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Title | BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. U.S.A., Vol. 114, Page 2952-2957, Year 2017 |
Publish date | Jan 24, 2017 (structure data deposition date) |
Authors | Cheung, K. / Lu, G. / Sharma, R. / Vincek, A. / Zhang, R. / Plotnikov, A.N. / Zhang, F. / Zhang, Q. / Ju, Y. / Hu, Y. ...Cheung, K. / Lu, G. / Sharma, R. / Vincek, A. / Zhang, R. / Plotnikov, A.N. / Zhang, F. / Zhang, Q. / Ju, Y. / Hu, Y. / Zhao, L. / Han, X. / Meslamani, J. / Xu, F. / Jaganathan, A. / Shen, T. / Zhu, H. / Rusinova, E. / Zeng, L. / Zhou, J. / Yang, J. / Peng, L. / Ohlmeyer, M. / Walsh, M.J. / Zhang, D.Y. / Xiong, H. / Zhou, M.M. |
External links | Proc. Natl. Acad. Sci. U.S.A. / PubMed:28265070 |
Methods | X-ray diffraction |
Resolution | 1.5 Å |
Structure data | PDB-5ula: |
Chemicals | ChemComp-5MJ: ChemComp-HOH: |
Source |
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Keywords | transcription/inhibitor / bromodomain / inhibitor / transcription / transcription-inhibitor complex |