Entry Database : PDB / ID : 5lge Structure visualization Downloads & linksTitle Crystal Structure of human IDH1 mutant (R132H) in complex with NADP+ and an Inhibitor related to BAY 1436032 ComponentsIsocitrate dehydrogenase [NADP] cytoplasmic Details Keywords OXIDOREDUCTASE / IDH1 / ALLOSTERIC INHIBITOR / NADP+Function / homology Function and homology informationFunction Domain/homology Component
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate / NADPH regeneration / regulation of phospholipid catabolic process / regulation of phospholipid biosynthetic process / NFE2L2 regulating TCA cycle genes / isocitrate metabolic process / isocitrate dehydrogenase (NADP+) / isocitrate dehydrogenase (NADP+) activity / 2-oxoglutarate metabolic process / NADP metabolic process ... Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate / NADPH regeneration / regulation of phospholipid catabolic process / regulation of phospholipid biosynthetic process / NFE2L2 regulating TCA cycle genes / isocitrate metabolic process / isocitrate dehydrogenase (NADP+) / isocitrate dehydrogenase (NADP+) activity / 2-oxoglutarate metabolic process / NADP metabolic process / glyoxylate cycle / response to steroid hormone / female gonad development / peroxisomal matrix / tricarboxylic acid cycle / glutathione metabolic process / Peroxisomal protein import / peroxisome / NAD binding / tertiary granule lumen / NADP binding / secretory granule lumen / ficolin-1-rich granule lumen / response to oxidative stress / cadherin binding / Neutrophil degranulation / magnesium ion binding / protein homodimerization activity / mitochondrion / extracellular exosome / extracellular region / identical protein binding / cytoplasm / cytosol Similarity search - Function Isocitrate dehydrogenase NADP-dependent / Isopropylmalate Dehydrogenase / Isopropylmalate Dehydrogenase / Isocitrate/isopropylmalate dehydrogenase, conserved site / Isocitrate and isopropylmalate dehydrogenases signature. / Isopropylmalate dehydrogenase-like domain / Isocitrate/isopropylmalate dehydrogenase / Isocitrate/isopropylmalate dehydrogenase / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homology Chem-6VN / ACETATE ION / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / Isocitrate dehydrogenase [NADP] cytoplasmic Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.7 Å DetailsAuthors Hillig, R.C. / Hars, U. / Korndoerfer, I.P. CitationJournal : Acta Neuropathol. / Year : 2017Title : Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.Authors: Pusch, S. / Krausert, S. / Fischer, V. / Balss, J. / Ott, M. / Schrimpf, D. / Capper, D. / Sahm, F. / Eisel, J. / Beck, A.C. / Jugold, M. / Eichwald, V. / Kaulfuss, S. / Panknin, O. / ... Authors : Pusch, S. / Krausert, S. / Fischer, V. / Balss, J. / Ott, M. / Schrimpf, D. / Capper, D. / Sahm, F. / Eisel, J. / Beck, A.C. / Jugold, M. / Eichwald, V. / Kaulfuss, S. / Panknin, O. / Rehwinkel, H. / Zimmermann, K. / Hillig, R.C. / Guenther, J. / Toschi, L. / Neuhaus, R. / Haegebart, A. / Hess-Stumpp, H. / Bauser, M. / Wick, W. / Unterberg, A. / Herold-Mende, C. / Platten, M. / von Deimling, A. History Deposition Jul 7, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Feb 8, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Mar 22, 2017 Group : Database referencesRevision 1.2 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _citation.country / _database_2.pdbx_DOI ... _citation.country / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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