Entry Database : PDB / ID : 5u78 Structure visualization Downloads & linksTitle Crystal structure of ORP8 PH domain in P1211 space group ComponentsOxysterol-binding protein-related protein 8 Details Keywords LIPID TRANSPORT / Oxsyterol / membrane contact site / Phosphoinositide.Function / homology Function and homology informationFunction Domain/homology Component
phosphatidylserine acyl-chain remodeling / phosphatidylserine transfer activity / Acyl chain remodelling of PS / : / protein localization to nuclear pore / phospholipid transporter activity / cortical endoplasmic reticulum / phospholipid transport / phosphatidylinositol-4-phosphate binding / negative regulation of sequestering of triglyceride ... phosphatidylserine acyl-chain remodeling / phosphatidylserine transfer activity / Acyl chain remodelling of PS / : / protein localization to nuclear pore / phospholipid transporter activity / cortical endoplasmic reticulum / phospholipid transport / phosphatidylinositol-4-phosphate binding / negative regulation of sequestering of triglyceride / cholesterol binding / fat cell differentiation / phosphatidylserine binding / positive regulation of insulin receptor signaling pathway / negative regulation of cell migration / positive regulation of glucose import / nuclear membrane / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / endoplasmic reticulum membrane / endoplasmic reticulum / membrane / cytosol Similarity search - Function Oxysterol-binding protein / Oxysterol-binding protein, conserved site / Oxysterol-binding protein superfamily / Oxysterol-binding protein / Oxysterol-binding protein family signature. / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / PH domain / PH domain profile. / Pleckstrin homology domain. ... Oxysterol-binding protein / Oxysterol-binding protein, conserved site / Oxysterol-binding protein superfamily / Oxysterol-binding protein / Oxysterol-binding protein family signature. / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / PH-like domain superfamily / Roll / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.978 Å DetailsAuthors Ghai, R. / Yang, H. Funding support Australia, 3items Details Hide detailsOrganization Grant number Country National Health and Medical Research Council (NHMRC, Australia) 1097185 Australia National Health and Medical Research Council (NHMRC, Australia) 1041301 Australia Australian Research Council (ARC) DP130100457 Australia
CitationJournal : Nat Commun / Year : 2017Title : ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane.Authors : Ghai, R. / Du, X. / Wang, H. / Dong, J. / Ferguson, C. / Brown, A.J. / Parton, R.G. / Wu, J.W. / Yang, H. History Deposition Dec 12, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 18, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jan 17, 2018 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.2 Jan 1, 2020 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.3 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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