登録情報 | データベース: PDB / ID: 5ott |
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タイトル | Extracellular domain of GLP-1 receptor in complex with exendin-4 variant Gly2Hcs/Thr5Hcs |
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要素 | - Exendin-4
- Glucagon-like peptide 1 receptor
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キーワード | SIGNALING PROTEIN / glucagon-like peptide 1 / GPCR / cyclic peptides |
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機能・相同性 | 機能・相同性情報
glucagon-like peptide 1 receptor activity / glucagon receptor activity / hormone secretion / positive regulation of blood pressure / post-translational protein targeting to membrane, translocation / response to psychosocial stress / regulation of heart contraction / peptide hormone binding / activation of adenylate cyclase activity / negative regulation of blood pressure ...glucagon-like peptide 1 receptor activity / glucagon receptor activity / hormone secretion / positive regulation of blood pressure / post-translational protein targeting to membrane, translocation / response to psychosocial stress / regulation of heart contraction / peptide hormone binding / activation of adenylate cyclase activity / negative regulation of blood pressure / cAMP-mediated signaling / regulation of blood pressure / adenylate cyclase-activating G protein-coupled receptor signaling pathway / hormone activity / transmembrane signaling receptor activity / Glucagon-type ligand receptors / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / positive regulation of cytosolic calcium ion concentration / G alpha (s) signalling events / toxin activity / learning or memory / cell surface receptor signaling pathway / extracellular region / membrane / plasma membrane類似検索 - 分子機能 : / GPCR, family 2, glucagon-like peptide-1 receptor / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / GPCR, family 2, glucagon-like peptide-1/glucagon receptor / : / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain ...: / GPCR, family 2, glucagon-like peptide-1 receptor / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / GPCR, family 2, glucagon-like peptide-1/glucagon receptor / : / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2.類似検索 - ドメイン・相同性 Exendin-4 / Glucagon-like peptide 1 receptor類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Heloderma suspectum (爬虫類) |
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手法 | X線回折 / 分子置換 / 解像度: 1.92 Å |
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データ登録者 | Mortensen, S. |
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引用 | ジャーナル: Biochemistry / 年: 2018 タイトル: alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4. 著者: Oddo, A. / Mortensen, S. / Thogersen, H. / De Maria, L. / Hennen, S. / McGuire, J.N. / Kofoed, J. / Linderoth, L. / Reedtz-Runge, S. |
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履歴 | 登録 | 2017年8月22日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2018年7月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年7月25日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.2 | 2024年1月17日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.3 | 2024年3月6日 | Group: Structure summary / カテゴリ: chem_comp / Item: _chem_comp.pdbx_synonyms |
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