Entry | Database: PDB / ID: 6rpn |
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Title | Structure of metallo beta lactamase VIM-2 with cyclic boronate APC308. |
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Components | Beta-lactamase VIM-2 |
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Keywords | ANTIMICROBIAL PROTEIN / beta lactamases / antimicrobial resistance / cyclic boronate |
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Function / homology | Function and homology information
: / Metallo-beta-lactamase superfamily / Metallo-beta-lactamase superfamily / Metallo-beta-lactamase / Ribonuclease Z/Hydroxyacylglutathione hydrolase-likeSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Pseudomonas aeruginosa (bacteria) |
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Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 1.409 Å |
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Authors | Parkova, A. / Lucic, A. / Brem, J. / McDonough, M.A. / Langley, G.W. / Schofield, C.J. |
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Funding support | United Kingdom, 1items Organization | Grant number | Country |
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Medical Research Council (United Kingdom) | | United Kingdom |
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Citation | Journal: Acs Infect Dis. / Year: 2020 Title: Broad Spectrum beta-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate. Authors: Parkova, A. / Lucic, A. / Krajnc, A. / Brem, J. / Calvopina, K. / Langley, G.W. / McDonough, M.A. / Trapencieris, P. / Schofield, C.J. |
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History | Deposition | May 14, 2019 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Mar 25, 2020 | Provider: repository / Type: Initial release |
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Revision 2.0 | Apr 15, 2020 | Group: Non-polymer description / Refinement description / Category: chem_comp / refine / Item: _chem_comp.formula / _refine.pdbx_diffrn_id |
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Revision 2.1 | Jun 24, 2020 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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Revision 2.2 | Jan 24, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_alt_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr2_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_alt_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_ptnr1_label_alt_id / _struct_conn.pdbx_ptnr2_label_alt_id / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_symmetry |
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