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Structure paper

TitleMolecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.
Journal, issue, pagesNat. Chem. Biol., Vol. 16, Page 351-360, Year 2020
Publish dateJun 20, 2019 (structure data deposition date)
Authorsde Las Rivas, M. / Paul Daniel, E.J. / Narimatsu, Y. / Companon, I. / Kato, K. / Hermosilla, P. / Thureau, A. / Ceballos-Laita, L. / Coelho, H. / Bernado, P. ...de Las Rivas, M. / Paul Daniel, E.J. / Narimatsu, Y. / Companon, I. / Kato, K. / Hermosilla, P. / Thureau, A. / Ceballos-Laita, L. / Coelho, H. / Bernado, P. / Marcelo, F. / Hansen, L. / Maeda, R. / Lostao, A. / Corzana, F. / Clausen, H. / Gerken, T.A. / Hurtado-Guerrero, R.
External linksNat. Chem. Biol. / PubMed:31932717
MethodsX-ray diffraction
Resolution1.96 - 2.12 Å
Structure data

PDB-6s22:
Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and FGF23c
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-6s24:
Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and the peptide 3
Method: X-RAY DIFFRACTION / Resolution: 2.12 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-UDP:
URIDINE-5'-DIPHOSPHATE / UDP*YM

ChemComp-MN:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-NGA:
2-acetamido-2-deoxy-beta-D-galactopyranose

ChemComp-HOH:
WATER

ChemComp-TAM:
TRIS(HYDROXYETHYL)AMINOMETHANE / pH buffer*YM

ChemComp-PO4:
PHOSPHATE ION

Source
  • taeniopygia guttata (zebra finch)
  • homo sapiens (human)
KeywordsTRANSFERASE / GalNAc-Ts / GalNAc-T3 / long-range glycosylation preference / (glyco)peptides / Molecular dynamics / specificity / enzyme kinetics / FGF23 / phosphate homeostasis

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