+Open data
-Basic information
Entry | Database: PDB / ID: 5x5d | ||||||
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Title | Human thymidylate synthase bound with dUMP | ||||||
Components | Thymidylate synthase | ||||||
Keywords | TRANSFERASE / methyltransferase | ||||||
Function / homology | Function and homology information uracil metabolic process / response to organophosphorus / intestinal epithelial cell maturation / response to folic acid / Interconversion of nucleotide di- and triphosphates / thymidylate synthase / response to vitamin A / sequence-specific mRNA binding / cartilage development / tetrahydrofolate interconversion ...uracil metabolic process / response to organophosphorus / intestinal epithelial cell maturation / response to folic acid / Interconversion of nucleotide di- and triphosphates / thymidylate synthase / response to vitamin A / sequence-specific mRNA binding / cartilage development / tetrahydrofolate interconversion / thymidylate synthase activity / folic acid binding / dTMP biosynthetic process / dTTP biosynthetic process / DNA biosynthetic process / G1/S-Specific Transcription / developmental growth / response to glucocorticoid / mRNA regulatory element binding translation repressor activity / response to cytokine / response to progesterone / liver regeneration / response to toxic substance / circadian rhythm / methylation / response to ethanol / mitochondrial inner membrane / negative regulation of translation / mitochondrial matrix / response to xenobiotic stimulus / protein homodimerization activity / mitochondrion / nucleus / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å | ||||||
Authors | Chen, D. / Jansson, A. / Larsson, A. / Nordlund, P. | ||||||
Funding support | Singapore, 1items
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Citation | Journal: J. Biol. Chem. / Year: 2017 Title: Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states Authors: Chen, D. / Jansson, A. / Sim, D. / Larsson, A. / Nordlund, P. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 5x5d.cif.gz | 386.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb5x5d.ent.gz | 312.4 KB | Display | PDB format |
PDBx/mmJSON format | 5x5d.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/x5/5x5d ftp://data.pdbj.org/pub/pdb/validation_reports/x5/5x5d | HTTPS FTP |
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-Related structure data
Related structure data | 5x4wC 5x4xC 5x4yC 5x5aC 5x5qC 5x66C 5x67C 5x69C 1i00S C: citing same article (ref.) S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Beg auth comp-ID: PRO / Beg label comp-ID: PRO / Refine code: _
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