登録情報 データベース : PDB / ID : 5ula 構造の表示 ダウンロードとリンクタイトル Crystal Structure of the First Bromodomain of Human BRD4 in Complex With Cyclic Vinylogous Amide Inhibitor MS402 要素Bromodomain-containing protein 4 詳細 キーワード transcription/inhibitor / bromodomain / inhibitor / transcription / transcription-inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ... RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 1.5 Å 詳細データ登録者 Plotnikov, A.N. / Joshua, j. / Zhou, M.-M. 引用ジャーナル : Proc. Natl. Acad. Sci. U.S.A. / 年 : 2017タイトル : BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.著者: Cheung, K. / Lu, G. / Sharma, R. / Vincek, A. / Zhang, R. / Plotnikov, A.N. / Zhang, F. / Zhang, Q. / Ju, Y. / Hu, Y. / Zhao, L. / Han, X. / Meslamani, J. / Xu, F. / Jaganathan, A. / Shen, T. ... 著者 : Cheung, K. / Lu, G. / Sharma, R. / Vincek, A. / Zhang, R. / Plotnikov, A.N. / Zhang, F. / Zhang, Q. / Ju, Y. / Hu, Y. / Zhao, L. / Han, X. / Meslamani, J. / Xu, F. / Jaganathan, A. / Shen, T. / Zhu, H. / Rusinova, E. / Zeng, L. / Zhou, J. / Yang, J. / Peng, L. / Ohlmeyer, M. / Walsh, M.J. / Zhang, D.Y. / Xiong, H. / Zhou, M.M. 履歴 登録 2017年1月24日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2017年3月22日 Provider : repository / タイプ : Initial release改定 1.1 2024年3月6日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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