERASE-INHIBITOR complex |
---|
Function / homology | Function and homology information
Glycogen synthesis / glycogen(starch) synthase / glycogen (starch) synthase activity / glycogen biosynthetic process / molecular function inhibitor activity / identical protein binding / nucleus / cytoplasmSimilarity search - Function |
---|
Biological species | ![](img/tx_yeast.gif) Saccharomyces cerevisiae (brewer's yeast) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.85 Å |
---|
Authors | Tang, B. / Hurley, T.D. |
---|
Funding support | United States, 1items Organization | Grant number | Country |
---|
National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | R01-DK079887 | United States |
|
---|
Citation | Journal: J.Med.Chem. / Year: 2020 Title: Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. Authors: Tang, B. / Frasinyuk, M.S. / Chikwana, V.M. / Mahalingan, K.K. / Morgan, C.A. / Segvich, D.M. / Bondarenko, S.P. / Mrug, G.P. / Wyrebek, P. / Watt, D.S. / DePaoli-Roach, A.A. / Roach, P.J. / Hurley, T.D. |
---|
History | Deposition | Aug 31, 2019 | Deposition site: RCSB / Processing site: RCSB |
---|
Revision 1.0 | Mar 18, 2020 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Apr 22, 2020 | Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title |
---|
Revision 1.2 | Jul 29, 2020 | Group: Data collection / Derived calculations / Structure summary Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_site / struct_site_gen Item: _chem_comp.mon_nstd_flag / _chem_comp.name ..._chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
---|
Revision 1.3 | Oct 11, 2023 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
---|
|
---|