登録情報 | データベース: PDB / ID: 5iy4 |
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タイトル | Crystal structure of human PCNA in complex with the PIP box of DVC1 |
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要素 | - DVC1 PIP box
- Proliferating cell nuclear antigen
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キーワード | DNA BINDING PROTEIN / PCNA / PIP box / DVC1 |
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機能・相同性 | 機能・相同性情報
positive regulation of deoxyribonuclease activity / dinucleotide insertion or deletion binding / PCNA-p21 complex / mitotic telomere maintenance via semi-conservative replication / purine-specific mismatch base pair DNA N-glycosylase activity / nuclear lamina / positive regulation of DNA-directed DNA polymerase activity / Polymerase switching / MutLalpha complex binding / Telomere C-strand (Lagging Strand) Synthesis ...positive regulation of deoxyribonuclease activity / dinucleotide insertion or deletion binding / PCNA-p21 complex / mitotic telomere maintenance via semi-conservative replication / purine-specific mismatch base pair DNA N-glycosylase activity / nuclear lamina / positive regulation of DNA-directed DNA polymerase activity / Polymerase switching / MutLalpha complex binding / Telomere C-strand (Lagging Strand) Synthesis / Processive synthesis on the lagging strand / PCNA complex / protein-DNA covalent cross-linking repair / Removal of the Flap Intermediate / Processive synthesis on the C-strand of the telomere / Polymerase switching on the C-strand of the telomere / Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) / Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) / Removal of the Flap Intermediate from the C-strand / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; その他のペプチターゼ / Transcription of E2F targets under negative control by DREAM complex / replisome / response to L-glutamate / K63-linked polyubiquitin modification-dependent protein binding / response to dexamethasone / histone acetyltransferase binding / DNA polymerase processivity factor activity / leading strand elongation / G1/S-Specific Transcription / nuclear replication fork / replication fork processing / protein autoprocessing / SUMOylation of DNA replication proteins / polyubiquitin modification-dependent protein binding / PCNA-Dependent Long Patch Base Excision Repair / response to cadmium ion / translesion synthesis / interstrand cross-link repair / mismatch repair / estrous cycle / response to UV / cyclin-dependent protein kinase holoenzyme complex / Translesion synthesis by REV1 / Translesion synthesis by POLK / base-excision repair, gap-filling / DNA polymerase binding / positive regulation of protein ubiquitination / Translesion synthesis by POLI / Gap-filling DNA repair synthesis and ligation in GG-NER / epithelial cell differentiation / liver regeneration / positive regulation of DNA repair / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / Termination of translesion DNA synthesis / positive regulation of DNA replication / ubiquitin binding / replication fork / Recognition of DNA damage by PCNA-containing replication complex / nuclear estrogen receptor binding / Translesion Synthesis by POLH / male germ cell nucleus / HDR through Homologous Recombination (HRR) / Dual Incision in GG-NER / receptor tyrosine kinase binding / metalloendopeptidase activity / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / cellular response to hydrogen peroxide / cellular response to xenobiotic stimulus / cellular response to UV / E3 ubiquitin ligases ubiquitinate target proteins / response to estradiol / single-stranded DNA binding / heart development / chromatin organization / double-stranded DNA binding / damaged DNA binding / chromosome, telomeric region / nuclear speck / nuclear body / centrosome / DNA damage response / chromatin binding / chromatin / protein-containing complex binding / enzyme binding / negative regulation of transcription by RNA polymerase II / proteolysis / extracellular exosome / zinc ion binding / nucleoplasm / identical protein binding / nucleus類似検索 - 分子機能 SprT-like / SprT-like domain-containing protein Spartan / : / SprT-like family / Spartan-like zinc binding domain / SprT homologues. / Rad18-like CCHC zinc finger / Box / Proliferating Cell Nuclear Antigen / Proliferating Cell Nuclear Antigen - #10 ...SprT-like / SprT-like domain-containing protein Spartan / : / SprT-like family / Spartan-like zinc binding domain / SprT homologues. / Rad18-like CCHC zinc finger / Box / Proliferating Cell Nuclear Antigen / Proliferating Cell Nuclear Antigen - #10 / Proliferating cell nuclear antigen signature 2. / Proliferating cell nuclear antigen, PCNA, conserved site / Proliferating cell nuclear antigen signature 1. / Proliferating cell nuclear antigen, PCNA / Proliferating cell nuclear antigen, PCNA, N-terminal / Proliferating cell nuclear antigen, PCNA, C-terminal / Proliferating cell nuclear antigen, N-terminal domain / Proliferating cell nuclear antigen, C-terminal domain / Rad18, zinc finger UBZ4-type / Zinc finger UBZ4-type profile. / : / Neutral zinc metallopeptidases, zinc-binding region signature. / Alpha Beta類似検索 - ドメイン・相同性 Proliferating cell nuclear antigen / DNA-dependent metalloprotease SPRTN類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.945 Å |
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データ登録者 | Jiang, T. / Xu, M. / Wang, Y. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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Strategic Priority Research Program | XDB08010301 | 中国 |
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引用 | ジャーナル: Biochem.Biophys.Res.Commun. / 年: 2016 タイトル: Crystal structure of human PCNA in complex with the PIP box of DVC1 著者: Wang, Y. / Xu, M. / Jiang, T. |
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履歴 | 登録 | 2016年3月24日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2016年6月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年9月27日 | Group: Data collection / Derived calculations / カテゴリ: diffrn_detector / pdbx_struct_oper_list Item: _diffrn_detector.detector / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.2 | 2023年11月8日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.3 | 2024年10月30日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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