Entry Database : PDB / ID : 6amb Structure visualization Downloads & linksTitle Crystal Structure of the Afadin RA1 domain in complex with HRAS Components Details Keywords SIGNALING PROTEIN / GTPase / adhesion / RA domain / RBD domainFunction / homology Function and homology informationFunction Domain/homology Component
regulation of oligodendrocyte progenitor proliferation / radial glial cell differentiation / adherens junction maintenance / establishment of protein localization to plasma membrane / regulation of postsynapse assembly / protein localization to cell junction / pore complex assembly / Adherens junctions interactions / dendrite arborization / LIM domain binding ... regulation of oligodendrocyte progenitor proliferation / radial glial cell differentiation / adherens junction maintenance / establishment of protein localization to plasma membrane / regulation of postsynapse assembly / protein localization to cell junction / pore complex assembly / Adherens junctions interactions / dendrite arborization / LIM domain binding / telencephalon development / neuroepithelial cell differentiation / cell-cell adhesion mediated by cadherin / positive regulation of dendritic spine morphogenesis / positive regulation of dendrite extension / brain morphogenesis / GTPase complex / oncogene-induced cell senescence / positive regulation of mini excitatory postsynaptic potential / positive regulation of ruffle assembly / positive regulation of dendrite morphogenesis / negative regulation of GTPase activity / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / apical junction complex / positive regulation of miRNA metabolic process / T-helper 1 type immune response / positive regulation of wound healing / pore complex / defense response to protozoan / Signaling by RAS GAP mutants / Signaling by RAS GTPase mutants / Activation of RAS in B cells / RAS signaling downstream of NF1 loss-of-function variants / SOS-mediated signalling / Activated NTRK3 signals through RAS / Activated NTRK2 signals through RAS / homeostasis of number of cells / SHC1 events in ERBB4 signaling / positive regulation of protein targeting to membrane / Signalling to RAS / SHC-related events triggered by IGF1R / Activated NTRK2 signals through FRS2 and FRS3 / Estrogen-stimulated signaling through PRKCZ / adipose tissue development / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / : / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / Schwann cell development / SHC-mediated cascade:FGFR2 / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / SHC-mediated cascade:FGFR4 / Signaling by FGFR4 in disease / Erythropoietin activates RAS / SHC-mediated cascade:FGFR1 / protein-membrane adaptor activity / FRS-mediated FGFR3 signaling / presynaptic active zone membrane / Signaling by FLT3 ITD and TKD mutants / FRS-mediated FGFR2 signaling / Signaling by FGFR3 in disease / FRS-mediated FGFR4 signaling / p38MAPK events / Tie2 Signaling / FRS-mediated FGFR1 signaling / cell adhesion molecule binding / Signaling by FGFR2 in disease / somatodendritic compartment / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / EPHB-mediated forward signaling / EGFR Transactivation by Gastrin / Signaling by FLT3 fusion proteins / FLT3 Signaling / Ras activation upon Ca2+ influx through NMDA receptor / myelination / Signaling by FGFR1 in disease / GRB2 events in ERBB2 signaling / CD209 (DC-SIGN) signaling / NCAM signaling for neurite out-growth / SHC1 events in ERBB2 signaling / hippocampal mossy fiber to CA3 synapse / Downstream signal transduction / Constitutive Signaling by Overexpressed ERBB2 / Insulin receptor signalling cascade / intrinsic apoptotic signaling pathway / small monomeric GTPase / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / G protein activity / positive regulation of epithelial cell proliferation / positive regulation of GTPase activity / VEGFR2 mediated cell proliferation / regulation of actin cytoskeleton organization / FCERI mediated MAPK activation / adherens junction / animal organ morphogenesis / positive regulation of JNK cascade / Signaling by ERBB2 TMD/JMD mutants / RAF activation Similarity search - Function : / Afadin, cargo binding domain / Ras association (RalGDS/AF-6) domain / Dilute domain / DIL domain / Dilute domain profile. / DIL / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain ... : / Afadin, cargo binding domain / Ras association (RalGDS/AF-6) domain / Dilute domain / DIL domain / Dilute domain profile. / DIL / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain / Forkhead associated domain / FHA domain / Forkhead-associated (FHA) domain / SMAD/FHA domain superfamily / Small GTPase, Ras-type / small GTPase Ras family profile. / PDZ domain / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Rab subfamily of small GTPases / Small GTP-binding protein domain / Ubiquitin-like domain superfamily / P-loop containing nucleotide triphosphate hydrolases / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.5 Å DetailsAuthors Smith, M.J. / Ishiyama, N. / Ikura, M. CitationJournal : Nat Commun / Year : 2017Title : Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.Authors: Smith, M.J. / Ottoni, E. / Ishiyama, N. / Goudreault, M. / Haman, A. / Meyer, C. / Tucholska, M. / Gasmi-Seabrook, G. / Menezes, S. / Laister, R.C. / Minden, M.D. / Marschalek, R. / Gingras, ... Authors : Smith, M.J. / Ottoni, E. / Ishiyama, N. / Goudreault, M. / Haman, A. / Meyer, C. / Tucholska, M. / Gasmi-Seabrook, G. / Menezes, S. / Laister, R.C. / Minden, M.D. / Marschalek, R. / Gingras, A.C. / Hoang, T. / Ikura, M. History Deposition Aug 9, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 1, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Nov 8, 2017 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name Revision 1.2 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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