Entry Database : PDB / ID : 6h0b Structure visualization Downloads & linksTitle Crystal structure of the human GalNAc-T4 in complex with UDP, manganese and the diglycopeptide 6. ComponentsALA-THR-GLY-ALA-GLY-ALA-GLY-ALA-GLY-THR-THR-PRO-GLY-PRO-GLY Polypeptide N-acetylgalactosaminyltransferase 4 DetailsKeywords TRANSFERASE / GalNAc-Ts / GalNAc-T4 / short-range glycosylation preference / long-range glycosylation preference / (glyco)peptides / STD-NMR / Molecular dynamics / enzyme kineticsFunction / homology Function and homology informationFunction Domain/homology Component
protein O-linked glycosylation via threonine / protein O-linked glycosylation via serine / polypeptide N-acetylgalactosaminyltransferase / polypeptide N-acetylgalactosaminyltransferase activity / O-glycan processing / O-linked glycosylation of mucins / protein O-linked glycosylation / manganese ion binding / carbohydrate binding / Golgi membrane ... protein O-linked glycosylation via threonine / protein O-linked glycosylation via serine / polypeptide N-acetylgalactosaminyltransferase / polypeptide N-acetylgalactosaminyltransferase activity / O-glycan processing / O-linked glycosylation of mucins / protein O-linked glycosylation / manganese ion binding / carbohydrate binding / Golgi membrane / perinuclear region of cytoplasm / extracellular exosome Similarity search - Function N-acetylgalactosaminyltransferase / Glycosyltransferase 2-like / Glycosyl transferase family 2 / Ricin-type beta-trefoil lectin domain / Ricin-type beta-trefoil / Lectin domain of ricin B chain profile. / Ricin B, lectin domain / Ricin B-like lectins / Nucleotide-diphospho-sugar transferases Similarity search - Domain/homology : / 2-acetamido-2-deoxy-beta-D-galactopyranose / URIDINE-5'-DIPHOSPHATE / Polypeptide N-acetylgalactosaminyltransferase 4 Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.8 Å DetailsAuthors de las Rivas, M. / Daniel, E.J.P. / Coelho, H. / Lira-Navarrete, E. / Raich, L. / Companon, I. / Diniz, A. / Lagartera, L. / Jimenez-Barbero, J. / Clausen, H. ...de las Rivas, M. / Daniel, E.J.P. / Coelho, H. / Lira-Navarrete, E. / Raich, L. / Companon, I. / Diniz, A. / Lagartera, L. / Jimenez-Barbero, J. / Clausen, H. / Rovira, C. / Marcelo, F. / Corzana, F. / Gerken, T.A. / Hurtado-Guerrero, R. CitationJournal : ACS Cent Sci / Year : 2018Title : Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.Authors: de Las Rivas, M. / Paul Daniel, E.J. / Coelho, H. / Lira-Navarrete, E. / Raich, L. / Companon, I. / Diniz, A. / Lagartera, L. / Jimenez-Barbero, J. / Clausen, H. / Rovira, C. / Marcelo, F. / ... Authors : de Las Rivas, M. / Paul Daniel, E.J. / Coelho, H. / Lira-Navarrete, E. / Raich, L. / Companon, I. / Diniz, A. / Lagartera, L. / Jimenez-Barbero, J. / Clausen, H. / Rovira, C. / Marcelo, F. / Corzana, F. / Gerken, T.A. / Hurtado-Guerrero, R. History Deposition Jul 8, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 10, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Jul 29, 2020 Group : Data collection / Derived calculations / Structure summaryCategory : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_struct_conn_angle / struct_conn / struct_conn_type / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 1.2 Jan 17, 2024 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
Show all Show less