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- PDB-3sd0: Identification of a Glycogen Synthase Kinase-3b Inhibitor that At... -

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Basic information

Entry
Database: PDB / ID: 3sd0
TitleIdentification of a Glycogen Synthase Kinase-3b Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice
ComponentsGlycogen synthase kinase-3 beta
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex
Function / homology
Function and homology information


neuron projection organization / regulation of microtubule anchoring at centrosome / negative regulation of type B pancreatic cell development / negative regulation of glycogen (starch) synthase activity / negative regulation of mesenchymal stem cell differentiation / superior temporal gyrus development / positive regulation of protein localization to cilium / negative regulation of glycogen biosynthetic process / negative regulation of TORC2 signaling / negative regulation of dopaminergic neuron differentiation ...neuron projection organization / regulation of microtubule anchoring at centrosome / negative regulation of type B pancreatic cell development / negative regulation of glycogen (starch) synthase activity / negative regulation of mesenchymal stem cell differentiation / superior temporal gyrus development / positive regulation of protein localization to cilium / negative regulation of glycogen biosynthetic process / negative regulation of TORC2 signaling / negative regulation of dopaminergic neuron differentiation / maintenance of cell polarity / positive regulation of protein localization to centrosome / positive regulation of cilium assembly / beta-catenin destruction complex / CRMPs in Sema3A signaling / heart valve development / APC truncation mutants have impaired AXIN binding / AXIN missense mutants destabilize the destruction complex / Truncations of AMER1 destabilize the destruction complex / tau-protein kinase / regulation of microtubule-based process / regulation of protein export from nucleus / positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / Beta-catenin phosphorylation cascade / Signaling by GSK3beta mutants / CTNNB1 S33 mutants aren't phosphorylated / CTNNB1 S37 mutants aren't phosphorylated / CTNNB1 S45 mutants aren't phosphorylated / CTNNB1 T41 mutants aren't phosphorylated / Maturation of nucleoprotein / cellular response to interleukin-3 / Wnt signalosome / regulation of long-term synaptic potentiation / negative regulation of TOR signaling / negative regulation of protein localization to nucleus / Disassembly of the destruction complex and recruitment of AXIN to the membrane / AKT phosphorylates targets in the cytosol / negative regulation of calcineurin-NFAT signaling cascade / regulation of axon extension / Maturation of nucleoprotein / tau-protein kinase activity / G protein-coupled dopamine receptor signaling pathway / negative regulation of epithelial to mesenchymal transition / positive regulation of cell-matrix adhesion / regulation of axonogenesis / regulation of dendrite morphogenesis / glycogen metabolic process / ER overload response / regulation of neuron projection development / establishment of cell polarity / protein kinase A catalytic subunit binding / Constitutive Signaling by AKT1 E17K in Cancer / dynactin binding / epithelial to mesenchymal transition / Regulation of HSF1-mediated heat shock response / negative regulation of osteoblast differentiation / NF-kappaB binding / canonical Wnt signaling pathway / negative regulation of protein-containing complex assembly / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / regulation of cellular response to heat / extrinsic apoptotic signaling pathway / cellular response to retinoic acid / extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of autophagy / presynaptic modulation of chemical synaptic transmission / Transcriptional and post-translational regulation of MITF-M expression and activity / regulation of microtubule cytoskeleton organization / response to endoplasmic reticulum stress / negative regulation of cell migration / positive regulation of protein export from nucleus / hippocampus development / positive regulation of protein ubiquitination / excitatory postsynaptic potential / Ubiquitin-dependent degradation of Cyclin D / mitochondrion organization / positive regulation of cell differentiation / positive regulation of protein-containing complex assembly / histone H4S1 kinase activity / histone H2BS14 kinase activity / histone H2AS121 kinase activity / histone H3S57 kinase activity / eukaryotic translation initiation factor 2alpha kinase activity / histone H3S28 kinase activity / histone H2AS1 kinase activity / GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 / negative regulation of canonical Wnt signaling pathway / histone H3T6 kinase activity / ribosomal protein S6 kinase activity / histone H2AT120 kinase activity / histone H2BS36 kinase activity / Rho-dependent protein serine/threonine kinase activity / histone H3S10 kinase activity / AMP-activated protein kinase activity / 3-phosphoinositide-dependent protein kinase activity / histone H3T11 kinase activity / histone H3T3 kinase activity / Degradation of GLI2 by the proteasome / GLI3 is processed to GLI3R by the proteasome / histone H3T45 kinase activity
Similarity search - Function
Glycogen synthase kinase 3, catalytic domain / : / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ...Glycogen synthase kinase 3, catalytic domain / : / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta
Similarity search - Domain/homology
Chem-TSK / Glycogen synthase kinase-3 beta
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.7 Å
AuthorsMesecar, A.M. / Walters, R.L.
CitationJournal: To be Published
Title: Identification of a Glycogen Synthase Kinase-3b Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice
Authors: Mesecar, A.M. / Walters, R.L.
History
DepositionJun 8, 2011Deposition site: RCSB / Processing site: RCSB
Revision 1.0Aug 3, 2011Provider: repository / Type: Initial release
Revision 1.1Feb 28, 2024Group: Data collection / Database references / Derived calculations
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Glycogen synthase kinase-3 beta
B: Glycogen synthase kinase-3 beta
hetero molecules


Theoretical massNumber of molelcules
Total (without water)81,1156
Polymers79,6062
Non-polymers1,5094
Water5,116284
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
A: Glycogen synthase kinase-3 beta
hetero molecules


Theoretical massNumber of molelcules
Total (without water)40,5573
Polymers39,8031
Non-polymers7552
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
3
B: Glycogen synthase kinase-3 beta
hetero molecules


Theoretical massNumber of molelcules
Total (without water)40,5573
Polymers39,8031
Non-polymers7552
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
Unit cell
Length a, b, c (Å)88.505, 96.010, 124.249
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number18
Space group name H-MP21221

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Components

#1: Protein Glycogen synthase kinase-3 beta / GSK-3 beta


Mass: 39802.793 Da / Num. of mol.: 2 / Fragment: UNP residues 35-384
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: GSK3B / Production host: Spodoptera frugiperda (fall armyworm) / References: UniProt: P49841, tau-protein kinase
#2: Chemical ChemComp-TSK / 3-(5-fluoro-6-iodo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione


Mass: 516.260 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C22H14FIN2O4
#3: Chemical ChemComp-EPE / 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES


Mass: 238.305 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C8H18N2O4S / Comment: pH buffer*YM
#4: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 284 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.32 Å3/Da / Density % sol: 62.9 %

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 22-ID
DetectorType: MARMOSAIC 300 mm CCD / Detector: CCD
RadiationMonochromator: double crystal Si (111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthRelative weight: 1
ReflectionResolution: 2.7→50 Å / Num. all: 29833 / Num. obs: 29057 / % possible obs: 97.4 % / Observed criterion σ(F): 2 / Observed criterion σ(I): 2

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Processing

Software
NameVersionClassificationNB
REFMAC5.2.0019refinement
PDB_EXTRACT3.1data extraction
SERGUIdata collection
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.7→44.95 Å / Cor.coef. Fo:Fc: 0.952 / Cor.coef. Fo:Fc free: 0.91 / Occupancy max: 1 / Occupancy min: 0.6 / SU B: 22.235 / SU ML: 0.238 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.636 / ESU R Free: 0.328 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
RfactorNum. reflection% reflectionSelection details
Rfree0.254 1473 5.1 %RANDOM
Rwork0.1786 ---
obs0.1786 28995 97.36 %-
all-27522 --
Solvent computationIon probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: MASK
Displacement parametersBiso max: 147.24 Å2 / Biso mean: 57.1652 Å2 / Biso min: 21.7 Å2
Baniso -1Baniso -2Baniso -3
1--0.6 Å20 Å20 Å2
2---0.05 Å20 Å2
3---0.65 Å2
Refinement stepCycle: LAST / Resolution: 2.7→44.95 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms5592 0 90 284 5966
Refine LS restraints
Refine-IDTypeDev idealDev ideal targetNumber
X-RAY DIFFRACTIONr_bond_refined_d0.0140.0225833
X-RAY DIFFRACTIONr_angle_refined_deg1.9391.9977948
X-RAY DIFFRACTIONr_dihedral_angle_1_deg6.3795697
X-RAY DIFFRACTIONr_dihedral_angle_2_deg35.74323.02255
X-RAY DIFFRACTIONr_dihedral_angle_3_deg17.95415964
X-RAY DIFFRACTIONr_dihedral_angle_4_deg19.3811546
X-RAY DIFFRACTIONr_chiral_restr0.1040.2877
X-RAY DIFFRACTIONr_gen_planes_refined0.0060.024428
X-RAY DIFFRACTIONr_nbd_refined0.2430.22878
X-RAY DIFFRACTIONr_nbtor_refined0.3240.23987
X-RAY DIFFRACTIONr_xyhbond_nbd_refined0.2320.2322
X-RAY DIFFRACTIONr_symmetry_vdw_refined0.2380.256
X-RAY DIFFRACTIONr_symmetry_hbond_refined0.2460.210
X-RAY DIFFRACTIONr_mcbond_it0.6471.53533
X-RAY DIFFRACTIONr_mcangle_it1.1925741
X-RAY DIFFRACTIONr_scbond_it2.04132565
X-RAY DIFFRACTIONr_scangle_it3.0274.52207
LS refinement shellResolution: 2.7→2.769 Å / Total num. of bins used: 20
RfactorNum. reflection% reflection
Rfree0.337 89 -
Rwork0.261 1952 -
all-2041 -
obs--93.84 %
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
117.3214-6.2725-0.588813.13336.65778.71280.12910.17930.67060.3033-0.4707-0.08430.0801-0.56920.34160.1817-0.09810.0037-0.04670.06720.03813.4126-56.2976-19.0094
22.42960.559-1.560524.05084.39824.87760.0929-0.437-0.1210.4376-0.0953-0.20550.4619-0.28690.00240.0879-0.1224-0.04230.33920.0074-0.10744.9384-55.2842-17.5266
310.18692.2779-1.4743.41421.62553.31440.5061-0.34550.43710.2665-0.04280.441-0.4345-0.2104-0.46330.0325-0.0120.00190.0887-0.12280.09046.7214-46.3566-16.036
44.97410.77722.14876.43830.27726.61360.15070.67920.3442-1.3077-0.0424-0.5364-0.19450.8465-0.10830.1296-0.03420.02850.06660.01020.138313.404-49.3347-29.4258
59.87226.7527-12.17384.6189-8.327115.01210.15320.4751-0.6182-0.57840.2731-0.46560.8578-0.1954-0.42640.084-0.0172-0.0750.0837-0.05230.172320.3782-54.3386-25.4619
64.7820.05032.70990.74850.56991.92760.2924-0.5932-0.59150.3405-0.1571-0.00570.1566-0.0385-0.13520.1133-0.0666-0.01960.11180.00980.130917.3332-54.877-15.0469
79.51332.8431-3.785512.5233-9.27719.4236-0.71911.57931.0955-0.69620.98830.776-0.5072-1.6411-0.26920.1628-0.0831-0.03940.20.07860.10725.4171-47.9768-34.2383
83.68653.60193.56663.77424.29136.00190.0133-0.60420.5348-0.0915-0.28010.5242-0.3876-0.37980.26690.0929-0.0053-0.00130.1208-0.12770.228114.7325-40.7608-12.9964
910.2508-17.655811.117842.6551-11.570916.7482-0.9801-0.27550.49380.640.57290.0399-1.2868-0.5810.40720.0168-0.12910.12720.153-0.08080.035224.2205-29.43770.2734
101.01840.41251.04841.52550.47571.08130.0733-0.1939-0.06470.287-0.1228-0.16510.1531-0.14540.04950.1415-0.0398-0.00630.13470.00230.066529.9474-47.4815-11.0187
113.94940.0928-1.96792.81820.57317.76770.1182-0.18790.03160.2016-0.10920.22090.0589-0.4908-0.0090.0888-0.0408-0.03170.1164-0.03830.087824.1261-44.432-14.632
127.36050.55632.68162.8621-2.03523.8164-0.1369-0.209-0.2793-0.12190.01920.3360.06260.12750.11760.13720.008-0.01610.08140.00780.056131.58-40.7989-28.6751
131.38321.122.28880.27234.12090.09480.139-0.0334-0.0715-0.0325-0.405-0.10420.219-0.06230.1427-0.0002-0.02160.1148-0.02520.066736.0982-36.4417-24.6521
141.0270.4895-0.15910.2352-0.01551.93740.056-0.04220.12880.0681-0.115-0.0272-0.2876-0.10760.0590.11370.0148-0.01270.1111-0.0390.089834.553-31.2686-15.8117
152.05180.21910.39881.31543.37978.6970.0118-0.0134-0.0419-0.1124-0.0642-0.3512-0.16080.29710.05230.09290.01370.01540.09310.0090.139848.0881-32.9673-25.5994
165.5764-0.108-4.67030.1172.482753.69450.13720.15930.1455-0.0445-0.0727-0.1071-2.36552.0431-0.06450.194-0.1072-0.0454-0.01880.07080.094847.13-24.5969-16.1914
171.83460.2515-0.59651.33070.78194.22750.0773-0.15260.07480.3108-0.1758-0.05960.0365-0.14980.09850.1141-0.0215-0.07440.1386-0.00630.089639.9331-37.9705-5.3975
183.0948-3.3936-5.4816.4784.200210.8956-0.224-0.5658-0.55010.48490.20120.70280.0543-0.93690.02280.212-0.30970.12710.24360.09750.046825.2201-45.96528.3444
191.81691.05-3.50940.9513-1.25028.53470.2753-0.7386-0.7866-0.1459-0.4679-0.15490.43150.6270.19260.1201-0.0509-0.0260.08640.05930.10835.5983-56.4803-3.9075
2039.932234.505313.29441.2306-6.039631.33791.4107-2.1397-5.0442.1757-0.145-1.66160.2495-0.3572-1.26570.3693-0.221-0.13310.26280.30940.103933.7304-58.54428.6708
216.41711.6238-1.04817.4199-0.280815.8216-0.0033-0.20440.59890.4455-0.33360.67520.2305-0.9610.3369-0.0817-0.02080.08080.0451-0.00090.346843.22094.7369-23.2858
2218.35543.7238-13.11486.40670.42218.1084-0.17560.86760.5501-0.6791-0.0660.3625-0.1194-0.59630.24160.085-0.0677-0.0677-0.02190.02830.321244.98675.904-26.8247
235.98780.49310.526312.54223.00393.05960.4436-0.61550.33951.1245-0.88840.6117-0.0169-0.48660.4448-0.0031-0.11450.13990.1987-0.22020.221934.075-1.5946-20.9981
2410.9755-4.28933.91514.6757-3.69865.84360.53010.5015-0.80850.1535-0.5358-0.51640.82390.90470.00570.1302-0.0264-0.03320.0253-0.02390.051144.9179-9.6907-24.6492
251.58183.96412.50423.39620.14166.75870.44320.4694-0.0626-0.0179-0.4679-1.2010.01440.48940.02470.05510.01860.07980.0380.03780.102945.2271-10.5916-33.8654
265.83982.21683.76631.12970.56185.0432-0.30960.36840.232-0.36380.17080.0506-0.68740.11740.13880.1179-0.01440.0879-0.01320.00690.238138.1006-2.5122-35.288
274.9206-5.44910.964819.9914-18.35327.1970.4496-2.0262-0.3372.2584-0.1258-0.8843-0.4203-0.3438-0.32370.258-0.1581-0.04770.38440.04810.134249.2694-7.8376-15.7612
2822.30683.38543.59280.53820.54310.57890.5795-1.01090.76830.176-0.51740.2245-0.1745-0.4766-0.06210.04490.01620.06340.1669-0.07490.311932.5292-3.6318-27.4426
2931.4549-6.0964-13.0189.3355-3.33899.6019-0.0343-0.787-0.87210.7874-0.03740.4691-0.5952-0.25160.07170.14540.0229-0.03330.0947-0.05250.07113.7293-12.885-26.5118
301.18970.17731.4452.5840.49751.78620.0947-0.08890.4625-0.1764-0.0440.48460.0311-0.1777-0.05070.08110.0497-0.01210.0630.03060.174219.6495-10.1696-41.1093
315.7235-3.6241-0.89514.40630.03262.1703-0.0530.06890.3727-0.03580.051-0.0619-0.0828-0.19260.0020.0777-0.0043-0.00530.07390.00270.159228.9234-10.8893-36.256
3212.2371-11.6109-7.036411.55247.620510.72430.5110.84950.4294-0.4381-0.4323-0.46780.5158-0.0846-0.07870.12030.00780.04350.11520.05660.143641.1737-19.9199-39.2612
331.17150.03550.69472.0168-0.25430.44960.0653-0.0314-0.0543-0.0442-0.03910.04980.0975-0.062-0.02620.14730.0382-0.00540.1267-0.01460.089326.1689-27.278-35.2212
347.4982-3.9031.85915.16840.54765.69680.34120.8073-0.4188-0.6172-0.3120.14990.510.291-0.02920.15990.0317-0.04230.0607-0.08910.07228.0731-39.3001-43.5478
3511.3449-7.89163.755810.6553-1.72574.15020.2782-0.0366-1.0848-0.5421-0.05532.04110.3015-0.7228-0.22290.0002-0.0608-0.04180.04170.01950.213813.1667-33.5017-40.6743
3630.6891-0.6949-2.10566.09940.46010.17240.93090.0745-0.2159-1.0501-0.62110.5451-0.0872-0.0806-0.30980.13910.1054-0.06810.1839-0.01730.026614.4902-21.0808-47.1534
370.13410.3877-0.39077.09430.1121.3966-0.0520.37180.2532-0.8720.2584-0.00720.0843-0.2535-0.20640.16450.0603-0.03750.1393-0.01870.026826.4235-25.4753-47.6304
3813.6516-1.8097-0.74557.09653.69441.92620.21191.17130.8821-0.922-0.37030.0691-0.1081-0.11080.15840.18560.0689-0.0720.09140.14350.086318.7618-13.9002-50.6706
397.8436-2.637-3.47923.09432.67133.77840.25650.61061.1424-0.6903-0.0923-0.1243-0.2353-0.1205-0.16420.14130.0851-0.00240.02060.20060.108622.1042-3.9489-50.0582
4025.02617.8624-13.390613.51941.481310.0931-0.30241.69023.4069-2.10132.30340.2787-1.98270.1651-2.0010.50390.32540.02670.19260.46010.173821.818-1.0739-57.1564
Refinement TLS group
IDRefine-IDRefine TLS-IDAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1A35 - 46
2X-RAY DIFFRACTION2A47 - 62
3X-RAY DIFFRACTION3A63 - 81
4X-RAY DIFFRACTION4A82 - 93
5X-RAY DIFFRACTION5A94 - 102
6X-RAY DIFFRACTION6A103 - 116
7X-RAY DIFFRACTION7A117 - 126
8X-RAY DIFFRACTION8A127 - 145
9X-RAY DIFFRACTION9A146 - 157
10X-RAY DIFFRACTION10A158 - 180
11X-RAY DIFFRACTION11A181 - 209
12X-RAY DIFFRACTION12A210 - 220
13X-RAY DIFFRACTION13A221 - 234
14X-RAY DIFFRACTION14A235 - 270
15X-RAY DIFFRACTION15A271 - 291
16X-RAY DIFFRACTION16A292 - 302
17X-RAY DIFFRACTION17A303 - 343
18X-RAY DIFFRACTION18A344 - 358
19X-RAY DIFFRACTION19A359 - 379
20X-RAY DIFFRACTION20A380 - 384
21X-RAY DIFFRACTION21B35 - 46
22X-RAY DIFFRACTION22B47 - 58
23X-RAY DIFFRACTION23B59 - 80
24X-RAY DIFFRACTION24B81 - 93
25X-RAY DIFFRACTION25B94 - 102
26X-RAY DIFFRACTION26B103 - 116
27X-RAY DIFFRACTION27B117 - 127
28X-RAY DIFFRACTION28B128 - 138
29X-RAY DIFFRACTION29B139 - 150
30X-RAY DIFFRACTION30B151 - 171
31X-RAY DIFFRACTION31B172 - 199
32X-RAY DIFFRACTION32B200 - 211
33X-RAY DIFFRACTION33B212 - 270
34X-RAY DIFFRACTION34B271 - 290
35X-RAY DIFFRACTION35B291 - 308
36X-RAY DIFFRACTION36B309 - 320
37X-RAY DIFFRACTION37B321 - 332
38X-RAY DIFFRACTION38B333 - 341
39X-RAY DIFFRACTION39B342 - 376
40X-RAY DIFFRACTION40B377 - 383

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