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Structure paper

TitleEnhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422containing epitope on pathological tau.
Journal, issue, pagesActa Neuropathol Commun, Vol. 6, Page 59-59, Year 2018
Publish dateJul 6, 2018 (structure data deposition date)
Authorsvan Ameijde, J. / Crespo, R. / Janson, R. / Juraszek, J. / Siregar, B. / Verveen, H. / Sprengers, I. / Nahar, T. / Hoozemans, J.J. / Steinbacher, S. ...van Ameijde, J. / Crespo, R. / Janson, R. / Juraszek, J. / Siregar, B. / Verveen, H. / Sprengers, I. / Nahar, T. / Hoozemans, J.J. / Steinbacher, S. / Willems, R. / Delbroek, L. / Borgers, M. / Dockx, K. / Van Kolen, K. / Mercken, M. / Pascual, G. / Koudstaal, W. / Apetri, A.
External linksActa Neuropathol Commun / PubMed:30001207
MethodsX-ray diffraction
Resolution1.95 - 2.63 Å
Structure data

PDB-6h06:
FAB CBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-5
Method: X-RAY DIFFRACTION / Resolution: 2.63 Å

PDB-6h0e:
FAB dmCBTAU-22.1 IN COMPLEX WITH TAU PEPTIDE V1088-23
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / FAB / Tau peptide / complex

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