Entry Database : PDB / ID : 6cwg Structure visualization Downloads & linksTitle Ricin catalytic subunit bound go A9 VHH antibody Components Details Keywords IMMUNE SYSTEM / Ricin catalytic subunit / VHH antibodyFunction / homology Function and homology informationFunction Domain/homology Component
rRNA N-glycosylase / rRNA N-glycosylase activity / AMP binding / defense response / carbohydrate binding / toxin activity / killing of cells of another organism / negative regulation of translation Similarity search - Function Ricin (A Subunit), domain 2 / Ricin (A Subunit), domain 2 / Ricin (A subunit); domain 1 / Ricin (A subunit), domain 1 / Ribosome-inactivating protein conserved site / Shiga/ricin ribosomal inactivating toxins active site signature. / Ricin-type beta-trefoil lectin domain / Ribosome-inactivating protein type 1/2 / Ribosome-inactivating protein / Ribosome-inactivating protein, subdomain 1 ... Ricin (A Subunit), domain 2 / Ricin (A Subunit), domain 2 / Ricin (A subunit); domain 1 / Ricin (A subunit), domain 1 / Ribosome-inactivating protein conserved site / Shiga/ricin ribosomal inactivating toxins active site signature. / Ricin-type beta-trefoil lectin domain / Ribosome-inactivating protein type 1/2 / Ribosome-inactivating protein / Ribosome-inactivating protein, subdomain 1 / Ribosome-inactivating protein, subdomain 2 / Ribosome-inactivating protein superfamily / Ribosome inactivating protein / Ricin-type beta-trefoil / Lectin domain of ricin B chain profile. / Ricin B, lectin domain / Ricin B-like lectins / Few Secondary Structures / Irregular / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Ricinus communis (castor bean)Vicugna pacos (alpaca)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.6 Å DetailsAuthors Rudolph, M.J. / Mantis, N. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) HHSN272201400021C United States
CitationJournal : Protein Eng. Des. Sel. / Year : 2018Title : Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.Authors : Rudolph, M.J. / Vance, D.J. / Kelow, S. / Angalakurthi, S.K. / Nguyen, S. / Davis, S.A. / Rong, Y. / Middaugh, C.R. / Weis, D.D. / Dunbrack Jr., R. / Karanicolas, J. / Mantis, N.J. History Deposition Mar 30, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 16, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Dec 18, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization
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