- PDB-6d35: Crystal structure of Xenopus Smoothened in complex with cholesterol -
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基本情報
登録情報
データベース: PDB / ID: 6d35
タイトル
Crystal structure of Xenopus Smoothened in complex with cholesterol
要素
Smoothened,Soluble cytochrome b562,Smoothened
キーワード
MEMBRANE PROTEIN / GPCR / Hedgehog signaling / Class Frizzled / Sterol
機能・相同性
機能・相同性情報
tissue development / patched binding / pattern specification process / commissural neuron axon guidance / smoothened signaling pathway / central nervous system development / G protein-coupled receptor activity / electron transport chain / cilium / membrane => GO:0016020 ...tissue development / patched binding / pattern specification process / commissural neuron axon guidance / smoothened signaling pathway / central nervous system development / G protein-coupled receptor activity / electron transport chain / cilium / membrane => GO:0016020 / periplasmic space / electron transfer activity / iron ion binding / dendrite / heme binding / metal ion binding / plasma membrane 類似検索 - 分子機能
Smoothened / Smoothened, transmembrane domain / Smoothened, cysteine-rich domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / Frizzled domain / Frizzled cysteine-rich domain superfamily ...Smoothened / Smoothened, transmembrane domain / Smoothened, cysteine-rich domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain / Frizzled (fz) domain profile. / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 類似検索 - ドメイン・相同性
CHOLESTEROL / Uncharacterized protein / Soluble cytochrome b562 / Protein smoothened 類似検索 - 構成要素
温度: 293 K / 手法: 脂質キュービック相法 詳細: Reconstituted in 10:1 monoolein:cholesterol mix. Precipitant solution: 35-45% PEG 300, 300-500 mM LiSO4, 0.1 M MES pH 6-6.5