Entry Database : PDB / ID : 6egs Structure visualization Downloads & linksTitle Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc ComponentsPolypeptide N-acetylgalactosaminyltransferase 2 Details Keywords TRANSFERASE / F104S mutant / GalNAc-T2 / HDL / Glycosyltransferase / flexible loop / Inactive/Active statesFunction / homology Function and homology informationFunction Domain/homology Component
protein O-linked glycosylation via threonine / protein O-linked glycosylation via serine / polypeptide N-acetylgalactosaminyltransferase / polypeptide N-acetylgalactosaminyltransferase activity / O-glycan processing / O-linked glycosylation of mucins / Golgi stack / COPI-independent Golgi-to-ER retrograde traffic / protein O-linked glycosylation / Golgi cisterna membrane ... protein O-linked glycosylation via threonine / protein O-linked glycosylation via serine / polypeptide N-acetylgalactosaminyltransferase / polypeptide N-acetylgalactosaminyltransferase activity / O-glycan processing / O-linked glycosylation of mucins / Golgi stack / COPI-independent Golgi-to-ER retrograde traffic / protein O-linked glycosylation / Golgi cisterna membrane / protein maturation / manganese ion binding / carbohydrate binding / Golgi membrane / endoplasmic reticulum membrane / perinuclear region of cytoplasm / Golgi apparatus / extracellular region / membrane Similarity search - Function N-acetylgalactosaminyltransferase / Glycosyltransferase 2-like / Glycosyl transferase family 2 / Ricin-type beta-trefoil lectin domain / Ricin-type beta-trefoil / Lectin domain of ricin B chain profile. / Ricin B, lectin domain / Ricin B-like lectins / Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A / Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A ... N-acetylgalactosaminyltransferase / Glycosyltransferase 2-like / Glycosyl transferase family 2 / Ricin-type beta-trefoil lectin domain / Ricin-type beta-trefoil / Lectin domain of ricin B chain profile. / Ricin B, lectin domain / Ricin B-like lectins / Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A / Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A / Nucleotide-diphospho-sugar transferases / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.7 Å DetailsAuthors de las Rivas, M. / Coelho, H. / Diniz, A. / Lira-Navarrete, E. / Jimenez-Barbero, J. / Schjoldager, K.T. / Bennett, E.P. / Vakhrushev, S.Y. / Clausen, H. / Corzana, F. ...de las Rivas, M. / Coelho, H. / Diniz, A. / Lira-Navarrete, E. / Jimenez-Barbero, J. / Schjoldager, K.T. / Bennett, E.P. / Vakhrushev, S.Y. / Clausen, H. / Corzana, F. / Marcelo, F. / Hurtado-Guerrero, R. CitationJournal : Chemistry / Year : 2018Title : Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.Authors: de Las Rivas, M. / Coelho, H. / Diniz, A. / Lira-Navarrete, E. / Companon, I. / Jimenez-Barbero, J. / Schjoldager, K.T. / Bennett, E.P. / Vakhrushev, S.Y. / Clausen, H. / Corzana, F. / ... Authors : de Las Rivas, M. / Coelho, H. / Diniz, A. / Lira-Navarrete, E. / Companon, I. / Jimenez-Barbero, J. / Schjoldager, K.T. / Bennett, E.P. / Vakhrushev, S.Y. / Clausen, H. / Corzana, F. / Marcelo, F. / Hurtado-Guerrero, R. History Deposition Sep 12, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 11, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Jun 27, 2018 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name Revision 1.2 Jan 17, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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