Entry | Database: PDB / ID: 5t8o |
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Title | Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to Imidazobenzoxepin Compound 3 |
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Components | Mitogen-activated protein kinase kinase kinase 14 |
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Keywords | TRANSFERASE / protein serine/threonine kinase / NF-kappaB / MAP3K14 |
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Function / homology | Function and homology information
CD28 dependent PI3K/Akt signaling / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / Dectin-1 mediated noncanonical NF-kB signaling / NIK-->noncanonical NF-kB signaling / TNFR2 non-canonical NF-kB pathway / mitogen-activated protein kinase kinase kinase / MAP kinase kinase kinase activity / non-canonical NF-kappaB signal transduction / canonical NF-kappaB signal transduction / cellular response to mechanical stimulus ...CD28 dependent PI3K/Akt signaling / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / Dectin-1 mediated noncanonical NF-kB signaling / NIK-->noncanonical NF-kB signaling / TNFR2 non-canonical NF-kB pathway / mitogen-activated protein kinase kinase kinase / MAP kinase kinase kinase activity / non-canonical NF-kappaB signal transduction / canonical NF-kappaB signal transduction / cellular response to mechanical stimulus / fibrillar center / defense response to virus / protein kinase activity / immune response / protein serine kinase activity / protein serine/threonine kinase activity / nucleoplasm / ATP binding / cytosolSimilarity search - Function Mitogen-activated protein (MAP) kinase kinase kinase 14 / M3K14, catalytic domain / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain ...Mitogen-activated protein (MAP) kinase kinase kinase 14 / M3K14, catalytic domain / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.41 Å |
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Authors | Smith, M.A. / McEwan, P. / Hymowitz, S.G. |
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Citation | Journal: J. Med. Chem. / Year: 2017 Title: Structure-Based Design of Tricyclic NF-kappa B Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K). Authors: Castanedo, G.M. / Blaquiere, N. / Beresini, M. / Bravo, B. / Brightbill, H. / Chen, J. / Cui, H.F. / Eigenbrot, C. / Everett, C. / Feng, J. / Godemann, R. / Gogol, E. / Hymowitz, S. / ...Authors: Castanedo, G.M. / Blaquiere, N. / Beresini, M. / Bravo, B. / Brightbill, H. / Chen, J. / Cui, H.F. / Eigenbrot, C. / Everett, C. / Feng, J. / Godemann, R. / Gogol, E. / Hymowitz, S. / Johnson, A. / Kayagaki, N. / Kohli, P.B. / Knuppel, K. / Kraemer, J. / Kruger, S. / Loke, P. / McEwan, P. / Montalbetti, C. / Roberts, D.A. / Smith, M. / Steinbacher, S. / Sujatha-Bhaskar, S. / Takahashi, R. / Wang, X. / Wu, L.C. / Zhang, Y. / Staben, S.T. |
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History | Deposition | Sep 8, 2016 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jan 11, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 25, 2017 | Group: Database references |
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Revision 1.2 | Feb 8, 2017 | Group: Database references |
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Revision 1.3 | May 8, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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