登録情報 | データベース: PDB / ID: 5u9m |
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タイトル | Copper-Zinc Superoxide Dismutase is Activated through a Sulfenic Acid Intermediate at a Copper-ion Entry Site |
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要素 | - Superoxide dismutase 1 copper chaperone
- Superoxide dismutase [Cu-Zn]
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キーワード | oxidoreductase/chaperone / oxidoreductase-chaperone complex / Cu-Zn superoxide dismutase / metallochaperone |
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機能・相同性 | 機能・相同性情報
superoxide dismutase complex / protein maturation by copper ion transfer / superoxide dismutase copper chaperone activity / Detoxification of Reactive Oxygen Species / copper ion transport / action potential initiation / neurofilament cytoskeleton organization / regulation of organ growth / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / protein phosphatase 2B binding ...superoxide dismutase complex / protein maturation by copper ion transfer / superoxide dismutase copper chaperone activity / Detoxification of Reactive Oxygen Species / copper ion transport / action potential initiation / neurofilament cytoskeleton organization / regulation of organ growth / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / protein phosphatase 2B binding / relaxation of vascular associated smooth muscle / response to superoxide / retrograde axonal transport / anterograde axonal transport / peripheral nervous system myelin maintenance / regulation of T cell differentiation in thymus / retina homeostasis / auditory receptor cell stereocilium organization / superoxide anion generation / hydrogen peroxide biosynthetic process / myeloid cell homeostasis / protein folding chaperone complex / regulation of GTPase activity / muscle cell cellular homeostasis / heart contraction / superoxide metabolic process / negative regulation of reproductive process / negative regulation of developmental process / superoxide dismutase / Detoxification of Reactive Oxygen Species / transmission of nerve impulse / superoxide dismutase activity / ectopic germ cell programmed cell death / neuronal action potential / regulation of multicellular organism growth / response to axon injury / ovarian follicle development / positive regulation of phagocytosis / axon cytoplasm / embryo implantation / glutathione metabolic process / dendrite cytoplasm / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / removal of superoxide radicals / reactive oxygen species metabolic process / thymus development / regulation of mitochondrial membrane potential / positive regulation of superoxide anion generation / determination of adult lifespan / positive regulation of cytokine production / locomotory behavior / sensory perception of sound / placenta development / response to hydrogen peroxide / mitochondrial intermembrane space / small GTPase binding / negative regulation of inflammatory response / regulation of blood pressure / Platelet degranulation / peroxisome / protein-folding chaperone binding / gene expression / response to heat / cytoplasmic vesicle / spermatogenesis / response to ethanol / intracellular iron ion homeostasis / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade / mitochondrial inner membrane / mitochondrial matrix / positive regulation of apoptotic process / response to xenobiotic stimulus / copper ion binding / neuronal cell body / apoptotic process / protein-containing complex / mitochondrion / extracellular space / extracellular exosome / zinc ion binding / extracellular region / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Heavy-metal-associated domain / Heavy metal-associated domain superfamily / Heavy-metal-associated domain profile. / Heavy metal-associated domain, HMA / Copper/Zinc superoxide dismutase signature 1. / Superoxide dismutase, copper/zinc, binding site / Copper/Zinc superoxide dismutase signature 2. / Superoxide dismutase, copper/zinc binding domain / Copper/zinc superoxide dismutase (SODC) / Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone / Superoxide dismutase-like, copper/zinc binding domain superfamily類似検索 - ドメイン・相同性 Superoxide dismutase [Cu-Zn] / Superoxide dismutase 1 copper chaperone類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Saccharomyces cerevisiae (パン酵母) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.35 Å |
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データ登録者 | Taylor, A.B. / Hart, P.J. / Winkler, D.D. |
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引用 | ジャーナル: J. Biol. Chem. / 年: 2017 タイトル: Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper ion entry site. 著者: Fetherolf, M.M. / Boyd, S.D. / Taylor, A.B. / Kim, H.J. / Wohlschlegel, J.A. / Blackburn, N.J. / Hart, P.J. / Winge, D.R. / Winkler, D.D. |
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履歴 | 登録 | 2016年12月16日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年5月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年6月7日 | Group: Database references |
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改定 1.2 | 2017年8月2日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title |
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改定 1.3 | 2023年10月4日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry |
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