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基本情報
登録情報 | データベース: PDB / ID: 6kyh | ||||||
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タイトル | Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas | ||||||
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![]() | STRUCTURAL PROTEIN/SIGNALING PROTEIN / Shank3 / GTPase / synaptic scaffold protein / STRUCTURAL PROTEIN-SIGNALING PROTEIN complex | ||||||
機能・相同性 | ![]() Activation of RAS in B cells / Estrogen-stimulated signaling through PRKCZ / SHC1 events in ERBB4 signaling / GRB2 events in ERBB2 signaling / EGFR Transactivation by Gastrin / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / SHC-mediated cascade:FGFR2 / : ...Activation of RAS in B cells / Estrogen-stimulated signaling through PRKCZ / SHC1 events in ERBB4 signaling / GRB2 events in ERBB2 signaling / EGFR Transactivation by Gastrin / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / SHC-mediated cascade:FGFR2 / : / : / VEGFR2 mediated cell proliferation / FRS-mediated FGFR3 signaling / FRS-mediated FGFR4 signaling / MET activates RAS signaling / response to interleukin-17 / FRS-mediated FGFR1 signaling / FRS-mediated FGFR2 signaling / Tie2 Signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / FLT3 Signaling / regulation of cell cycle => GO:0051726 / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / Neurexins and neuroligins / regulation of AMPA glutamate receptor clustering / NCAM signaling for neurite out-growth / guanylate kinase-associated protein clustering / striatal medium spiny neuron differentiation / Downstream signal transduction / synaptic receptor adaptor activity / Negative regulation of MAPK pathway / EPHB-mediated forward signaling / postsynaptic density assembly / FCERI mediated MAPK activation / Signaling by SCF-KIT / RAF activation / embryonic epithelial tube formation / Regulation of RAS by GAPs / RAS processing / MAP2K and MAPK activation / positive regulation of synapse structural plasticity / : / RAF/MAP kinase cascade / negative regulation of actin filament bundle assembly / negative regulation of cell volume / structural constituent of postsynaptic density / response to isolation stress / positive regulation of glutamate receptor signaling pathway / regulation of grooming behavior / positive regulation of long-term neuronal synaptic plasticity / p38MAPK events / NMDA glutamate receptor clustering / vocalization behavior / CD209 (DC-SIGN) signaling / RET signaling / regulation of behavioral fear response / neuron spine / regulation of dendritic spine morphogenesis / AMPA glutamate receptor clustering / dendritic spine morphogenesis / neural precursor cell proliferation / brain morphogenesis / positive regulation of Ras protein signal transduction / locomotion / positive regulation of ruffle assembly / regulation of long-term synaptic potentiation / long-term synaptic depression / negative regulation of GTPase activity / DAP12 signaling / exploration behavior / ciliary membrane / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / positive regulation of miRNA metabolic process / regulation of postsynapse organization / T-helper 1 type immune response / regulation of long-term synaptic depression / small GTPase-mediated signal transduction / positive regulation of wound healing / positive regulation of dendritic spine development / defense response to protozoan / locomotory exploration behavior / associative learning / positive regulation of excitatory postsynaptic potential / social behavior / neuromuscular process controlling balance / excitatory synapse / positive regulation of protein targeting to membrane / postsynaptic density, intracellular component / glial cell proliferation / : / synapse assembly / ionotropic glutamate receptor binding / intrinsic apoptotic signaling pathway / positive regulation of synaptic transmission, glutamatergic / small monomeric GTPase / G protein activity / positive regulation of epithelial cell proliferation / positive regulation of GTPase activity / liver development 類似検索 - 分子機能 | ||||||
生物種 | ![]() ![]() | ||||||
手法 | ![]() ![]() ![]() | ||||||
![]() | Cai, Q. / Zhang, M. | ||||||
資金援助 | ![]()
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![]() | ![]() タイトル: Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms. 著者: Cai, Q. / Hosokawa, T. / Zeng, M. / Hayashi, Y. / Zhang, M. | ||||||
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非結晶学的対称性 (NCS) | NCSドメイン:
NCSドメイン領域: Component-ID: _ / Refine code: _
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