登録情報 | データベース: PDB / ID: 6fbb |
---|
タイトル | Crystal structure of 14-3-3 sigma in complex with wild-type Shroom3 |
---|
要素 | - 14-3-3 protein sigma
- Shroom3
|
---|
キーワード | PEPTIDE BINDING PROTEIN / Complex |
---|
機能・相同性 | 機能・相同性情報
cellular pigment accumulation / pattern specification process / apical protein localization / apical junction complex / cortical actin cytoskeleton / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / epithelial cell development ...cellular pigment accumulation / pattern specification process / apical protein localization / apical junction complex / cortical actin cytoskeleton / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / epithelial cell development / keratinization / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / establishment of skin barrier / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / RHO GTPases activate PKNs / protein sequestering activity / protein kinase A signaling / negative regulation of innate immune response / protein export from nucleus / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / release of cytochrome c from mitochondria / positive regulation of protein export from nucleus / stem cell proliferation / neural tube closure / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / actin filament organization / adherens junction / negative regulation of protein kinase activity / cell morphogenesis / intrinsic apoptotic signaling pathway in response to DNA damage / protein localization / actin filament binding / regulation of cell shape / positive regulation of cell growth / microtubule / cytoskeleton / regulation of cell cycle / cadherin binding / apical plasma membrane / protein kinase binding / negative regulation of transcription by RNA polymerase II / signal transduction / extracellular space / extracellular exosome / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Shroom3 / Apx/Shrm Domain 1 / Apx/Shroom domain ASD1 / ASD1 domain profile. / Apx/Shrm Domain 2 / Shroom family / Apx/Shroom domain ASD2 / ASD2 domain profile. / 14-3-3 domain / Delta-Endotoxin; domain 1 ...Shroom3 / Apx/Shrm Domain 1 / Apx/Shroom domain ASD1 / ASD1 domain profile. / Apx/Shrm Domain 2 / Shroom family / Apx/Shroom domain ASD2 / ASD2 domain profile. / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 解像度: 1.3 Å |
---|
データ登録者 | Leysen, S. / Meijer, F.A. / Milroy, L.G. / Ottmann, C. |
---|
引用 | ジャーナル: J. Am. Soc. Nephrol. / 年: 2018 タイトル: Characterization of Coding/Noncoding Variants forSHROOM3in Patients with CKD. 著者: Prokop, J.W. / Yeo, N.C. / Ottmann, C. / Chhetri, S.B. / Florus, K.L. / Ross, E.J. / Sosonkina, N. / Link, B.A. / Freedman, B.I. / Coppola, C.J. / McDermott-Roe, C. / Leysen, S. / Milroy, L.G. ...著者: Prokop, J.W. / Yeo, N.C. / Ottmann, C. / Chhetri, S.B. / Florus, K.L. / Ross, E.J. / Sosonkina, N. / Link, B.A. / Freedman, B.I. / Coppola, C.J. / McDermott-Roe, C. / Leysen, S. / Milroy, L.G. / Meijer, F.A. / Geurts, A.M. / Rauscher, F.J. / Ramaker, R. / Flister, M.J. / Jacob, H.J. / Mendenhall, E.M. / Lazar, J. |
---|
履歴 | 登録 | 2017年12月18日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2018年3月14日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2018年3月28日 | Group: Data collection / Database references / カテゴリ: citation / Item: _citation.title |
---|
改定 1.2 | 2018年5月9日 | Group: Data collection / Database references / Source and taxonomy カテゴリ: citation / entity_src_gen Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strain / _entity_src_gen.pdbx_host_org_variant |
---|
|
---|