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TitleORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane.
Journal, issue, pagesNat Commun, Vol. 8, Page 757-757, Year 2017
Publish dateDec 11, 2016 (structure data deposition date)
AuthorsGhai, R. / Du, X. / Wang, H. / Dong, J. / Ferguson, C. / Brown, A.J. / Parton, R.G. / Wu, J.W. / Yang, H.
External linksNat Commun / PubMed:28970484
MethodsX-ray diffraction
Resolution1.978 - 2.157 Å
Structure data

PDB-5u77:
Crystal structure of ORP8 PH domain
Method: X-RAY DIFFRACTION / Resolution: 2.157 Å

PDB-5u78:
Crystal structure of ORP8 PH domain in P1211 space group
Method: X-RAY DIFFRACTION / Resolution: 1.978 Å

Chemicals

ChemComp-NDB:
N-(2-hydroxyethyl)-N,N-dimethyl-3-sulfopropan-1-aminium

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIPID TRANSPORT / Oxsyterol / membrane contact site / Phosphoinositide / Phosphoinositide.

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