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- PDB-6kyh: Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas -
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Open data
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Basic information
Entry | Database: PDB / ID: 6kyh | ||||||
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Title | Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas | ||||||
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![]() | STRUCTURAL PROTEIN/SIGNALING PROTEIN / Shank3 / GTPase / synaptic scaffold protein / STRUCTURAL PROTEIN-SIGNALING PROTEIN complex | ||||||
Function / homology | ![]() Activation of RAS in B cells / Estrogen-stimulated signaling through PRKCZ / SHC1 events in ERBB4 signaling / GRB2 events in ERBB2 signaling / EGFR Transactivation by Gastrin / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / SHC-mediated cascade:FGFR2 / : ...Activation of RAS in B cells / Estrogen-stimulated signaling through PRKCZ / SHC1 events in ERBB4 signaling / GRB2 events in ERBB2 signaling / EGFR Transactivation by Gastrin / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / SHC-mediated cascade:FGFR2 / : / : / VEGFR2 mediated cell proliferation / FRS-mediated FGFR3 signaling / FRS-mediated FGFR4 signaling / MET activates RAS signaling / response to interleukin-17 / FRS-mediated FGFR1 signaling / FRS-mediated FGFR2 signaling / Tie2 Signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / FLT3 Signaling / regulation of cell cycle => GO:0051726 / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / Neurexins and neuroligins / regulation of AMPA glutamate receptor clustering / NCAM signaling for neurite out-growth / guanylate kinase-associated protein clustering / striatal medium spiny neuron differentiation / Downstream signal transduction / synaptic receptor adaptor activity / Negative regulation of MAPK pathway / EPHB-mediated forward signaling / postsynaptic density assembly / FCERI mediated MAPK activation / Signaling by SCF-KIT / RAF activation / embryonic epithelial tube formation / Regulation of RAS by GAPs / RAS processing / MAP2K and MAPK activation / positive regulation of synapse structural plasticity / : / RAF/MAP kinase cascade / negative regulation of actin filament bundle assembly / negative regulation of cell volume / structural constituent of postsynaptic density / response to isolation stress / positive regulation of glutamate receptor signaling pathway / regulation of grooming behavior / positive regulation of long-term neuronal synaptic plasticity / p38MAPK events / NMDA glutamate receptor clustering / vocalization behavior / CD209 (DC-SIGN) signaling / RET signaling / regulation of behavioral fear response / neuron spine / regulation of dendritic spine morphogenesis / AMPA glutamate receptor clustering / dendritic spine morphogenesis / neural precursor cell proliferation / brain morphogenesis / positive regulation of Ras protein signal transduction / locomotion / positive regulation of ruffle assembly / regulation of long-term synaptic potentiation / long-term synaptic depression / negative regulation of GTPase activity / DAP12 signaling / exploration behavior / ciliary membrane / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / positive regulation of miRNA metabolic process / regulation of postsynapse organization / T-helper 1 type immune response / regulation of long-term synaptic depression / small GTPase-mediated signal transduction / positive regulation of wound healing / positive regulation of dendritic spine development / defense response to protozoan / locomotory exploration behavior / associative learning / positive regulation of excitatory postsynaptic potential / social behavior / neuromuscular process controlling balance / excitatory synapse / positive regulation of protein targeting to membrane / postsynaptic density, intracellular component / glial cell proliferation / : / synapse assembly / ionotropic glutamate receptor binding / intrinsic apoptotic signaling pathway / positive regulation of synaptic transmission, glutamatergic / small monomeric GTPase / G protein activity / positive regulation of epithelial cell proliferation / positive regulation of GTPase activity / liver development Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() ![]() | ||||||
![]() | Cai, Q. / Zhang, M. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms. Authors: Cai, Q. / Hosokawa, T. / Zeng, M. / Hayashi, Y. / Zhang, M. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 410.8 KB | Display | ![]() |
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PDB format | ![]() | 333.5 KB | Display | ![]() |
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-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 6kykC ![]() 5g4xS ![]() 6ambS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Refine code: _
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