Entry Database : PDB / ID : 6c7o Structure visualization Downloads & linksTitle Crystal structure of D477G ACO/RPE65 chimera, trigonal crystal form ComponentsApocarotenoid-15,15'-oxygenase Details Keywords OXIDOREDUCTASE / non-heme iron / chimera / 7-bladed propeller / dominant mutationFunction / homology Function and homology informationFunction Domain/homology Component
all-trans-8'-apo-beta-carotenal 15,15'-oxygenase / all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity / carotenoid dioxygenase activity / 9-cis-epoxycarotenoid dioxygenase activity / carotene catabolic process / metal ion binding Similarity search - FunctionBiological species Synechocystis sp. (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.15 Å DetailsAuthors Kiser, P.D. / Shi, W. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Eye Institute (NIH/NEI) EY009339 United States Department of Veterans Affairs IK2BX002683 United States
CitationJournal : Hum.Mol.Genet. / Year : 2018Title : Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.Authors : Choi, E.H. / Suh, S. / Sander, C.L. / Hernandez, C.J.O. / Bulman, E.R. / Khadka, N. / Dong, Z. / Shi, W. / Palczewski, K. / Kiser, P.D. History Deposition Jan 23, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 25, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Feb 20, 2019 Group : Author supporting evidence / Data collection / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.2 May 8, 2019 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name Revision 1.3 Dec 11, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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