Entry | Database: PDB / ID: 5vi4 |
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Title | IL-33/ST2/IL-1RAcP ternary complex structure |
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Components | - Interleukin-1 receptor accessory protein
- Interleukin-1 receptor-like 1
- Interleukin-33
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Keywords | SIGNALING PROTEIN / cytokine / cytokine receptor / signaling |
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Function / homology | Function and homology information
interleukin-33 binding / Interleukin-36 pathway / Interleukin-33 signaling / interleukin-33 receptor binding / negative regulation of macrophage proliferation / positive regulation of CD86 production / positive regulation of CD80 production / positive regulation of cellular defense response / interleukin-33 receptor activity / positive regulation of MHC class I biosynthetic process ...interleukin-33 binding / Interleukin-36 pathway / Interleukin-33 signaling / interleukin-33 receptor binding / negative regulation of macrophage proliferation / positive regulation of CD86 production / positive regulation of CD80 production / positive regulation of cellular defense response / interleukin-33 receptor activity / positive regulation of MHC class I biosynthetic process / negative regulation of T-helper 1 type immune response / interleukin-1 receptor activity / Receptor-type tyrosine-protein phosphatases / negative regulation of immunoglobulin production / trans-synaptic signaling by trans-synaptic complex / microglial cell activation involved in immune response / NADP+ nucleosidase activity / regulation of postsynaptic density assembly / synaptic membrane adhesion / Interleukin-1 signaling / negative regulation of leukocyte migration / PIP3 activates AKT signaling / regulation of sensory perception of pain / microglial cell proliferation / interleukin-33-mediated signaling pathway / positive regulation of type 2 immune response / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / positive regulation of interleukin-13 production / positive regulation of interleukin-5 production / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase / Ub-specific processing proteases / macrophage activation involved in immune response / NAD+ nucleotidase, cyclic ADP-ribose generating / positive regulation of MHC class II biosynthetic process / interleukin-1 receptor binding / positive regulation of macrophage activation / positive regulation of synapse assembly / interleukin-1-mediated signaling pathway / positive regulation of immunoglobulin production / positive regulation of oligodendrocyte differentiation / positive regulation of interleukin-4 production / positive regulation of nitric-oxide synthase biosynthetic process / negative regulation of type II interferon production / regulation of presynapse assembly / coreceptor activity / extrinsic apoptotic signaling pathway / positive regulation of chemokine production / transport vesicle / positive regulation of cytokine production / cytokine activity / cytokine-mediated signaling pathway / positive regulation of inflammatory response / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / chromosome / positive regulation of NF-kappaB transcription factor activity / defense response to virus / membrane => GO:0016020 / inflammatory response / negative regulation of cell population proliferation / external side of plasma membrane / intracellular membrane-bounded organelle / innate immune response / focal adhesion / glutamatergic synapse / synapse / positive regulation of gene expression / cell surface / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / extracellular space / extracellular region / nucleoplasm / nucleus / plasma membrane / cytoplasm / cytosolSimilarity search - Function Interleukin-33 / Interleukin 33 / Interleukin-1 receptor type I/II / IL-1Ra-like, immunoglobulin domain / Immunoglobulin domain / Interleukin-1 receptor family / TIR domain / Toll - interleukin 1 - resistance / Immunoglobulin domain / TIR domain profile. ...Interleukin-33 / Interleukin 33 / Interleukin-1 receptor type I/II / IL-1Ra-like, immunoglobulin domain / Immunoglobulin domain / Interleukin-1 receptor family / TIR domain / Toll - interleukin 1 - resistance / Immunoglobulin domain / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain / Toll/interleukin-1 receptor homology (TIR) domain superfamily / Immunoglobulin domain / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.792 Å |
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Authors | Guenther, S. / Sundberg, E.J. |
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Funding support | United States, 2items Organization | Grant number | Country |
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National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) | R01AR068436 | United States | American Asthma Foundation | 13-0066 | United States |
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Citation | Journal: Immunity / Year: 2017 Title: IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor. Authors: Gunther, S. / Deredge, D. / Bowers, A.L. / Luchini, A. / Bonsor, D.A. / Beadenkopf, R. / Liotta, L. / Wintrode, P.L. / Sundberg, E.J. |
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History | Deposition | Apr 13, 2017 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Sep 27, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 11, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.2 | Jul 29, 2020 | Group: Data collection / Derived calculations / Structure summary Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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Revision 1.3 | Oct 4, 2023 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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