Entry Database : PDB / ID : 6h06 Structure visualization Downloads & linksTitle FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5 ComponentsHUMAN FAB ANTIBODY FRAGMENT OF CBTAU-22.1 HUMAN FAB ANTIBODY FRAGMENT OF HCBTAU-22.1 Microtubule-associated protein tau DetailsKeywords IMMUNE SYSTEM / FAB / Tau peptide / complexFunction / homology Function and homology informationFunction Domain/homology Component
plus-end-directed organelle transport along microtubule / axonal transport / histone-dependent DNA binding / neurofibrillary tangle assembly / positive regulation of diacylglycerol kinase activity / negative regulation of establishment of protein localization to mitochondrion / neurofibrillary tangle / positive regulation of protein localization to synapse / microtubule lateral binding / tubulin complex ... plus-end-directed organelle transport along microtubule / axonal transport / histone-dependent DNA binding / neurofibrillary tangle assembly / positive regulation of diacylglycerol kinase activity / negative regulation of establishment of protein localization to mitochondrion / neurofibrillary tangle / positive regulation of protein localization to synapse / microtubule lateral binding / tubulin complex / phosphatidylinositol bisphosphate binding / main axon / regulation of long-term synaptic depression / negative regulation of kinase activity / negative regulation of tubulin deacetylation / generation of neurons / regulation of chromosome organization / positive regulation of protein localization / rRNA metabolic process / internal protein amino acid acetylation / regulation of mitochondrial fission / intracellular distribution of mitochondria / axonal transport of mitochondrion / axon development / central nervous system neuron development / regulation of microtubule polymerization / microtubule polymerization / minor groove of adenine-thymine-rich DNA binding / lipoprotein particle binding / dynactin binding / apolipoprotein binding / glial cell projection / negative regulation of mitochondrial membrane potential / protein polymerization / negative regulation of mitochondrial fission / axolemma / Caspase-mediated cleavage of cytoskeletal proteins / regulation of microtubule polymerization or depolymerization / positive regulation of axon extension / regulation of microtubule cytoskeleton organization / Activation of AMPK downstream of NMDARs / supramolecular fiber organization / regulation of cellular response to heat / stress granule assembly / cytoplasmic microtubule organization / regulation of calcium-mediated signaling / axon cytoplasm / positive regulation of microtubule polymerization / somatodendritic compartment / cellular response to brain-derived neurotrophic factor stimulus / synapse assembly / phosphatidylinositol binding / nuclear periphery / cellular response to nerve growth factor stimulus / positive regulation of superoxide anion generation / protein phosphatase 2A binding / regulation of autophagy / astrocyte activation / response to lead ion / synapse organization / microglial cell activation / Hsp90 protein binding / regulation of synaptic plasticity / PKR-mediated signaling / protein homooligomerization / memory / cytoplasmic ribonucleoprotein granule / microtubule cytoskeleton organization / cellular response to reactive oxygen species / SH3 domain binding / activation of cysteine-type endopeptidase activity involved in apoptotic process / microtubule cytoskeleton / neuron projection development / cell-cell signaling / protein-macromolecule adaptor activity / actin binding / single-stranded DNA binding / cellular response to heat / protein-folding chaperone binding / cell body / growth cone / microtubule binding / double-stranded DNA binding / microtubule / amyloid fibril formation / sequence-specific DNA binding / dendritic spine / learning or memory / nuclear speck / neuron projection / membrane raft / axon / negative regulation of gene expression / neuronal cell body / DNA damage response / dendrite / protein kinase binding / enzyme binding / mitochondrion / DNA binding Similarity search - Function : / Microtubule associated protein, tubulin-binding repeat / Microtubule-associated protein Tau / Tau and MAP protein, tubulin-binding repeat / Tau and MAP proteins tubulin-binding repeat signature. / Tau and MAP proteins tubulin-binding repeat profile. / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.63 Å DetailsAuthors Juraszek, J. / Steinbacher, S. CitationJournal : Acta Neuropathol Commun / Year : 2018Title : Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422containing epitope on pathological tau.Authors: van Ameijde, J. / Crespo, R. / Janson, R. / Juraszek, J. / Siregar, B. / Verveen, H. / Sprengers, I. / Nahar, T. / Hoozemans, J.J. / Steinbacher, S. / Willems, R. / Delbroek, L. / Borgers, M. ... Authors : van Ameijde, J. / Crespo, R. / Janson, R. / Juraszek, J. / Siregar, B. / Verveen, H. / Sprengers, I. / Nahar, T. / Hoozemans, J.J. / Steinbacher, S. / Willems, R. / Delbroek, L. / Borgers, M. / Dockx, K. / Van Kolen, K. / Mercken, M. / Pascual, G. / Koudstaal, W. / Apetri, A. History Deposition Jul 6, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jul 25, 2018 Provider : repository / Type : Initial releaseRevision 2.0 Mar 11, 2020 Group : Database references / Polymer sequence / Category : citation / entity_polyItem : _citation.country / _entity_poly.pdbx_seq_one_letter_code_can