登録情報 データベース : PDB / ID : 6s22 構造の表示 ダウンロードとリンクタイトル Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and FGF23c 要素Fibroblast growth factor 23 Polypeptide N-acetylgalactosaminyltransferase 詳細キーワード TRANSFERASE / GalNAc-Ts / GalNAc-T3 / long-range glycosylation preference / (glyco)peptides / Molecular dynamics / specificity / enzyme kinetics / FGF23 / phosphate homeostasis機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
protein O-linked glycosylation via threonine / type 1 fibroblast growth factor receptor binding / polypeptide N-acetylgalactosaminyltransferase / polypeptide N-acetylgalactosaminyltransferase activity / FGFRL1 modulation of FGFR1 signaling / positive regulation of vitamin D 24-hydroxylase activity / negative regulation of hormone secretion / FGFR1c and Klotho ligand binding and activation / regulation of phosphate transport / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway ... protein O-linked glycosylation via threonine / type 1 fibroblast growth factor receptor binding / polypeptide N-acetylgalactosaminyltransferase / polypeptide N-acetylgalactosaminyltransferase activity / FGFRL1 modulation of FGFR1 signaling / positive regulation of vitamin D 24-hydroxylase activity / negative regulation of hormone secretion / FGFR1c and Klotho ligand binding and activation / regulation of phosphate transport / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / intracellular phosphate ion homeostasis / vitamin D catabolic process / response to sodium phosphate / phosphate ion homeostasis / negative regulation of bone mineralization / Signaling by activated point mutants of FGFR3 / FGFR3c ligand binding and activation / Phospholipase C-mediated cascade; FGFR3 / cellular response to vitamin D / FGFR2c ligand binding and activation / Activated point mutants of FGFR2 / Phospholipase C-mediated cascade; FGFR2 / FGFR4 ligand binding and activation / Phospholipase C-mediated cascade; FGFR4 / Signaling by activated point mutants of FGFR1 / FGFR1c ligand binding and activation / Downstream signaling of activated FGFR1 / Phospholipase C-mediated cascade: FGFR1 / cellular response to leptin stimulus / cellular response to interleukin-6 / cellular response to parathyroid hormone stimulus / PI-3K cascade:FGFR3 / PI-3K cascade:FGFR2 / PI-3K cascade:FGFR4 / PI-3K cascade:FGFR1 / response to magnesium ion / PI3K Cascade / fibroblast growth factor receptor signaling pathway / negative regulation of osteoblast differentiation / calcium ion homeostasis / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / FRS-mediated FGFR3 signaling / FRS-mediated FGFR2 signaling / FRS-mediated FGFR4 signaling / regulation of cell migration / Signaling by FGFR3 in disease / FRS-mediated FGFR1 signaling / Signaling by FGFR2 in disease / ERK1 and ERK2 cascade / Signaling by FGFR1 in disease / Negative regulation of FGFR3 signaling / Negative regulation of FGFR2 signaling / Negative regulation of FGFR4 signaling / animal organ morphogenesis / Post-translational protein phosphorylation / Negative regulation of FGFR1 signaling / growth factor activity / Golgi lumen / Constitutive Signaling by Aberrant PI3K in Cancer / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / PIP3 activates AKT signaling / manganese ion binding / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / carbohydrate binding / positive regulation of ERK1 and ERK2 cascade / cell differentiation / positive regulation of protein phosphorylation / endoplasmic reticulum lumen / Golgi membrane / positive regulation of cell population proliferation / positive regulation of gene expression / positive regulation of DNA-templated transcription / extracellular space / extracellular region / cytoplasm 類似検索 - 分子機能 N-acetylgalactosaminyltransferase / Glycosyltransferase 2-like / Glycosyl transferase family 2 / Fibroblast growth factor family / Fibroblast growth factor / Acidic and basic fibroblast growth factor family. / Cytokine IL1/FGF / Ricin-type beta-trefoil lectin domain / Ricin-type beta-trefoil / Lectin domain of ricin B chain profile. ... N-acetylgalactosaminyltransferase / Glycosyltransferase 2-like / Glycosyl transferase family 2 / Fibroblast growth factor family / Fibroblast growth factor / Acidic and basic fibroblast growth factor family. / Cytokine IL1/FGF / Ricin-type beta-trefoil lectin domain / Ricin-type beta-trefoil / Lectin domain of ricin B chain profile. / Ricin B, lectin domain / Ricin B-like lectins / Nucleotide-diphospho-sugar transferases 類似検索 - ドメイン・相同性 : / 2-acetamido-2-deoxy-beta-D-galactopyranose / URIDINE-5'-DIPHOSPHATE / Polypeptide N-acetylgalactosaminyltransferase 3 / Fibroblast growth factor 23 類似検索 - 構成要素生物種 Taeniopygia guttata (キンカチョウ)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.96 Å 詳細データ登録者 de las Rivas, M. / Daniel, E.J.P. / Narimatsu, Y. / Companon, I. / Kato, K. / Hermosilla, P. / Thureau, A. / Ceballos-Laita, L. / Coelho, H. / Bernado, P. ...de las Rivas, M. / Daniel, E.J.P. / Narimatsu, Y. / Companon, I. / Kato, K. / Hermosilla, P. / Thureau, A. / Ceballos-Laita, L. / Coelho, H. / Bernado, P. / Marcelo, F. / Hansen, L. / Lostao, A. / Corzana, F. / Clausen, H. / Gerken, T.A. / Hurtado-Guerrero, R. 引用ジャーナル : Nat.Chem.Biol. / 年 : 2020タイトル : Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.著者: de Las Rivas, M. / Paul Daniel, E.J. / Narimatsu, Y. / Companon, I. / Kato, K. / Hermosilla, P. / Thureau, A. / Ceballos-Laita, L. / Coelho, H. / Bernado, P. / Marcelo, F. / Hansen, L. / ... 著者 : de Las Rivas, M. / Paul Daniel, E.J. / Narimatsu, Y. / Companon, I. / Kato, K. / Hermosilla, P. / Thureau, A. / Ceballos-Laita, L. / Coelho, H. / Bernado, P. / Marcelo, F. / Hansen, L. / Maeda, R. / Lostao, A. / Corzana, F. / Clausen, H. / Gerken, T.A. / Hurtado-Guerrero, R. 履歴 登録 2019年6月20日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2019年12月25日 Provider : repository / タイプ : Initial release改定 1.1 2020年1月22日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ... _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2020年3月4日 Group : Data collection / Database references / カテゴリ : chem_comp / citation / citation_authorItem : _chem_comp.type / _citation.journal_volume ... _chem_comp.type / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID 改定 1.3 2020年7月29日 Group : Data collection / Derived calculations / Structure summaryカテゴリ : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_conn_type / struct_site / struct_site_gen Item : _chem_comp.name / _entity.pdbx_description ... _chem_comp.name / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 1.4 2024年1月24日 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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