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Yorodumi- PDB-6kyh: Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas -
+Open data
-Basic information
Entry | Database: PDB / ID: 6kyh | ||||||
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Title | Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas | ||||||
Components |
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Keywords | STRUCTURAL PROTEIN/SIGNALING PROTEIN / Shank3 / GTPase / synaptic scaffold protein / STRUCTURAL PROTEIN-SIGNALING PROTEIN complex | ||||||
Function / homology | Function and homology information Activation of RAS in B cells / Estrogen-stimulated signaling through PRKCZ / SHC1 events in ERBB4 signaling / GRB2 events in ERBB2 signaling / EGFR Transactivation by Gastrin / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / SHC-mediated cascade:FGFR2 / : ...Activation of RAS in B cells / Estrogen-stimulated signaling through PRKCZ / SHC1 events in ERBB4 signaling / GRB2 events in ERBB2 signaling / EGFR Transactivation by Gastrin / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / SHC-mediated cascade:FGFR2 / : / : / VEGFR2 mediated cell proliferation / FRS-mediated FGFR3 signaling / FRS-mediated FGFR4 signaling / MET activates RAS signaling / response to interleukin-17 / FRS-mediated FGFR1 signaling / FRS-mediated FGFR2 signaling / Tie2 Signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / FLT3 Signaling / regulation of cell cycle => GO:0051726 / Neurexins and neuroligins / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / regulation of AMPA glutamate receptor clustering / NCAM signaling for neurite out-growth / guanylate kinase-associated protein clustering / striatal medium spiny neuron differentiation / synaptic receptor adaptor activity / Downstream signal transduction / positive regulation of glutamate receptor signaling pathway / Negative regulation of MAPK pathway / EPHB-mediated forward signaling / postsynaptic density assembly / FCERI mediated MAPK activation / Signaling by SCF-KIT / RAF activation / Regulation of RAS by GAPs / embryonic epithelial tube formation / RAS processing / NMDA glutamate receptor clustering / MAP2K and MAPK activation / positive regulation of synapse structural plasticity / negative regulation of actin filament bundle assembly / RAF/MAP kinase cascade / : / vocal learning / negative regulation of cell volume / regulation of behavioral fear response / positive regulation of long-term neuronal synaptic plasticity / regulation of grooming behavior / structural constituent of postsynaptic density / response to isolation stress / AMPA glutamate receptor clustering / p38MAPK events / vocalization behavior / CD209 (DC-SIGN) signaling / RET signaling / neuron spine / regulation of dendritic spine morphogenesis / neural precursor cell proliferation / locomotion / dendritic spine morphogenesis / exploration behavior / brain morphogenesis / positive regulation of Ras protein signal transduction / regulation of long-term synaptic potentiation / positive regulation of ruffle assembly / positive regulation of AMPA receptor activity / long-term synaptic depression / regulation of postsynapse organization / positive regulation of dendritic spine development / negative regulation of GTPase activity / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / DAP12 signaling / ciliary membrane / positive regulation of miRNA metabolic process / regulation of long-term synaptic depression / adult behavior / T-helper 1 type immune response / small GTPase-mediated signal transduction / locomotory exploration behavior / positive regulation of wound healing / defense response to protozoan / postsynaptic density, intracellular component / social behavior / positive regulation of excitatory postsynaptic potential / associative learning / neuromuscular process controlling balance / excitatory synapse / positive regulation of protein targeting to membrane / positive regulation of DNA replication / glial cell proliferation / positive regulation of phospholipase C activity / synapse assembly / ionotropic glutamate receptor binding / intrinsic apoptotic signaling pathway / positive regulation of synaptic transmission, glutamatergic / small monomeric GTPase Similarity search - Function | ||||||
Biological species | Mus musculus (house mouse) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.3 Å | ||||||
Authors | Cai, Q. / Zhang, M. | ||||||
Funding support | Hong Kong, 1items
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Citation | Journal: Structure / Year: 2020 Title: Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms. Authors: Cai, Q. / Hosokawa, T. / Zeng, M. / Hayashi, Y. / Zhang, M. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6kyh.cif.gz | 410.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6kyh.ent.gz | 333.5 KB | Display | PDB format |
PDBx/mmJSON format | 6kyh.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ky/6kyh ftp://data.pdbj.org/pub/pdb/validation_reports/ky/6kyh | HTTPS FTP |
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-Related structure data
Related structure data | 6kykC 5g4xS 6ambS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: 0 / Refine code: 0
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