PDB-6r2e: Crystal structure of the human thymidylate synthase (hTS) interfa...

Basic information

• Entry: Database: PDB / ID: 6r2e
• Title: Crystal structure of the human thymidylate synthase (hTS) interface variant Q62R
• Components: (Thymidylate synthase) x 2
• Keywords: TRANSFERASE / human thymidylate synthase / folate pathway / Q62R / interface variant

Function / homology

Function:

thymidylate synthase / Interconversion of nucleotide di- and triphosphates / sequence-specific mRNA binding / folic acid binding / thymidylate synthase activity / tetrahydrofolate interconversion / dTMP biosynthetic process / dTTP biosynthetic process / DNA biosynthetic process / G1/S-Specific Transcription / mRNA regulatory element binding translation repressor activity / methylation / mitochondrial inner membrane / negative regulation of translation / mitochondrial matrix / mitochondrion / nucleus / cytoplasm / cytosol

Domain/homology:

Thymidylate Synthase; Chain A / Thymidylate synthase/dCMP hydroxymethylase domain / Thymidylate synthase, active site / Thymidylate synthase active site. / Thymidylate synthase / Thymidylate synthase/dCMP hydroxymethylase / Thymidylate synthase/dCMP hydroxymethylase domain / Thymidylate synthase/dCMP hydroxymethylase superfamily / Thymidylate synthase / 2-Layer Sandwich / Alpha Beta

Component:

Chem-FFO / Thymidylate synthase

• Biological species: Homo sapiens (human)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.55 Å
• Authors: Pozzi, C. / Mangani, M.

Funding support

Italy, 1items

Organization	Grant number	Country
Italian Association for Cancer Research	AIRC IG16977	Italy

• Citation: Journal: Biomolecules / Year: 2019; Title: Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R.; Authors: Pozzi, C. / Lopresti, L. / Santucci, M. / Costi, M.P. / Mangani, S.

History

Deposition	Mar 16, 2019	Deposition site: PDBE / Processing site: PDBE
Revision 1.0	Apr 10, 2019	Provider: repository / Type: Initial release
Revision 1.1	Apr 24, 2019	Group: Data collection / Database references / Category: citation / citation_author / pdbx_database_proc Item: _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID
Revision 1.2	Jan 24, 2024	Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model Item: _citation.country / _database_2.pdbx_DOI / _database_2.pdbx_database_accession

Assembly

Deposited unit

A: Thymidylate synthase

C: Thymidylate synthase

D: Thymidylate synthase

B: Thymidylate synthase

F: Thymidylate synthase

H: Thymidylate synthase

E: Thymidylate synthase

G: Thymidylate synthase

hetero molecules

Summary:

• 305 kDa, 8 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	304,626	43
Polymers	298,738	8
Non-polymers	5,888	35
Water	43,776	2430

1

A: Thymidylate synthase

B: Thymidylate synthase

hetero molecules

Summary:

• defined by software
• Evidence: gel filtration
• 76.1 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	76,137	11
Polymers	74,700	2
Non-polymers	1,437	9
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	7440 Å2
ΔGint	-109 kcal/mol
Surface area	22030 Å2
Method	PISA

2

C: Thymidylate synthase

D: Thymidylate synthase

hetero molecules

Summary:

• defined by software
• 76.3 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	76,325	13
Polymers	74,700	2
Non-polymers	1,626	11
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	7530 Å2
ΔGint	-110 kcal/mol
Surface area	22060 Å2
Method	PISA

3

F: Thymidylate synthase

E: Thymidylate synthase

hetero molecules

Summary:

• defined by software
• 76 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	76,036	9
Polymers	74,669	2
Non-polymers	1,367	7
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	7010 Å2
ΔGint	-83 kcal/mol
Surface area	21970 Å2
Method	PISA

4

H: Thymidylate synthase

G: Thymidylate synthase

hetero molecules

Summary:

• defined by software
• 76.1 kDa, 2 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	76,128	10
Polymers	74,669	2
Non-polymers	1,459	8
Water	36	2

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	6870 Å2
ΔGint	-74 kcal/mol
Surface area	22060 Å2
Method	PISA

Unit cell

Length a, b, c (Å)	139.939, 167.070, 189.970
Angle α, β, γ (deg.)	90.00, 90.00, 90.00
Int Tables number	18
Space group name H-M	P21221

Components

Protein , 2 types, 8 molecules A C D B F H E G

#1: Protein

A C D B F H
Thymidylate synthase / TSase

Details:

Mass: 37349.754 Da / Num. of mol.: 6 / Mutation: Q62R
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: TYMS, TS, OK/SW-cl.29 / Plasmid: pQE80L / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P04818, thymidylate synthase

#2: Protein

E G Thymidylate synthase / TSase

Details:

Mass: 37319.730 Da / Num. of mol.: 2 / Mutation: Q62R
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: TYMS, TS, OK/SW-cl.29 / Plasmid: pQE80L / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P04818, thymidylate synthase

Non-polymers , 5 types, 2465 molecules

#3: Chemical

A-401 A-402 C-401 C-402 C-403 D-401 D-402 B-401 B-402 F-401 F-402 H-401 H-402 E-401 E-402 G-401 G-402
ChemComp-SO4 / SULFATE ION

Details:

Mass: 96.063 Da / Num. of mol.: 17 / Source method: obtained synthetically / Formula: SO₄

#4: Chemical

A-403 C-404 D-403 B-403 F-403 H-403 E-403 G-403
ChemComp-FFO / N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid / [6S]-5-FORMYL-TETRAHYDROFOLATE / 6S-FOLINIC ACID

Details:

Mass: 473.439 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: C₂₀H₂₃N₇O₇

#5: Chemical

A-404 A-405 C-405 D-405 D-406 B-404 E-404 G-404
ChemComp-CL / CHLORIDE ION

Details:

Mass: 35.453 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: Cl

#6: Chemical

D-404 H-404 ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL

Details:

Mass: 92.094 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₃H₈O₃

#7: Water

ChemComp-HOH / water

Details:

Mass: 18.015 Da / Num. of mol.: 2430 / Source method: isolated from a natural source / Formula: H₂O

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 4.18 ų/Da / Density % sol: 70.56 %
• Crystal grow: Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 9 / Details: 2.0-2.2 M ammonium sulfate, 0.1 M bicine pH 9.0

Data collection

• Diffraction: Mean temperature: 100 K / Serial crystal experiment: N
• Diffraction source: Source: SYNCHROTRON / Site: ESRF / Beamline: ID30B / Wavelength: 0.96861 Å
• Detector: Type: DECTRIS PILATUS3 6M / Detector: PIXEL / Date: Feb 16, 2017
• Radiation: Monochromator: Si(111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 0.96861 Å / Relative weight: 1
• Reflection: Resolution: 2.55→94.99 Å / Num. obs: 145044 / % possible obs: 99.9 % / Observed criterion σ(I): 2 / Redundancy: 5.9 % / B_iso Wilson estimate: 26.83 Ų / CC_1/2: 0.993 / R_merge(I) obs: 0.163 / R_pim(I) all: 0.072 / R_rim(I) all: 0.178 / Net I/σ(I): 6.9
• Reflection shell: Resolution: 2.55→2.69 Å / Redundancy: 5.3 % / R_merge(I) obs: 0.704 / Mean I/σ(I) obs: 2.1 / Num. unique obs: 20911 / CC_1/2: 0.83 / R_pim(I) all: 0.334 / R_rim(I) all: 0.782 / % possible all: 99.6

Processing

Software

Name	Version	Classification
REFMAC	5.8.0238	refinement
XDS		data reduction
SCALA		data scaling
MOLREP		phasing

Refinement

Method to determine structure: MOLECULAR REPLACEMENT
Starting model: 1HVY

1hvy

Resolution: 2.55→94.99 Å / Cor.coef. F_o:F_c: 0.958 / Cor.coef. F_o:F_c free: 0.927 / SU B: 16.576 / SU ML: 0.198 / Cross valid method: THROUGHOUT / ESU R: 0.326 / ESU R Free: 0.264

	Rfactor	Num. reflection	% reflection	Selection details
Rfree	0.25834	7182	5 %	RANDOM
Rwork	0.19643	-	-	-
obs	0.19948	137694	99.79 %	-

• Solvent computation: Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å

Displacement parameters

B_iso mean: 44.012 Ų

	Baniso -1	Baniso -2	Baniso -3
1-	-0.24 Å2	0 Å2	0 Å2
2-	-	0.24 Å2	0 Å2
3-	-	-	0.01 Å2

• Refine analyze: Luzzati coordinate error obs: 0.334 Å

Refinement step

Cycle: LAST / Resolution: 2.55→94.99 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	18544	0	377	2430	21351

Refine LS restraints

Refine-ID	Type	Dev ideal	Dev ideal target	Number
X-RAY DIFFRACTION	r_bond_refined_d	0.012	0.012	19397
X-RAY DIFFRACTION	r_bond_other_d
X-RAY DIFFRACTION	r_angle_refined_deg	2.167	1.642	26260
X-RAY DIFFRACTION	r_angle_other_deg
X-RAY DIFFRACTION	r_dihedral_angle_1_deg	7.798	5	2299
X-RAY DIFFRACTION	r_dihedral_angle_2_deg	33.608	21.086	1077
X-RAY DIFFRACTION	r_dihedral_angle_3_deg	19.373	15	3195
X-RAY DIFFRACTION	r_dihedral_angle_4_deg	21.415	15	158
X-RAY DIFFRACTION	r_chiral_restr	0.148	0.2	2386
X-RAY DIFFRACTION	r_gen_planes_refined	0.01	0.02	15076
X-RAY DIFFRACTION	r_gen_planes_other
X-RAY DIFFRACTION	r_nbd_refined
X-RAY DIFFRACTION	r_nbd_other
X-RAY DIFFRACTION	r_nbtor_refined
X-RAY DIFFRACTION	r_nbtor_other
X-RAY DIFFRACTION	r_xyhbond_nbd_refined
X-RAY DIFFRACTION	r_xyhbond_nbd_other
X-RAY DIFFRACTION	r_metal_ion_refined
X-RAY DIFFRACTION	r_metal_ion_other
X-RAY DIFFRACTION	r_symmetry_vdw_refined
X-RAY DIFFRACTION	r_symmetry_vdw_other
X-RAY DIFFRACTION	r_symmetry_hbond_refined
X-RAY DIFFRACTION	r_symmetry_hbond_other
X-RAY DIFFRACTION	r_symmetry_metal_ion_refined
X-RAY DIFFRACTION	r_symmetry_metal_ion_other
X-RAY DIFFRACTION	r_mcbond_it	2.153	1.73	9238
X-RAY DIFFRACTION	r_mcbond_other
X-RAY DIFFRACTION	r_mcangle_it	3.518	2.576	11520
X-RAY DIFFRACTION	r_mcangle_other
X-RAY DIFFRACTION	r_scbond_it	3.24	2.041	10159
X-RAY DIFFRACTION	r_scbond_other
X-RAY DIFFRACTION	r_scangle_it
X-RAY DIFFRACTION	r_scangle_other
X-RAY DIFFRACTION	r_long_range_B_refined	8.655	24.249	29808
X-RAY DIFFRACTION	r_long_range_B_other
X-RAY DIFFRACTION	r_rigid_bond_restr
X-RAY DIFFRACTION	r_sphericity_free
X-RAY DIFFRACTION	r_sphericity_bonded

LS refinement shell

Resolution: 2.55→2.616 Å / Total num. of bins used: 20

	Rfactor	Num. reflection	% reflection
Rfree	0.389	554	-
Rwork	0.315	10032	-
obs	-	-	99.51 %

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	6.2107	1.6297	4.3208	0.4393	1.0071	4.7323	0.4282	-0.2473	-0.8399	0.1353	-0.0475	-0.2309	-0.201	-0.1302	-0.3807	0.3693	0.0301	-0.0493	0.2701	0.0897	0.3053	53.2685	-28.1364	-14.8441
2	3.3233	2.5368	1.3382	4.5337	2.5384	1.4326	-0.0129	-0.0066	-0.0473	0.2325	0.0139	-0.086	0.1267	-0.0171	-0.001	0.4235	0.0313	-0.0047	0.2162	0.0169	0.2707	43.9725	-33.5306	-23.4272
3	4.3833	2.0194	-4.8395	5.5423	-1.791	5.3938	0.3021	0.6136	-0.08	0.1841	-0.35	0.1413	-0.358	-0.732	0.0479	0.3146	-0.0194	-0.0264	0.2897	0.0026	0.2967	39.7871	-26.2839	-37.5717
4	0.1416	0.5009	-0.1102	1.7997	-0.4061	0.0977	0.049	-0.0086	-0.0127	0.0455	-0.0614	0.0067	0.0377	0.0296	0.0124	0.3841	0.1231	-0.0162	0.2317	-0.0058	0.3032	43.4816	-24.2924	-20.2006
5	10.2422	1.1156	-5.7191	3.7743	-0.0379	3.2875	-0.0208	-0.2252	-0.363	0.1295	-0.1566	-0.2135	0.0278	0.0959	0.1774	0.2368	0.0073	-0.0666	0.3355	0.0535	0.2987	58.2067	-16.657	-9.6152
6	0.2793	0.0513	-0.3962	0.1227	-0.1355	0.6453	0.0203	-0.014	-0.0046	0.0149	-0.1027	-0.0473	-0.0552	0.1805	0.0824	0.2596	-0.0203	-0.0497	0.338	0.0803	0.3201	58.3252	-11.493	-27.2155
7	4.9982	-0.2417	3.2003	0.899	-0.3306	2.3973	0.0676	0.1457	0.2668	-0.1786	0.0051	0.0192	0.0352	0.2198	-0.0727	0.3858	0.0323	0.0591	0.2251	0.0211	0.2653	51.2143	-8.1142	-41.7671
8	1.876	-0.3086	0.9018	0.0565	-0.1445	0.4462	0.0795	-0.1306	0.054	-0.0118	-0.0372	-0.0326	0.0984	-0.0691	-0.0423	0.4198	-0.0082	-0.0403	0.2578	0.0681	0.2331	46.4057	-1.3464	-31.0815
9	1.4624	-1.0734	-1.4828	0.972	0.144	6.3824	0.1408	0.0036	0.0113	-0.0559	-0.0462	0.0007	-0.4138	0.1395	-0.0946	0.3753	-0.0411	-0.0399	0.2077	0.0546	0.2788	46.2943	6.0499	-32.5661
10	3.0229	1.2512	-0.7542	0.8069	1.1784	7.8773	0.0647	-0.109	-0.2282	-0.068	-0.0551	-0.1036	-0.4865	-0.0332	-0.0097	0.3686	-0.0243	-0.0078	0.2101	-0.0023	0.2866	46.6365	1.9864	-10.2356
11	0.1633	0.2175	0.5288	0.3006	0.7352	1.8375	0.0718	0.0073	-0.0008	0.0409	0.0047	-0.0427	0.0395	-0.0867	-0.0766	0.475	-0.0018	0.0325	0.2415	0.0408	0.2269	38.3202	-3.729	-20.8778
12	0.0522	0.2119	-0.2035	1.1906	0.0133	3.1422	0.005	0.0069	0.0242	0.0118	0.0233	0.0376	0.0151	0.0593	-0.0283	0.3183	-0.0061	0.005	0.3193	0.0664	0.2684	42.0521	-8.472	-28.0656
13	0.4579	0.1612	-0.4484	0.8516	1.0294	2.242	0.0352	-0.0149	0.0126	0.0395	0.0037	0.0083	0.004	0.1176	-0.0389	0.3813	0.0334	-0.0319	0.2612	0.0131	0.2643	46.5299	-14.1403	-16.1986
14	0.2492	0.141	-0.2191	0.6681	0.5804	1.0616	-0.0109	-0.1083	-0.0616	-0.0078	-0.0948	-0.0289	0.0499	0.1145	0.1056	0.3409	0.0486	-0.0188	0.2719	0.0385	0.2969	51.1743	-16.5307	-20.5829
15	9.8684	3.1236	8.6023	3.0152	1.2351	8.5976	0.3802	-0.0781	-0.5455	0.0605	0.028	-0.3004	0.4106	-0.094	-0.4081	0.3276	0.0994	-0.0173	0.2032	0.0253	0.2873	58.5751	-33.0176	-22.3784
16	1.397	-0.2853	-1.8288	0.0599	0.3545	2.6579	0.0031	-0.0936	-0.0423	-0.0027	-0.0022	0.0214	0.0479	0.4399	-0.0009	0.2251	0.0137	-0.0442	0.4105	0.0008	0.3164	64.1882	-16.407	-13.1485
17	4.2311	1.561	0.9164	0.6207	0.4877	0.7032	-0.1489	0.2193	-0.044	-0.176	0.1672	-0.0304	-0.4502	0.3245	-0.0183	0.3969	-0.1653	-0.0281	0.3123	0.0378	0.335	63.2721	0.2207	-14.7556
18	7.8566	4.3516	-0.6284	4.5567	3.539	7.0906	-0.0745	-0.6691	0.1823	-0.3128	0.1796	0.0452	-0.4723	1.0329	-0.1051	0.3114	-0.0963	0.0176	0.2688	0.0557	0.2641	61.8909	0.2912	-20.5587
19	0.4293	0.133	-0.344	5.295	2.9888	2.1525	-0.008	-0.2012	-0.0985	0.1649	0.094	-0.1664	0.0862	0.3454	-0.086	0.2226	0.0312	-0.0709	0.3643	0.0167	0.3375	66.885	-16.8524	-18.7494
20	8.487	-5.3712	1.4214	4.316	-1.1977	0.3391	0.0643	0.6934	-0.1182	-0.2632	-0.1481	-0.1885	0.0964	0.0465	0.0838	0.2867	0.0013	0.0651	0.2964	-0.0164	0.2316	56.5287	-24.6993	-35.033
21	1.7376	2.1914	-2.502	2.8062	-3.1837	3.6217	-0.0928	0.0363	0.0009	-0.2427	0.1248	0.0807	0.2384	-0.0827	-0.032	0.4636	-0.0225	-0.0846	0.1806	0.041	0.3355	30.1126	-26.9839	-4.3917
22	7.9473	3.3612	6.1093	4.5917	4.8233	6.281	0.2736	-0.0631	-0.2791	-0.0009	0.0626	-0.3025	0.1119	-0.0107	-0.3362	0.3663	-0.0243	-0.0151	0.2573	0.0398	0.261	36.8548	-19.3504	2.2493
23	0.1644	-0.283	-0.358	1.8914	0.405	1.0953	-0.0638	-0.1359	-0.0537	-0.174	0.0626	0.2714	-0.1422	0.334	0.0012	0.4155	0.0319	0.0138	0.2062	0.0321	0.2562	37.4307	-6.3213	0.6586
24	6.0541	3.1164	-1.1882	5.1392	-2.5169	1.264	0.2255	0.5668	0.2739	0.1472	-0.2694	-0.0541	-0.0421	0.1746	0.0439	0.2077	0.0229	0.0015	0.2779	0.0422	0.2242	33.1252	-23.4569	-12.0197
25	0.7097	-2.0607	-0.8806	8.3272	1.2411	1.8589	-0.0284	-0.1106	-0.1864	0.0064	-0.1157	0.5582	0.0712	0.3513	0.1441	0.2993	-0.023	-0.0183	0.2477	0.0123	0.3496	21.5387	-27.5564	-15.6269
26	0.6008	-0.67	0.1484	0.8155	-0.1867	0.0477	0.1202	0.1339	-0.0796	0.0289	-0.1297	0.1267	-0.0263	0.0216	0.0095	0.3781	0.0597	0.023	0.2135	0.0222	0.3289	16.5287	-10.9508	-12.5748
27	1.7687	0.2725	-2.6298	1.3026	0.1066	4.1216	0.1112	0.0389	0.0693	-0.0396	-0.0194	0.1259	-0.2252	-0.0619	-0.0918	0.2963	0.0929	0.0102	0.2644	0.0382	0.3445	13.9132	-1.8132	-11.0583
28	1.9417	2.3031	-1.0217	8.8056	-1.2817	0.5389	0.1393	-0.1588	0.0503	0.0525	-0.1069	0.1162	-0.078	0.0738	-0.0324	0.3592	0.0166	0.0366	0.2309	-0.0141	0.2774	23.9161	8.8737	-7.0612
29	0.4086	0.3406	1.5757	0.3062	1.3455	6.1375	-0.0381	0.046	0.0371	0.0056	0.0553	-0.0536	-0.1389	0.1656	-0.0172	0.3282	0.0439	-0.0053	0.1766	0.0195	0.4288	21.9222	12.1206	-12.9669
30	2.3236	1.2585	0.3279	0.6843	0.1815	0.0594	0.0178	-0.0029	-0.3531	-0.0339	0.0073	-0.1995	-0.0665	-0.0457	-0.0251	0.4713	0.1761	0.0161	0.1948	0.0219	0.2906	25.1821	-0.6751	-22.6891
31	2.5073	2.3519	0.685	3.4578	3.8857	8.7813	-0.3038	0.2383	0.0045	-0.4338	0.282	0.074	-0.43	0.0084	0.0219	0.3625	0.0384	-0.0494	0.2282	0.1174	0.3332	21.5374	8.6339	-23.6901
32	0.1484	0.604	0.7695	3.1595	3.9245	4.9353	0.0883	-0.0583	0.0102	-0.3579	-0.276	0.0753	-0.3915	-0.4878	0.1877	0.4245	0.1118	0.0071	0.3494	0.048	0.1937	22.3953	-1.3679	-30.3491
33	5.9409	2.2327	4.5839	0.8522	1.7356	3.5511	-0.1643	0.4127	-0.132	-0.129	0.1869	0.0042	-0.2164	0.3031	-0.0225	0.3852	0.0764	-0.1587	0.2392	0.0134	0.2634	26.8619	-17.5143	-34.7994
34	0.1151	0.2507	-0.0804	1.8398	0.7825	0.8994	-0.058	0.0723	0.033	0.0319	0.2445	0.0364	-0.0127	0.0133	-0.1865	0.3559	0.0554	-0.0008	0.2409	0.0124	0.3039	31.9229	-9.9101	-22.7232
35	0.1253	0.0269	0.1587	0.0141	0.06	0.9832	0.094	0.025	0.0945	0.0299	-0.0381	0.0159	0.0276	-0.1024	-0.0558	0.3665	0.0345	-0.0075	0.2369	-0.0021	0.2998	26.8642	-16.2925	-10.9643
36	1.1357	-0.6205	-0.3876	0.5328	0.3089	0.1821	0.0161	0.0137	0.1206	0.2293	-0.0601	0.0949	0.1284	-0.05	0.044	0.4972	-0.1501	0.0106	0.2022	-0.0025	0.2906	19.403	-27.4643	-2.3926
37	1.9492	-0.0074	0.069	0.817	2.4478	7.349	0.2349	0.3336	-0.2366	0.0771	-0.1325	-0.03	0.2214	-0.3148	-0.1024	0.1885	-0.0372	-0.1034	0.3771	-0.0087	0.3401	9.548	-22.7107	-22.9334
38	4.6427	-2.0016	-3.6652	0.8642	1.5827	2.9004	0.1819	0.1747	0.1884	-0.0682	-0.0605	-0.0748	-0.1192	-0.12	-0.1214	0.2262	0.0354	-0.0407	0.3295	0.0477	0.2928	13.7704	-13.5512	-30.1253
39	1.7939	1.9421	0.2275	5.9703	-4.7439	6.6798	0.1379	-0.0962	0.0131	-0.1596	0.1697	0.405	0.3235	-0.6034	-0.3075	0.2162	0.0769	-0.0435	0.3824	-0.1132	0.3166	10.0808	-19.501	-16.4597
40	2.6939	3.9768	0.1849	7.6916	0.3042	0.0278	0.1537	-0.19	0.0289	0.0629	-0.1696	0.0567	-0.0388	-0.0565	0.0159	0.314	0.0195	0.0118	0.269	0.0041	0.2902	19.748	-12.1786	1.9008
41	6.677	1.4503	-4.7073	0.3173	-1.0078	5.1345	0.4141	-0.2266	0.493	0.0923	-0.0398	0.0838	0.1589	-0.0348	-0.3743	0.3235	-0.0059	-0.0002	0.1965	-0.0592	0.3199	86.509	-55.3406	-25.2026
42	5.3108	3.2357	-1.5968	3.0771	-1.7951	1.0935	0.1583	-0.4499	0.3947	-0.3008	-0.172	0.0986	0.251	0.0832	0.0137	0.4228	-0.0032	0.0426	0.1884	-0.0226	0.2871	94.289	-51.5209	-33.5243
43	5.3903	1.3853	-0.791	0.3578	-0.2022	0.1304	-0.0831	0.5028	-0.0585	-0.0106	0.1209	-0.0326	0.0093	-0.0141	-0.0378	0.2591	0.0138	0.0092	0.3396	-0.09	0.2756	100.5602	-53.5673	-42.8301
44	0.334	-0.0737	-0.5869	0.6203	0.1695	1.057	0.049	-0.0268	0.0665	0.0033	-0.0109	0.0691	-0.1082	0.0206	-0.0382	0.3453	0.0557	0.0156	0.2613	-0.0006	0.298	96.2638	-59.2235	-33.6947
45	7.5583	-1.085	6.6378	2.532	-4.9156	12.4624	-0.1007	-0.0691	0.2627	0.1078	0.1291	0.1404	-0.1588	-0.2346	-0.0284	0.3363	0.0601	0.0759	0.2748	-0.026	0.2707	81.6414	-66.8693	-19.9614
46	0.4644	0.054	0.0417	0.0081	0.0095	0.0198	-0.0112	0.0998	-0.0123	0.0101	-0.007	0.013	0.0063	-0.0563	0.0182	0.3502	0.0296	0.027	0.3055	-0.041	0.2742	81.4324	-72.0864	-37.456
47	1.5998	-0.2159	-2.9031	0.0339	0.3764	5.3404	0.0188	0.2592	-0.0858	-0.0138	-0.0779	0.0237	-0.0748	-0.3418	0.0591	0.3153	-0.0211	-0.0387	0.3259	-0.0886	0.2696	80.5083	-75.0193	-45.2622
48	7.4869	-2.6859	-0.9558	4.3566	1.415	0.4621	0.1852	0.1108	-0.1224	-0.3377	-0.1723	-0.0189	-0.1292	-0.0597	-0.0128	0.4285	0.0465	0.0154	0.2774	-0.0592	0.1586	92.7562	-75.2509	-55.684
49	1.1081	0.2924	-1.2007	0.0838	-0.3227	1.3069	-0.0489	0.0297	-0.0093	0.0115	0.0446	0.0103	0.0446	-0.0737	0.0043	0.4098	-0.0053	0.0092	0.3297	-0.0286	0.2002	93.0679	-82.2579	-42.3818
50	0.6759	-0.7841	0.9231	1.3319	0.2778	5.7404	0.1767	-0.0648	-0.079	-0.1546	0.1095	0.044	0.1414	-0.0121	-0.2862	0.3671	-0.0594	0.0326	0.2392	-0.0878	0.2778	93.4226	-89.6555	-42.9327
51	2.205	-0.1667	3.0119	0.0133	-0.2576	10.7633	-0.0951	-0.0787	-0.2331	0.0074	-0.0034	0.0076	0.1052	-0.1568	0.0985	0.3393	-0.0218	0.0258	0.2379	-0.0119	0.3077	93.291	-85.5229	-20.5475
52	0.1856	0.2957	-0.5426	0.4772	-0.8777	1.6157	0.0542	0.0097	-0.0113	0.0927	-0.0227	0.0084	-0.1671	0.0506	-0.0315	0.435	0.0446	0.0283	0.2627	-0.0929	0.2401	100.7428	-78.7427	-36.8393
53	0.4684	0.161	-0.0385	0.1246	-0.0078	0.0063	0.0501	-0.1138	-0.1259	-0.0302	-0.0529	0.0734	-0.0348	0.0244	0.0027	0.4	-0.0283	0.0182	0.3037	-0.0349	0.2762	94.1331	-74.1275	-24.1168
54	0.2649	-0.0864	0.2005	0.1014	-0.0011	0.2145	0.0288	-0.0104	-0.0003	-0.0498	-0.0658	0.0435	-0.041	-0.0381	0.037	0.3451	0.0199	0.0347	0.2834	-0.0071	0.2897	89.7917	-69.8848	-28.4627
55	5.5729	-1.6003	-3.2156	0.5075	1.2472	4.3095	0.138	0.1563	-0.014	-0.111	-0.0352	0.021	-0.3847	0.0147	-0.1029	0.3728	0.0424	-0.0365	0.1912	0.0255	0.3129	88.9585	-52.5383	-41.5484
56	8.0712	-1.0327	-5.1967	4.8272	-5.3728	15.34	0.2847	-0.2561	0.319	0.2291	-0.2325	-0.0929	-0.3047	0.2316	-0.0521	0.2693	0.0239	0.0048	0.1937	-0.0589	0.3002	78.7302	-50.3169	-30.0655
57	0.4041	1.347	-0.6282	4.6985	-2.2117	1.0484	0.0127	-0.0403	0.0962	-0.1022	0.0588	0.1782	0.0361	-0.0732	-0.0716	0.2382	-0.0209	0.0471	0.3331	-0.0632	0.3808	74.7575	-72.4414	-23.7042
58	5.4126	-3.202	-0.4044	2.5615	-1.5345	4.7817	0.1238	-0.0482	-0.4199	-0.2693	0.0315	0.3325	0.4817	-0.106	-0.1553	0.3293	-0.0497	0.012	0.2525	-0.0308	0.2932	78.1251	-84.1046	-29.8804
59	0.0709	0.0579	0.0038	4.9811	-2.9936	1.8224	-0.1189	-0.1079	0.0543	-0.3326	0.139	0.1181	0.1518	-0.1471	-0.0201	0.3563	0.0929	0.0298	0.2677	-0.0365	0.3641	73.8424	-63.8995	-31.024
60	10.8612	-5.9768	-3.4495	6.2793	3.6169	3.1925	0.1789	0.6037	0.0145	-0.2874	-0.1876	0.0744	-0.0973	-0.2565	0.0088	0.3038	0.0161	-0.0252	0.3032	-0.0035	0.2552	86.8651	-60.6735	-47.9178
61	3.8195	2.9342	1.4776	7.7938	-0.8548	1.2895	0.1336	0.0519	0.1995	-0.0973	-0.1152	0.3644	0.1174	0.097	-0.0184	0.4025	-0.0446	0.0617	0.2239	-0.0296	0.2717	110.3261	-56.9167	-15.0505
62	3.1774	0.8999	-1.21	0.273	-0.5796	4.9734	-0.1961	-0.0982	0.4885	-0.0796	0.0071	0.128	0.4227	0.1513	0.189	0.315	-0.0039	0.0262	0.3018	0.0334	0.277	105.3827	-62.9191	-10.1389
63	1.81	2.9332	2.0015	7.2631	1.2097	3.8632	0.0766	0.0465	0.0795	0.1551	-0.0057	0.3118	0.0734	0.0977	-0.0709	0.3153	-0.0039	0.0085	0.2789	0.0076	0.2669	100.1817	-71.3105	-6.4443
64	2.1071	0.3087	-1.5329	2.5441	-2.1941	2.6685	0.0587	-0.2168	-0.0813	0.1191	0.1079	0.2809	-0.1479	0.052	-0.1666	0.4006	-0.0658	-0.1066	0.1805	-0.0534	0.2021	103.7496	-73.945	-13.4002
65	3.0977	4.6372	-0.7308	7.4919	-1.3954	0.3382	-0.0306	-0.0419	0.0533	0.3955	-0.0877	-0.1787	-0.2378	0.0107	0.1183	0.4451	0.0027	-0.0583	0.2684	0.0097	0.3415	114.888	-55.39	-25.9052
66	0.1857	-0.4209	0.1281	1.1944	-0.1641	0.2807	0.052	0.0327	0.0067	-0.0877	-0.0554	-0.0302	-0.0089	0.2132	0.0034	0.2687	0.0315	0.0116	0.3209	-0.0139	0.3137	123.2068	-72.2977	-23.0678
67	2.2396	1.0288	-0.0943	2.7079	-0.1854	0.0221	0.055	0.1621	-0.1602	0.2971	-0.0073	-0.1863	0.013	0.0088	-0.0478	0.4172	0.0451	-0.089	0.1845	-0.0204	0.3119	120.9194	-86.7333	-19.4351
68	5.0068	1.6369	-2.8565	3.9854	-0.0561	5.5156	-0.1373	0.7894	-0.6995	0.0677	0.3394	0.0233	0.1765	0.4025	-0.2021	0.2343	0.0561	0.0234	0.349	-0.2182	0.2976	118.2355	-94.2642	-23.9504
69	1.4487	1.5785	-1.9156	2.2674	-1.3527	3.5343	-0.0696	-0.1187	0.0963	0.0004	-0.0443	0.248	0.1734	0.3012	0.1138	0.3526	0.062	0.0106	0.2299	-0.0216	0.3367	114.0342	-83.55	-34.4589
70	3.4045	3.1866	1.0844	7.6099	-5.8532	10.5537	-0.1415	-0.0093	0.0897	-0.7683	-0.2552	-0.1927	0.9629	0.3523	0.3967	0.34	0.0957	0.058	0.2242	-0.0504	0.3156	121.0348	-91.2773	-35.5304
71	0.0412	-0.1443	0.2272	8.8788	-6.0335	4.5483	-0.0802	0.0631	-0.0692	-0.6636	0.2945	-0.1226	0.155	0.0147	-0.2143	0.3236	-0.0547	0.1602	0.3301	-0.133	0.3145	115.4057	-78.6253	-42.2257
72	9.0702	-2.943	-0.852	4.4408	-3.2954	3.7412	0.1188	0.4127	0.1945	-0.184	-0.1408	-0.116	0.1372	-0.0194	0.022	0.294	-0.0168	0.028	0.3142	-0.0185	0.2516	112.9642	-64.8656	-45.3149
73	0.3584	0.1306	0.0633	0.275	-0.1661	0.2138	-0.0385	0.0977	-0.0482	-0.0262	0.1103	-0.0163	0.0202	0.0409	-0.0717	0.3942	0.0567	0.0259	0.2631	-0.0389	0.2544	107.8916	-73.6145	-33.1175
74	0.0231	0.038	0.1005	0.0777	0.2221	0.6857	0.0394	0.0426	-0.0303	0.0473	0.0467	-0.0176	0.0221	0.0812	-0.0861	0.3502	0.0381	0.0174	0.2731	0.0205	0.3045	113.7262	-68.0512	-25.1404
75	0.1117	0.0785	0.0203	0.1117	-0.1461	0.4946	0.0302	0.073	-0.0257	0.0565	0.0255	0.0079	-0.0132	0.0339	-0.0557	0.3585	0.0126	0.0034	0.2678	-0.004	0.2914	111.8036	-67.2433	-19.7332
76	0.3547	-0.3746	-0.0539	2.1017	-0.0333	0.0142	0.2265	0.264	0.121	0.6937	-0.1956	-0.0703	-0.0932	-0.0356	-0.0309	0.7481	0.1437	0.1159	0.2732	0.0675	0.1236	119.0407	-58.3323	-11.1677
77	0.3111	-0.448	1.3939	4.039	-4.4394	8.0774	-0.106	0.0408	0.0498	-0.061	-0.4141	-0.4809	-0.388	0.2766	0.5201	0.1725	0.0257	0.0921	0.4388	0.0223	0.268	130.8463	-61.6313	-34.7207
78	0.3393	0.2144	-1.0896	1.4987	0.4472	4.4512	-0.1361	0.0089	-0.0127	-0.1137	0.1433	-0.0986	0.4045	0.1085	-0.0072	0.2356	0.026	0.0203	0.3512	-0.0231	0.283	128.4048	-70.4835	-36.7664
79	0.9162	0.5023	-2.469	0.2959	-1.4374	7.0451	-0.0904	-0.3258	-0.0716	0.0211	-0.2205	-0.0608	-0.0038	1.1172	0.3109	0.2868	-0.0612	-0.0049	0.3369	0.02	0.3038	127.7445	-61.145	-18.4657
80	10.884	8.6646	7.2159	9.1575	9.2755	10.321	0.3377	-0.152	-0.6289	0.5809	-0.0025	-0.4549	0.6638	0.1474	-0.3352	0.2826	0.0005	-0.0374	0.2847	0.0074	0.3423	117.8876	-76.8439	-8.4349
81	2.7933	0.5902	-3.6049	1.7143	-2.4517	6.4527	0.0238	-0.1021	0.0045	-0.0871	-0.0849	-0.0361	0.0884	0.1931	0.0611	0.4259	-0.0024	-0.0158	0.2273	-0.0243	0.2583	31.0797	-49.8471	-8.619
82	9.3821	0.2035	-5.5953	6.1185	-0.9137	3.4398	0.2184	-0.6582	0.1617	0.0056	-0.104	0.1685	-0.1297	0.4091	-0.1144	0.3318	-0.0255	0.005	0.2896	-0.0037	0.2567	40.1376	-43.4202	-15.7418
83	1.0651	-1.0447	-1.1065	1.0391	1.1083	1.19	0.0721	-0.0279	0.002	-0.1315	0.0156	-0.0534	-0.1766	0.0035	-0.0877	0.4997	-0.0204	0.0291	0.1598	0.0075	0.2593	37.9053	-46.3257	-28.1019
84	4.2002	0.359	-3.4593	1.6405	-1.8833	4.4166	-0.2016	-0.2796	0.1655	0.0212	0.3236	-0.0182	0.1281	-0.0971	-0.1219	0.4039	-0.0036	-0.027	0.3198	-0.0614	0.2637	27.2827	-59.7338	-7.2032
85	0.4124	-0.7316	-0.1934	1.3015	0.3426	0.1288	0.0715	0.0136	-0.0408	-0.1152	-0.0457	0.0629	-0.1347	-0.0815	-0.0258	0.4035	0.1228	-0.0066	0.2734	0.0078	0.2726	16.3805	-52.6907	-17.4408
86	0.8008	-0.7754	-1.3238	0.751	1.2815	2.1961	-0.0001	0.0423	-0.0195	0.0162	-0.0202	0.0135	0.0608	-0.1038	0.0203	0.3233	0.0069	-0.1473	0.3209	0.0388	0.3586	14.1322	-61.4827	-30.6114
87	1.1243	0.0101	-2.2602	1.8956	0.2425	4.6187	0.167	-0.0762	-0.0419	-0.5841	-0.3287	0.3561	-0.41	0.0197	0.1617	0.3659	0.132	-0.1478	0.3191	-0.0299	0.2309	13.3419	-51.7603	-31.5261
88	11.021	-1.2061	-2.2429	0.1595	0.2444	0.4614	0.0981	0.5864	-0.2962	-0.0236	-0.1535	-0.0353	-0.0687	-0.1246	0.0554	0.4584	0.1454	-0.0415	0.3383	0.1129	0.2141	20.5547	-52.2638	-44.9361
89	2.2222	0.4308	0.33	0.0845	0.0695	0.2765	0.0613	0.0784	0.0699	0.0128	0.026	0.0228	0.1079	0.2592	-0.0873	0.3303	0.0434	-0.055	0.3144	-0.0345	0.205	19.1637	-62.5709	-33.7486
90	0.3684	-0.0545	0.9913	1.2206	-1.0022	3.3255	0.0176	-0.1928	-0.0697	-0.3709	0.0324	-0.1149	0.2753	-0.4539	-0.05	0.3349	-0.0031	-0.0665	0.3199	-0.0627	0.257	16.8104	-70.4423	-35.96
91	3.6653	0.1824	3.3445	3.8244	-2.6122	5.2392	0.0266	-0.0255	-0.0971	-0.2907	-0.0437	-0.0075	0.3892	-0.1644	0.0171	0.3348	-0.0843	-0.009	0.2378	-0.0844	0.2827	22.2591	-79.0817	-16.9868
92	0.2271	0.5447	-0.335	1.3624	-0.8405	0.5328	-0.0439	-0.0051	-0.042	0.0527	-0.0371	-0.1103	-0.0679	-0.0424	0.0809	0.4004	0.0846	-0.0641	0.2835	-0.0217	0.2582	28.426	-65.6715	-30.532
93	0.0564	-0.1023	0.2076	0.321	-0.2015	1.1924	0.0409	-0.0227	-0.0272	-0.0882	0.0001	0.1241	-0.0254	0.0265	-0.041	0.3661	0.0159	-0.0195	0.2675	-0.0135	0.2644	27.0695	-61.3686	-17.0862
94	0.5759	0.5375	-0.4415	1.4999	-0.5554	0.38	0.078	0.0433	-0.1033	0.0216	-0.129	-0.0379	-0.1014	-0.062	0.051	0.4053	0.0233	-0.0323	0.2305	-0.0095	0.2512	25.6661	-57.2522	-16.7483
95	2.7187	1.4113	-2.5038	3.5081	-1.4375	4.5704	-0.1137	-0.1403	0.1147	0.1958	-0.0658	-0.1992	-0.2283	-0.003	0.1795	0.4116	0.0628	-0.0506	0.1737	-0.0624	0.2612	26.8912	-40.6468	-9.3562
96	0.7831	-0.8652	0.4967	0.9606	-0.6558	3.5951	-0.0456	-0.1053	0.016	0.0834	0.1502	-0.0191	-0.3977	-0.5558	-0.1046	0.2574	0.0412	0.0095	0.2838	-0.0429	0.3088	15.9292	-56.1242	-6.06
97	9.8807	-4.5402	1.2978	2.1187	-0.587	0.1757	0.1722	-0.1115	-0.5873	-0.1076	-0.0682	0.2815	0.0095	-0.0519	-0.1039	0.2817	0.0136	0.0417	0.4753	0.0004	0.3799	7.3675	-69.0143	-13.5141
98	5.0871	-2.5414	-4.6212	6.5251	1.4188	4.3585	-0.154	0.0394	-0.0811	-0.1287	0.2225	0.8312	0.1805	-0.1303	-0.0685	0.1618	0.0043	-0.0815	0.3201	0.0377	0.3365	7.1942	-63.7646	-17.5745
99	3.2033	6.8315	0.4112	15.1933	2.0754	2.3959	0.0929	0.0318	0.2844	0.2307	-0.0214	0.519	-0.007	-0.167	-0.0715	0.2745	0.0356	0.0016	0.2864	-0.0307	0.2826	14.2385	-48.9929	-7.3316
100	1.7829	-0.6052	-3.0651	3.9867	5.3907	10.2859	0.001	0.2325	0.1972	0.0863	0.1525	0.1421	0.1255	-0.1261	-0.1535	0.3653	0.0793	-0.0776	0.2317	0.0144	0.2848	22.1051	-41.0426	-23.3621
101	6.5418	2.5118	0.5724	3.9398	1.1577	0.3459	-0.1367	-0.0543	0.1946	-0.1416	0.1203	0.0758	-0.0405	0.0456	0.0164	0.3193	-0.0354	-0.0108	0.3123	-0.0435	0.2609	52.7782	-65.4229	-9.7384
102	4.6952	1.5614	-2.5027	8.4434	-0.4812	1.3507	-0.0668	-0.2247	0.0892	0.1818	0.1209	0.193	0.0435	0.1409	-0.0541	0.3283	0.0138	0.0071	0.3133	-0.0363	0.2439	44.0543	-72.2527	-4.9946
103	1.5458	1.3114	-1.5776	1.4919	-1.6031	1.8001	0.0162	-0.2034	-0.0931	-0.0911	0.0417	0.2684	0.1192	0.0992	-0.0578	0.2773	0.0053	0.0373	0.138	0.0718	0.4638	35.2936	-79.8539	-6.6251
104	1.1511	1.0868	-0.5166	1.4802	-0.1733	0.4731	0.0393	-0.1172	0.0455	0.0875	0.0976	-0.0326	0.0164	0.1514	-0.1369	0.3912	-0.0116	-0.0205	0.2347	0.0317	0.2662	40.3657	-72.1921	-12.0858
105	0.4727	-0.1507	0.6927	0.0618	-0.2433	1.0576	0.0607	0.1342	0.0158	0.0382	-0.078	-0.0163	0.0058	0.2852	0.0173	0.379	-0.017	0.0182	0.3128	-0.0372	0.2414	57.4777	-70.1681	-19.7336
106	0.6311	1.2213	-0.4082	2.3847	-0.7998	0.2701	-0.1367	0.1113	-0.1403	-0.205	0.116	-0.2122	0.0589	-0.0482	0.0208	0.3311	0.0258	-0.0327	0.2789	-0.1575	0.3278	49.4037	-78.4382	-33.2689
107	5.0676	-3.7093	2.2213	6.2682	1.6617	4.017	0.0401	0.1832	0.001	0.2788	-0.0235	-0.0391	0.294	0.1653	-0.0166	0.3041	0.0402	0.0202	0.2649	-0.0613	0.2703	51.364	-85.8259	-30.8886
108	6.8666	-0.4509	1.1868	3.7205	3.0663	2.8867	-0.0633	-0.0659	-0.2644	0.204	0.1065	0.0615	0.1579	0.0892	-0.0432	0.3891	-0.0613	-0.0465	0.1343	-0.0632	0.3309	37.6891	-93.1186	-28.9073
109	5.6731	-1.9945	-0.5644	1.4097	1.561	2.6993	0.3991	-0.1265	0.1284	-0.1678	-0.1052	-0.1792	0.018	-0.2532	-0.2939	0.5301	-0.0349	-0.0016	0.1368	-0.0879	0.1944	39.7778	-86.4804	-33.8154
110	1.942	0.6186	-1.2399	2.6914	-0.3031	0.7975	0.116	0.0344	-0.1118	-0.327	-0.2193	-0.0007	-0.0787	-0.0409	0.1033	0.4801	0.0103	-0.0562	0.2007	-0.0978	0.2216	38.5241	-78.6483	-40.8459
111	0.2451	-0.5381	0.2547	1.2735	-0.6301	0.3195	0.0563	0.1601	0.0737	-0.0711	-0.1799	-0.2243	0.0095	0.0364	0.1236	0.3092	0.0796	0.0339	0.4352	-0.074	0.1392	39.9398	-69.1325	-41.5778
112	1.2213	-0.3967	-1.9316	2.8461	1.127	5.7949	0.2789	0.0013	0.1533	-0.2976	-0.179	-0.1121	-0.0246	-0.1899	-0.0999	0.3737	-0.0056	0.01	0.2276	-0.0157	0.2779	43.1446	-56.3942	-38.3544
113	0.3334	0.6537	0.3213	2.0364	0.0914	0.7195	0.0962	0.0367	0.0695	0.0323	-0.0895	0.1469	0.1966	0.1439	-0.0067	0.4173	-0.0005	-0.005	0.2409	-0.0881	0.2529	33.6317	-72.6817	-30.9968
114	0.0137	0.0276	-0.1663	0.057	-0.349	2.1594	0.0195	0.0097	-0.011	0.0208	0.0244	-0.0048	-0.1134	-0.0975	-0.0439	0.4375	-0.0381	0.0098	0.2021	-0.0214	0.2909	44.2593	-60.2269	-26.9272
115	0.1258	-0.0409	-0.1554	0.2437	-0.3719	1.0289	0.0944	-0.0035	-0.0621	-0.02	-0.0602	0.1153	-0.0209	0.1707	-0.0342	0.3656	0.0166	0.0019	0.2603	-0.0251	0.284	46.7978	-70.8851	-20.2616
116	11.6092	6.8479	-0.0048	6.0748	-2.1077	2.1847	0.1615	-0.1146	-0.2005	0.3213	-0.0389	0.0201	-0.2735	0.017	-0.1226	0.3118	-0.0316	-0.0398	0.3224	-0.0315	0.2491	55.9175	-75.8901	-4.0076
117	0.0141	0.1939	-0.0736	2.8015	-1.0456	0.3966	0.0059	-0.0139	-0.012	0.0955	-0.1018	-0.3343	-0.0799	0.0302	0.0959	0.3333	0.018	0.1035	0.3734	-0.053	0.2185	62.2176	-65.955	-25.7247
118	5.1421	-4.0226	4.5348	3.3332	-3.3832	4.1444	0.3113	0.2684	-0.097	-0.4533	-0.0565	-0.1247	0.0871	0.3791	-0.2549	0.3885	-0.0591	0.1971	0.3494	-0.0858	0.2948	56.1844	-69.6256	-39.9729
119	0.7164	-0.1299	-0.3358	2.0535	-1.4695	1.3369	-0.1621	-0.0861	-0.0659	-0.2629	-0.1366	-0.4427	0.3106	0.1808	0.2987	0.249	-0.0042	0.0426	0.3514	-0.0395	0.2789	62.7218	-73.4198	-20.0349
120	9.171	2.2466	-3.464	0.7063	-0.3658	2.8209	-0.2639	-0.0583	-0.061	0.1355	-0.0027	0.0433	0.7125	0.0002	0.2666	0.3564	0.0536	-0.0013	0.1477	-0.0261	0.25	46.9617	-86.9981	-15.7254
121	2.9937	-0.8726	1.5684	5.1005	3.965	4.8591	0.0102	-0.3568	0.2263	-0.0718	-0.0011	-0.2074	-0.0285	-0.2946	-0.0092	0.4494	-0.085	0.0306	0.2461	0.0414	0.2352	108.9446	-33.2927	-18.3037
122	2.9532	1.4938	3.8074	8.6449	4.2554	5.5982	-0.0541	-0.2184	-0.1583	0.2022	0.171	0.1607	0.0056	-0.212	-0.1169	0.3166	-0.0277	0.0191	0.2753	0.0141	0.2795	100.4198	-39.5576	-26.9194
123	2.3176	-0.6751	1.9404	0.2109	-0.5632	1.6262	0.1129	0.1219	-0.1768	-0.0636	0.0087	0.1022	0.045	0.1063	-0.1216	0.5846	-0.0596	-0.0478	0.0701	0.0428	0.221	101.9868	-37.6669	-39.4613
124	2.6384	3.0675	1.1232	10.1709	-0.8563	1.1874	0.1662	-0.0879	-0.1905	0.2482	-0.0187	-0.0049	0.0328	-0.0652	-0.1476	0.3198	0.0067	0.0269	0.2778	0.0053	0.2392	106.5343	-25.7022	-21.9612
125	0.2537	-0.8897	-0.4652	4.0943	1.2072	1.1963	-0.1047	-0.0695	0.0228	0.0483	0.2116	0.0914	0.1236	0.1682	-0.1069	0.3868	0.0152	-0.0087	0.2606	-0.0331	0.2493	119.9883	-30.7404	-20.9414
126	1.7606	0.8637	0.6111	0.431	0.2865	0.2406	0.144	-0.0635	0.2352	0.0566	-0.1269	0.1313	0.1059	0.0716	-0.0171	0.4212	0.1774	0.0849	0.3951	-0.0577	0.2823	126.0023	-24.6032	-36.8062
127	0.4704	0.7101	0.7462	3.0415	-0.8536	3.1782	-0.0248	0.0019	-0.0656	-0.446	-0.0938	-0.2966	0.3398	0.1237	0.1186	0.3614	0.1162	0.1138	0.2625	-0.0019	0.2876	126.238	-32.0081	-42.0251
128	8.5077	-1.4378	3.7942	2.495	0.5799	2.4796	0.5317	0.4739	-0.3302	-0.1393	-0.4064	0.2561	0.384	0.144	-0.1253	0.5212	0.169	0.012	0.2719	-0.052	0.172	117.9553	-32.5393	-55.0016
129	4.2504	1.8249	4.6445	10.0263	2.4788	5.1016	-0.011	0.2145	0.052	-0.1778	-0.0413	-0.0816	-0.0367	0.2276	0.0522	0.2859	0.0398	0.0874	0.2851	0.0582	0.2821	124.3686	-27.8928	-54.3899
130	0.6412	0.253	1.2739	0.1375	0.449	2.6435	0.0162	0.007	-0.0859	-0.0353	0.0952	-0.0939	-0.069	-0.1388	-0.1115	0.4405	0.0425	0.0994	0.2317	0.0035	0.2746	119.0848	-17.1093	-43.1742
131	1.3023	-0.8932	-0.6397	3.2538	-2.2903	3.1378	0.2629	-0.1416	0.145	-0.3143	-0.1189	-0.0311	-0.0159	0.316	-0.1439	0.3007	-0.0508	0.0718	0.3522	0.0433	0.1948	124.0306	-13.8252	-48.3198
132	2.4976	2.2796	2.2076	2.9822	3.0221	3.0783	0.176	-0.135	-0.0533	-0.3145	0.0748	-0.2442	-0.3897	0.0808	-0.2507	0.397	-0.0326	0.0408	0.1972	0.0811	0.3059	118.2162	-5.3422	-28.3131
133	0.3446	0.4943	0.207	0.7313	0.3123	0.1452	-0.0633	-0.0086	0.0282	-0.0109	-0.0104	0.0887	0.02	0.0447	0.0737	0.4529	0.0585	0.0697	0.2523	0.0759	0.2347	111.2296	-17.9084	-41.213
134	0.1473	-0.1617	0.1457	0.1969	-0.1786	0.1666	0.0633	0.0172	0.0776	-0.0601	-0.0656	-0.0328	0.0608	0.0343	0.0023	0.3921	-0.0062	0.0209	0.2503	0.0047	0.2806	114.1043	-21.1778	-26.469
135	0.1915	-0.2148	-0.9511	1.4138	2.0697	5.6554	-0.0599	0.0158	-0.0881	-0.0474	-0.023	-0.1931	0.1084	-0.0621	0.0829	0.3932	0.0185	0.0448	0.1634	0.0313	0.3285	109.2252	-44.3511	-31.1994
136	2.1454	2.3386	0.3556	4.635	-0.4229	0.8409	0.2738	-0.2994	0.1446	0.3066	-0.4177	-0.0147	0.2584	0.0682	0.1439	0.3668	0.025	0.0276	0.2446	0.0504	0.2201	117.2292	-36.911	-16.6187
137	2.938	-2.2568	-0.5597	1.7831	0.4494	0.1344	-0.2278	-0.5364	0.3113	0.0631	0.3716	-0.2568	0.0064	0.0945	-0.1438	0.3235	0.0317	-0.0443	0.3324	-0.0089	0.3558	132.8899	-17.574	-21.0965
138	2.7104	2.8234	-0.5297	2.9832	-0.4988	0.1984	0.0631	0.0531	-0.5311	0.059	0.008	-0.6736	-0.1347	-0.0086	-0.0711	0.2874	0.0038	0.0398	0.2224	-0.0076	0.4763	131.3749	-20.8173	-25.998
139	1.925	-1.1229	1.0088	0.7832	-0.632	0.5441	0.0167	0.1329	-0.1728	0.2148	0.022	0.0242	-0.0658	0.0427	-0.0387	0.4782	0.1412	-0.0158	0.0719	-0.0439	0.2134	122.0157	-40.3741	-20.506
140	9.0837	1.2476	1.7362	0.191	0.2253	0.3568	0.1492	0.3986	-0.2018	0.0214	-0.0211	0.0065	0.0383	0.1149	-0.1281	0.3867	0.0484	-0.0172	0.3216	-0.0879	0.3358	116.0683	-41.4674	-38.4232
141	6.3511	3.7349	-6.3245	2.2546	-3.8434	6.5636	-0.3309	-0.2302	-0.4782	-0.1382	-0.0022	-0.2123	0.2013	-0.0531	0.3331	0.2485	0.0309	0.0624	0.4279	0.1044	0.3636	85.8894	-20.4723	-20.4512
142	2.9237	0.9556	2.6058	0.8845	1.0536	2.402	0.1349	0.009	-0.1053	0.2296	0.0027	-0.1211	0.1422	-0.0353	-0.1376	0.4477	0.0601	0.0529	0.3283	0.0304	0.1908	93.8201	-12.4646	-17.0328
143	2.4796	-0.4251	2.8693	0.1639	-0.494	3.3651	-0.2773	-0.136	0.2648	0.0493	-0.096	-0.1902	-0.435	-0.1671	0.3733	0.3549	0.0061	-0.1068	0.2057	0.1332	0.3905	103.7461	-3.998	-16.4962
144	0.834	1.4431	1.1155	2.5204	1.9647	1.5627	0.1575	-0.1134	0.0189	0.1968	-0.2284	0.0407	0.073	-0.1527	0.0708	0.3747	-0.0329	0.086	0.2214	-0.0028	0.3074	102.8367	-5.712	-20.6073
145	6.2427	1.7917	6.5731	0.6347	1.6583	7.4146	0.0965	-0.1946	0.0691	-0.0903	-0.177	0.0549	0.4481	-0.0038	0.0805	0.3781	0.0065	0.0489	0.2565	0.0666	0.244	89.859	-23.2715	-28.1025
146	0.0292	-0.0594	-0.1081	1.4192	2.327	3.8343	0.0827	-0.0314	0.0438	0.0018	0.059	-0.0482	-0.0078	0.0561	-0.1417	0.3207	-0.0084	0.0052	0.3101	0.0389	0.288	82.0705	-10.5586	-30.7686
147	2.367	2.5945	0.8326	3.5243	1.0816	0.335	-0.2143	0.1992	0.1347	-0.1686	0.1717	0.1473	-0.0542	0.0554	0.0426	0.3955	0.0423	-0.0212	0.268	0.1204	0.2559	91.2713	-4.7179	-44.5624
148	4.7099	1.3398	0.0378	0.8864	0.1462	0.1131	0.1288	0.0943	0.32	-0.0098	-0.0013	0.0039	-0.1263	-0.1029	-0.1274	0.4066	0.1049	0.0478	0.1685	0.1141	0.3408	95.8932	6.3211	-39.6629
149	0.3068	0.2366	1.7324	0.1844	1.3429	9.8423	-0.0819	-0.0434	0.0125	-0.0852	-0.0364	-0.0037	-0.5797	-0.2368	0.1183	0.3153	0.0693	0.0475	0.324	0.0801	0.3327	100.2672	9.6352	-45.9551
150	0.2219	-0.2501	0.1224	1.4607	0.9381	1.0515	0.0269	0.0648	0.0612	-0.1181	-0.1138	0.0071	-0.0491	-0.0153	0.0869	0.4789	-0.0174	-0.0176	0.2117	0.1264	0.2237	100.6561	-6.3713	-50.0106
151	0.796	-1.7203	1.6758	3.7911	-4.0759	7.4371	0.0836	0.0231	-0.1344	-0.0792	-0.0446	0.2254	-0.0297	0.1708	-0.0391	0.4144	-0.0244	-0.0436	0.2156	0.0004	0.2424	96.4316	-27.1332	-48.6634
152	0.0921	0.071	-0.1893	0.0646	-0.1178	0.6476	0.0386	0.0701	-0.0705	0.0419	0.0136	-0.1	-0.2011	-0.1451	-0.0522	0.4643	-0.0111	-0.001	0.2176	0.0711	0.2868	104.9078	-11.096	-40.2286
153	0.5249	-0.226	0.5395	0.1004	-0.2214	0.6653	0.1662	-0.0099	0.0519	-0.0455	-0.0167	-0.0396	0.2162	-0.0283	-0.1494	0.471	-0.0511	-0.0086	0.1887	0.0533	0.3417	96.052	-20.6033	-34.1873
154	0.6583	-0.9127	-0.5334	1.4479	0.3323	1.3565	0.0721	0.1139	-0.0138	-0.0916	-0.1337	-0.0014	-0.1382	-0.2168	0.0616	0.3554	-0.0129	-0.0369	0.2676	0.0085	0.2802	88.1734	-16.7244	-37.7853
155	0.3372	0.4294	0.2477	0.6709	0.4138	0.528	0.0555	-0.0069	0.1079	-0.0287	-0.0624	-0.0097	0.0319	-0.1001	0.0069	0.3248	0.0203	0.0092	0.2599	0.0359	0.3036	89.9734	-10.0239	-21.3908
156	5.8041	-4.9191	-2.2051	4.262	1.7924	0.9021	-0.049	-0.0117	-0.3462	-0.2175	0.0459	0.4471	0.2393	-0.0459	0.0031	0.7731	-0.2289	-0.4303	0.3027	0.0769	0.2756	76.3835	-18.4217	-42.5486
157	0.1563	0.1963	-0.6305	3.6669	-0.5405	2.6073	0.0147	0.0997	0.0908	0.0002	0.3804	-0.0208	-0.1508	-0.3021	-0.3951	0.3363	-0.0031	-0.016	0.4027	0.0053	0.1939	85.9087	-16.8475	-52.0361
158	9.2585	1.7409	-0.8573	0.9704	-1.2074	1.7868	0.0463	0.0066	0.0274	-0.3627	0.4203	0.2908	0.6226	-0.662	-0.4665	0.3824	-0.105	-0.197	0.3969	0.1235	0.2478	80.1053	-12.0352	-46.7112
159	3.8711	1.9972	1.8472	5.074	7.4416	11.3236	-0.0813	0.1114	-0.0172	-0.1402	-0.0345	0.1083	-0.2676	-0.1368	0.1158	0.2794	0.0353	0.0189	0.2776	0.0797	0.318	75.5175	-11.1719	-28.3337
160	13.6345	2.2516	-4.8419	0.3918	-0.8792	2.2891	0.331	0.0593	0.5017	0.0984	-0.0024	0.0993	-0.2578	-0.1885	-0.3286	0.2989	0.0503	-0.0024	0.258	-0.002	0.3145	90.0199	2.5358	-24.9047

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	A	26 - 35
2	X-RAY DIFFRACTION	2	A	36 - 44
3	X-RAY DIFFRACTION	3	A	45 - 53
4	X-RAY DIFFRACTION	4	A	54 - 66
5	X-RAY DIFFRACTION	5	A	67 - 71
6	X-RAY DIFFRACTION	6	A	72 - 99
7	X-RAY DIFFRACTION	7	A	100 - 127
8	X-RAY DIFFRACTION	8	A	128 - 144
9	X-RAY DIFFRACTION	9	A	145 - 160
10	X-RAY DIFFRACTION	10	A	161 - 174
11	X-RAY DIFFRACTION	11	A	175 - 185
12	X-RAY DIFFRACTION	12	A	186 - 201
13	X-RAY DIFFRACTION	13	A	202 - 222
14	X-RAY DIFFRACTION	14	A	223 - 264
15	X-RAY DIFFRACTION	15	A	265 - 275
16	X-RAY DIFFRACTION	16	A	276 - 280
17	X-RAY DIFFRACTION	17	A	281 - 288
18	X-RAY DIFFRACTION	18	A	289 - 293
19	X-RAY DIFFRACTION	19	A	294 - 304
20	X-RAY DIFFRACTION	20	A	305 - 313
21	X-RAY DIFFRACTION	21	B	25 - 35
22	X-RAY DIFFRACTION	22	B	36 - 43
23	X-RAY DIFFRACTION	23	B	44 - 60
24	X-RAY DIFFRACTION	24	B	61 - 65
25	X-RAY DIFFRACTION	25	B	66 - 72
26	X-RAY DIFFRACTION	26	B	73 - 98
27	X-RAY DIFFRACTION	27	B	99 - 110
28	X-RAY DIFFRACTION	28	B	111 - 122
29	X-RAY DIFFRACTION	29	B	123 - 129
30	X-RAY DIFFRACTION	30	B	130 - 144
31	X-RAY DIFFRACTION	31	B	145 - 150
32	X-RAY DIFFRACTION	32	B	151 - 162
33	X-RAY DIFFRACTION	33	B	163 - 173
34	X-RAY DIFFRACTION	34	B	174 - 207
35	X-RAY DIFFRACTION	35	B	208 - 269
36	X-RAY DIFFRACTION	36	B	270 - 278
37	X-RAY DIFFRACTION	37	B	279 - 284
38	X-RAY DIFFRACTION	38	B	285 - 289
39	X-RAY DIFFRACTION	39	B	290 - 302
40	X-RAY DIFFRACTION	40	B	303 - 313
41	X-RAY DIFFRACTION	41	C	26 - 35
42	X-RAY DIFFRACTION	42	C	36 - 41
43	X-RAY DIFFRACTION	43	C	42 - 50
44	X-RAY DIFFRACTION	44	C	51 - 66
45	X-RAY DIFFRACTION	45	C	67 - 71
46	X-RAY DIFFRACTION	46	C	72 - 99
47	X-RAY DIFFRACTION	47	C	100 - 109
48	X-RAY DIFFRACTION	48	C	110 - 126
49	X-RAY DIFFRACTION	49	C	127 - 144
50	X-RAY DIFFRACTION	50	C	145 - 160
51	X-RAY DIFFRACTION	51	C	161 - 174
52	X-RAY DIFFRACTION	52	C	175 - 193
53	X-RAY DIFFRACTION	53	C	194 - 207
54	X-RAY DIFFRACTION	54	C	208 - 255
55	X-RAY DIFFRACTION	55	C	256 - 269
56	X-RAY DIFFRACTION	56	C	270 - 274
57	X-RAY DIFFRACTION	57	C	275 - 285
58	X-RAY DIFFRACTION	58	C	286 - 294
59	X-RAY DIFFRACTION	59	C	295 - 307
60	X-RAY DIFFRACTION	60	C	308 - 313
61	X-RAY DIFFRACTION	61	D	26 - 34
62	X-RAY DIFFRACTION	62	D	35 - 39
63	X-RAY DIFFRACTION	63	D	40 - 48
64	X-RAY DIFFRACTION	64	D	49 - 63
65	X-RAY DIFFRACTION	65	D	64 - 70
66	X-RAY DIFFRACTION	66	D	71 - 99
67	X-RAY DIFFRACTION	67	D	100 - 122
68	X-RAY DIFFRACTION	68	D	123 - 131
69	X-RAY DIFFRACTION	69	D	132 - 146
70	X-RAY DIFFRACTION	70	D	147 - 153
71	X-RAY DIFFRACTION	71	D	154 - 163
72	X-RAY DIFFRACTION	72	D	164 - 173
73	X-RAY DIFFRACTION	73	D	174 - 207
74	X-RAY DIFFRACTION	74	D	208 - 238
75	X-RAY DIFFRACTION	75	D	239 - 265
76	X-RAY DIFFRACTION	76	D	266 - 279
77	X-RAY DIFFRACTION	77	D	280 - 285
78	X-RAY DIFFRACTION	78	D	286 - 294
79	X-RAY DIFFRACTION	79	D	295 - 306
80	X-RAY DIFFRACTION	80	D	307 - 313
81	X-RAY DIFFRACTION	81	E	26 - 37
82	X-RAY DIFFRACTION	82	E	38 - 43
83	X-RAY DIFFRACTION	83	E	44 - 61
84	X-RAY DIFFRACTION	84	E	62 - 70
85	X-RAY DIFFRACTION	85	E	71 - 90
86	X-RAY DIFFRACTION	86	E	91 - 98
87	X-RAY DIFFRACTION	87	E	99 - 114
88	X-RAY DIFFRACTION	88	E	115 - 127
89	X-RAY DIFFRACTION	89	E	128 - 140
90	X-RAY DIFFRACTION	90	E	141 - 162
91	X-RAY DIFFRACTION	91	E	163 - 174
92	X-RAY DIFFRACTION	92	E	175 - 199
93	X-RAY DIFFRACTION	93	E	200 - 231
94	X-RAY DIFFRACTION	94	E	232 - 264
95	X-RAY DIFFRACTION	95	E	265 - 275
96	X-RAY DIFFRACTION	96	E	276 - 280
97	X-RAY DIFFRACTION	97	E	281 - 288
98	X-RAY DIFFRACTION	98	E	289 - 296
99	X-RAY DIFFRACTION	99	E	297 - 304
100	X-RAY DIFFRACTION	100	E	305 - 313
101	X-RAY DIFFRACTION	101	F	26 - 35
102	X-RAY DIFFRACTION	102	F	36 - 41
103	X-RAY DIFFRACTION	103	F	42 - 50
104	X-RAY DIFFRACTION	104	F	51 - 65
105	X-RAY DIFFRACTION	105	F	66 - 82
106	X-RAY DIFFRACTION	106	F	83 - 98
107	X-RAY DIFFRACTION	107	F	99 - 109
108	X-RAY DIFFRACTION	108	F	110 - 125
109	X-RAY DIFFRACTION	109	F	126 - 135
110	X-RAY DIFFRACTION	110	F	136 - 154
111	X-RAY DIFFRACTION	111	F	155 - 162
112	X-RAY DIFFRACTION	112	F	163 - 174
113	X-RAY DIFFRACTION	113	F	175 - 194
114	X-RAY DIFFRACTION	114	F	195 - 211
115	X-RAY DIFFRACTION	115	F	212 - 265
116	X-RAY DIFFRACTION	116	F	266 - 272
117	X-RAY DIFFRACTION	117	F	273 - 285
118	X-RAY DIFFRACTION	118	F	286 - 294
119	X-RAY DIFFRACTION	119	F	295 - 307
120	X-RAY DIFFRACTION	120	F	308 - 313
121	X-RAY DIFFRACTION	121	G	26 - 36
122	X-RAY DIFFRACTION	122	G	37 - 44
123	X-RAY DIFFRACTION	123	G	45 - 60
124	X-RAY DIFFRACTION	124	G	61 - 65
125	X-RAY DIFFRACTION	125	G	66 - 81
126	X-RAY DIFFRACTION	126	G	82 - 98
127	X-RAY DIFFRACTION	127	G	99 - 114
128	X-RAY DIFFRACTION	128	G	115 - 124
129	X-RAY DIFFRACTION	129	G	125 - 130
130	X-RAY DIFFRACTION	130	G	131 - 144
131	X-RAY DIFFRACTION	131	G	145 - 160
132	X-RAY DIFFRACTION	132	G	161 - 174
133	X-RAY DIFFRACTION	133	G	175 - 198
134	X-RAY DIFFRACTION	134	G	199 - 256
135	X-RAY DIFFRACTION	135	G	257 - 268
136	X-RAY DIFFRACTION	136	G	269 - 279
137	X-RAY DIFFRACTION	137	G	280 - 286
138	X-RAY DIFFRACTION	138	G	287 - 299
139	X-RAY DIFFRACTION	139	G	300 - 307
140	X-RAY DIFFRACTION	140	G	308 - 313
141	X-RAY DIFFRACTION	141	H	26 - 32
142	X-RAY DIFFRACTION	142	H	33 - 40
143	X-RAY DIFFRACTION	143	H	41 - 50
144	X-RAY DIFFRACTION	144	H	51 - 61
145	X-RAY DIFFRACTION	145	H	62 - 68
146	X-RAY DIFFRACTION	146	H	69 - 85
147	X-RAY DIFFRACTION	147	H	86 - 98
148	X-RAY DIFFRACTION	148	H	99 - 124
149	X-RAY DIFFRACTION	149	H	125 - 129
150	X-RAY DIFFRACTION	150	H	130 - 162
151	X-RAY DIFFRACTION	151	H	163 - 174
152	X-RAY DIFFRACTION	152	H	175 - 199
153	X-RAY DIFFRACTION	153	H	200 - 220
154	X-RAY DIFFRACTION	154	H	221 - 244
155	X-RAY DIFFRACTION	155	H	245 - 277
156	X-RAY DIFFRACTION	156	H	278 - 284
157	X-RAY DIFFRACTION	157	H	285 - 289
158	X-RAY DIFFRACTION	158	H	290 - 296
159	X-RAY DIFFRACTION	159	H	297 - 305
160	X-RAY DIFFRACTION	160	H	306 - 313