Entry Database : PDB / ID : 6fcp Structure visualization Downloads & linksTitle Crystal structure of 14-3-3 sigma in complex with Shroom3 P1244L Components14-3-3 protein sigma Protein Shroom3 DetailsKeywords PEPTIDE BINDING PROTEIN / ComplexFunction / homology Function and homology informationFunction Domain/homology Component
cellular pigment accumulation / pattern specification process / apical protein localization / apical junction complex / cortical actin cytoskeleton / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / epithelial cell development ... cellular pigment accumulation / pattern specification process / apical protein localization / apical junction complex / cortical actin cytoskeleton / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / epithelial cell development / keratinization / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / establishment of skin barrier / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / RHO GTPases activate PKNs / protein kinase A signaling / protein sequestering activity / negative regulation of innate immune response / protein export from nucleus / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / positive regulation of protein export from nucleus / release of cytochrome c from mitochondria / stem cell proliferation / neural tube closure / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / actin filament organization / adherens junction / negative regulation of protein kinase activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / cell morphogenesis / intrinsic apoptotic signaling pathway in response to DNA damage / actin filament binding / regulation of cell shape / positive regulation of cell growth / microtubule / cytoskeleton / regulation of cell cycle / cadherin binding / apical plasma membrane / protein kinase binding / negative regulation of transcription by RNA polymerase II / signal transduction / extracellular space / extracellular exosome / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function Shroom3 / Apx/Shrm Domain 1 / Apx/Shroom domain ASD1 / ASD1 domain profile. / Apx/Shrm Domain 2 / Shroom family / Apx/Shroom domain ASD2 / ASD2 domain profile. / 14-3-3 domain / Delta-Endotoxin; domain 1 ... Shroom3 / Apx/Shrm Domain 1 / Apx/Shroom domain ASD1 / ASD1 domain profile. / Apx/Shrm Domain 2 / Shroom family / Apx/Shroom domain ASD2 / ASD2 domain profile. / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.45 Å DetailsAuthors Leysen, S. / Meijer, F.A. / Milroy, L.G. / Ottmann, C. CitationJournal : J. Am. Soc. Nephrol. / Year : 2018Title : Characterization of Coding/Noncoding Variants forSHROOM3in Patients with CKD.Authors: Prokop, J.W. / Yeo, N.C. / Ottmann, C. / Chhetri, S.B. / Florus, K.L. / Ross, E.J. / Sosonkina, N. / Link, B.A. / Freedman, B.I. / Coppola, C.J. / McDermott-Roe, C. / Leysen, S. / Milroy, L. ... Authors : Prokop, J.W. / Yeo, N.C. / Ottmann, C. / Chhetri, S.B. / Florus, K.L. / Ross, E.J. / Sosonkina, N. / Link, B.A. / Freedman, B.I. / Coppola, C.J. / McDermott-Roe, C. / Leysen, S. / Milroy, L.G. / Meijer, F.A. / Geurts, A.M. / Rauscher, F.J. / Ramaker, R. / Flister, M.J. / Jacob, H.J. / Mendenhall, E.M. / Lazar, J. History Deposition Dec 20, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 14, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Jul 11, 2018 Group : Data collection / Database references / Category : citationItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title Revision 2.0 Jan 17, 2024 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations / Refinement description Category : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_conn_type Item : _atom_site.occupancy / _database_2.pdbx_DOI ... _atom_site.occupancy / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_conn_type.id
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