登録情報 | データベース: PDB / ID: 5svs |
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タイトル | Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel |
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要素 | P2X purinoceptor 3 |
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キーワード | MEMBRANE PROTEIN / Ion Channel / Anomalous Signal Mg ion |
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機能・相同性 | 機能・相同性情報
Platelet homeostasis / purinergic nucleotide receptor activity / extracellularly ATP-gated monoatomic cation channel activity / neuromuscular synaptic transmission / Elevation of cytosolic Ca2+ levels / peristalsis / urinary bladder smooth muscle contraction / response to carbohydrate / inorganic cation transmembrane transport / cellular response to ATP ...Platelet homeostasis / purinergic nucleotide receptor activity / extracellularly ATP-gated monoatomic cation channel activity / neuromuscular synaptic transmission / Elevation of cytosolic Ca2+ levels / peristalsis / urinary bladder smooth muscle contraction / response to carbohydrate / inorganic cation transmembrane transport / cellular response to ATP / positive regulation of calcium ion transport into cytosol / behavioral response to pain / protein homotrimerization / positive regulation of calcium-mediated signaling / response to mechanical stimulus / hippocampal mossy fiber to CA3 synapse / response to cold / establishment of localization in cell / calcium ion transmembrane transport / Schaffer collateral - CA1 synapse / regulation of synaptic plasticity / sensory perception of taste / response to heat / postsynapse / receptor complex / response to hypoxia / axon / signal transduction / ATP binding / plasma membrane類似検索 - 分子機能 P2X3 purinoceptor / ATP P2X receptor / ATP P2X receptors signature. / P2X purinoreceptor / P2X purinoreceptor extracellular domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 4.025 Å |
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データ登録者 | Mansoor, S.E. / Lu, W. / Oosterheert, W. / Shekhar, M. / Tajkhorshid, E. / Gouaux, E. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | 5F32GM108391 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM100400 | 米国 |
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引用 | ジャーナル: Nature / 年: 2016 タイトル: X-ray structures define human P2X3 receptor gating cycle and antagonist action. 著者: Mansoor, S.E. / Lu, W. / Oosterheert, W. / Shekhar, M. / Tajkhorshid, E. / Gouaux, E. |
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履歴 | 登録 | 2016年8月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年9月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年10月19日 | Group: Database references |
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改定 1.2 | 2017年9月20日 | Group: Author supporting evidence / Database references / Derived calculations カテゴリ: citation / pdbx_audit_support / pdbx_struct_oper_list Item: _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.3 | 2019年12月25日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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