Entry Database : PDB / ID : 6l6r Structure visualization Downloads & linksTitle Crystal structure of LRP6 E1E2-SOST complex ComponentsLow-density lipoprotein receptor-related protein 6 Sclerostin DetailsKeywords SIGNALING PROTEIN / LRP6 / Sclerostin / Wnt signaling / inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
Wnt-Frizzled-LRP5/6 complex / Negative regulation of TCF-dependent signaling by WNT ligand antagonists / Signaling by RNF43 mutants / neural crest formation / BMP binding / kinase inhibitor activity / toxin transmembrane transporter activity / Wnt receptor activity / low-density lipoprotein particle receptor activity / Wnt-protein binding ... Wnt-Frizzled-LRP5/6 complex / Negative regulation of TCF-dependent signaling by WNT ligand antagonists / Signaling by RNF43 mutants / neural crest formation / BMP binding / kinase inhibitor activity / toxin transmembrane transporter activity / Wnt receptor activity / low-density lipoprotein particle receptor activity / Wnt-protein binding / cellular response to cholesterol / midbrain dopaminergic neuron differentiation / negative regulation of protein serine/threonine kinase activity / dopaminergic neuron differentiation / frizzled binding / negative regulation of ossification / Wnt signalosome / neural crest cell differentiation / cellular response to parathyroid hormone stimulus / Disassembly of the destruction complex and recruitment of AXIN to the membrane / molecular function inhibitor activity / negative regulation of Wnt signaling pathway / negative regulation of smooth muscle cell apoptotic process / negative regulation of BMP signaling pathway / canonical Wnt signaling pathway / negative regulation of protein-containing complex assembly / BMP signaling pathway / coreceptor activity / positive regulation of cell cycle / response to mechanical stimulus / Regulation of FZD by ubiquitination / ossification / TCF dependent signaling in response to WNT / protein localization to plasma membrane / negative regulation of canonical Wnt signaling pathway / Wnt signaling pathway / response to peptide hormone / cell-cell adhesion / positive regulation of DNA-binding transcription factor activity / endocytosis / nervous system development / heparin binding / positive regulation of cytosolic calcium ion concentration / early endosome membrane / cytoplasmic vesicle / carbohydrate binding / chemical synaptic transmission / DNA-binding transcription factor binding / membrane raft / signaling receptor binding / neuronal cell body / synapse / positive regulation of DNA-templated transcription / Golgi apparatus / cell surface / endoplasmic reticulum / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / extracellular space / extracellular region / identical protein binding / plasma membrane Similarity search - Function Sclerostin/Sclerostin domain-containing protein 1 / Sclerostin (SOST) / Low density lipoprotein receptor-related protein 5/6 / : / Cystine knot, C-terminal / C-terminal cystine knot-like domain (CTCK) / Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / LDLR class B repeat / Low-density lipoprotein-receptor YWTD domain ... Sclerostin/Sclerostin domain-containing protein 1 / Sclerostin (SOST) / Low density lipoprotein receptor-related protein 5/6 / : / Cystine knot, C-terminal / C-terminal cystine knot-like domain (CTCK) / Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / LDLR class B repeat / Low-density lipoprotein-receptor YWTD domain / Low-density lipoprotein receptor domain class A / Low-density lipoprotein (LDL) receptor class A, conserved site / LDL-receptor class A (LDLRA) domain signature. / LDL-receptor class A (LDLRA) domain profile. / Low-density lipoprotein receptor domain class A / Cystine-knot cytokine / Low-density lipoprotein (LDL) receptor class A repeat / LDL receptor-like superfamily / Six-bladed beta-propeller, TolB-like / Coagulation Factor Xa inhibitory site / Epidermal growth factor-like domain. / EGF-like domain signature 2. / EGF-like domain Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 3.8 Å DetailsAuthors Choi, H.-J. / Kim, J. Funding support Korea, Republic Of, 2items Details Hide detailsOrganization Grant number Country National Research Foundation (NRF, Korea) NRF-2016R1A2B4013488 Korea, Republic Of National Research Foundation (NRF, Korea) NRF-2019M3E5D6063903 Korea, Republic Of
CitationJournal : Nat Commun / Year : 2020Title : Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains.Authors : Kim, J. / Han, W. / Park, T. / Kim, E.J. / Bang, I. / Lee, H.S. / Jeong, Y. / Roh, K. / Kim, J. / Kim, J.S. / Kang, C. / Seok, C. / Han, J.-K. / Choi, H.-J. History Deposition Oct 29, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Oct 28, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Nov 4, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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