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TitleSclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains.
Journal, issue, pagesNat Commun, Vol. 11, Page 5357-5357, Year 2020
Publish dateOct 29, 2019 (structure data deposition date)
AuthorsKim, J. / Han, W. / Park, T. / Kim, E.J. / Bang, I. / Lee, H.S. / Jeong, Y. / Roh, K. / Kim, J.S. / Kang, C. ...Kim, J. / Han, W. / Park, T. / Kim, E.J. / Bang, I. / Lee, H.S. / Jeong, Y. / Roh, K. / Kim, J.S. / Kang, C. / Seok, C. / Han, J.-K. / Choi, H.-J.
External linksNat Commun / PubMed:33097721
MethodsX-ray diffraction
Resolution3.8 Å
Structure data

PDB-6l6r:
Crystal structure of LRP6 E1E2-SOST complex
Method: X-RAY DIFFRACTION / Resolution: 3.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MG:
Unknown entry

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / LRP6 / Sclerostin / Wnt signaling / inhibitor

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