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TitleStructural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.
Journal, issue, pagesChemistry, Vol. 24, Page 8382-8392, Year 2018
Publish dateSep 12, 2017 (structure data deposition date)
Authorsde Las Rivas, M. / Coelho, H. / Diniz, A. / Lira-Navarrete, E. / Companon, I. / Jimenez-Barbero, J. / Schjoldager, K.T. / Bennett, E.P. / Vakhrushev, S.Y. / Clausen, H. ...de Las Rivas, M. / Coelho, H. / Diniz, A. / Lira-Navarrete, E. / Companon, I. / Jimenez-Barbero, J. / Schjoldager, K.T. / Bennett, E.P. / Vakhrushev, S.Y. / Clausen, H. / Corzana, F. / Marcelo, F. / Hurtado-Guerrero, R.
External linksChemistry / PubMed:29601100
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-6egs:
Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-UD2:
URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / F104S mutant / GalNAc-T2 / HDL / Glycosyltransferase / flexible loop / Inactive/Active states

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