Entry Database : PDB / ID : 5mez Structure visualization Downloads & linksTitle Crystal structure of Smad4-MH1 bound to the GGCT site. ComponentsDNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3')MH1 domain of human Smad4 DetailsKeywords TRANSCRIPTION / Smads / transcription factor / DNA complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of cell proliferation involved in heart valve morphogenesis / female gonad morphogenesis / negative regulation of cardiac myofibril assembly / metanephric mesenchyme morphogenesis / nephrogenic mesenchyme morphogenesis / somite rostral/caudal axis specification / atrioventricular valve formation / mesendoderm development / activin responsive factor complex / SMAD4 MH2 Domain Mutants in Cancer ... positive regulation of cell proliferation involved in heart valve morphogenesis / female gonad morphogenesis / negative regulation of cardiac myofibril assembly / metanephric mesenchyme morphogenesis / nephrogenic mesenchyme morphogenesis / somite rostral/caudal axis specification / atrioventricular valve formation / mesendoderm development / activin responsive factor complex / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer / positive regulation of luteinizing hormone secretion / regulation of hair follicle development / filamin binding / sebaceous gland development / SMAD protein complex / formation of anatomical boundary / epithelial cell migration / RUNX2 regulates bone development / positive regulation of follicle-stimulating hormone secretion / heteromeric SMAD protein complex / regulation of transforming growth factor beta2 production / neuron fate specification / RUNX3 regulates BCL2L11 (BIM) transcription / endocardial cell differentiation / epithelial to mesenchymal transition involved in endocardial cushion formation / response to transforming growth factor beta / secondary palate development / FOXO-mediated transcription of cell cycle genes / negative regulation of cardiac muscle hypertrophy / brainstem development / left ventricular cardiac muscle tissue morphogenesis / Transcriptional regulation of pluripotent stem cells / regulation of transforming growth factor beta receptor signaling pathway / atrioventricular canal development / cardiac conduction system development / positive regulation of extracellular matrix assembly / Germ layer formation at gastrulation / sulfate binding / Signaling by BMP / cellular response to BMP stimulus / Formation of definitive endoderm / outflow tract septum morphogenesis / activin receptor signaling pathway / Signaling by Activin / SMAD protein signal transduction / Signaling by NODAL / cardiac muscle hypertrophy in response to stress / gastrulation with mouth forming second / I-SMAD binding / neural crest cell differentiation / endothelial cell activation / Cardiogenesis / RUNX3 regulates CDKN1A transcription / embryonic digit morphogenesis / branching involved in ureteric bud morphogenesis / adrenal gland development / ventricular septum morphogenesis / interleukin-6-mediated signaling pathway / seminiferous tubule development / positive regulation of cardiac muscle cell apoptotic process / positive regulation of transforming growth factor beta receptor signaling pathway / TGF-beta receptor signaling activates SMADs / R-SMAD binding / uterus development / positive regulation of SMAD protein signal transduction / developmental growth / single fertilization / epithelial to mesenchymal transition / anatomical structure morphogenesis / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / BMP signaling pathway / positive regulation of epithelial to mesenchymal transition / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / extrinsic apoptotic signaling pathway / ovarian follicle development / cellular response to transforming growth factor beta stimulus / collagen binding / ERK1 and ERK2 cascade / transforming growth factor beta receptor signaling pathway / transcription corepressor binding / cellular response to glucose stimulus / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / axon guidance / negative regulation of canonical Wnt signaling pathway / negative regulation of protein catabolic process / negative regulation of ERK1 and ERK2 cascade / negative regulation of cell growth / transcription coactivator binding / positive regulation of miRNA transcription / osteoblast differentiation / spermatogenesis / DNA-binding transcription activator activity, RNA polymerase II-specific / intracellular iron ion homeostasis / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / cell population proliferation / transcription regulator complex / sequence-specific DNA binding Similarity search - Function Smad3; Chain A / SMAD MH1 domain / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins ... Smad3; Chain A / SMAD MH1 domain / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / SMAD-like domain superfamily / SMAD/FHA domain superfamily / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.98 Å DetailsAuthors Kaczmarska, Z. / Freier, R. / Marquez, J.A. / Macias, M.J. CitationJournal : Nat Commun / Year : 2017Title : Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.Authors : Martin-Malpartida, P. / Batet, M. / Kaczmarska, Z. / Freier, R. / Gomes, T. / Aragon, E. / Zou, Y. / Wang, Q. / Xi, Q. / Ruiz, L. / Vea, A. / Marquez, J.A. / Massague, J. / Macias, M.J. History Deposition Nov 16, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 15, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Dec 27, 2017 Group : Database references / Category : citationItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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