Entry | Database: PDB / ID: 5iq7 |
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Title | Crystal structure of 10E8-S74W Fab in complex with an HIV-1 gp41 peptide. |
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Components | - 10E8-S74W Heavy Chain
- 10E8-S74W Light Chain
- gp41 MPER peptide
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Keywords | IMMUNE SYSTEM / Immunoglobulin / MPER / Antibody |
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Function / homology | Function and homology information
: / IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / IgE immunoglobulin complex / positive regulation of B cell activation / phagocytosis, recognition / Fc-gamma receptor I complex binding / CD22 mediated BCR regulation / complement-dependent cytotoxicity ...: / IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / IgE immunoglobulin complex / positive regulation of B cell activation / phagocytosis, recognition / Fc-gamma receptor I complex binding / CD22 mediated BCR regulation / complement-dependent cytotoxicity / IgG immunoglobulin complex / Fc epsilon receptor (FCERI) signaling / antibody-dependent cellular cytotoxicity / Classical antibody-mediated complement activation / phagocytosis, engulfment / Initial triggering of complement / FCGR activation / Role of phospholipids in phagocytosis / Role of LAT2/NTAL/LAB on calcium mobilization / Scavenging of heme from plasma / positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / immunoglobulin complex, circulating / immunoglobulin receptor binding / positive regulation of establishment of T cell polarity / FCERI mediated Ca+2 mobilization / FCGR3A-mediated IL10 synthesis / host cell endosome membrane / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / complement activation, classical pathway / Regulation of Complement cascade / Cell surface interactions at the vascular wall / FCERI mediated MAPK activation / FCGR3A-mediated phagocytosis / antigen binding / B cell receptor signaling pathway / Regulation of actin dynamics for phagocytic cup formation / FCERI mediated NF-kB activation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / antibacterial humoral response / Interleukin-4 and Interleukin-13 signaling / clathrin-dependent endocytosis of virus by host cell / adaptive immune response / viral protein processing / blood microparticle / defense response to bacterium / fusion of virus membrane with host plasma membrane / external side of plasma membrane / innate immune response / virus-mediated perturbation of host defense response / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / host cell plasma membrane / structural molecule activity / virion membrane / extracellular space / extracellular exosome / extracellular region / plasma membraneSimilarity search - Function Envelope glycoprotein Gp160 / Retroviral envelope protein / Retroviral envelope protein GP41-like / Gp120 core superfamily / Envelope glycoprotein GP120 / Human immunodeficiency virus 1, envelope glycoprotein Gp120 / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set ...Envelope glycoprotein Gp160 / Retroviral envelope protein / Retroviral envelope protein GP41-like / Gp120 core superfamily / Envelope glycoprotein GP120 / Human immunodeficiency virus 1, envelope glycoprotein Gp120 / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human)
![](img/tx_virus.gif) Human immunodeficiency virus 1 |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.2869 Å |
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Authors | Ofek, G. / Kwon, Y.D. / Caruso, W. / Kwong, P.D. |
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Funding support | United States, 2items Organization | Grant number | Country |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | | United States | Bill & Melinda Gates Foundation | | United States |
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Citation | Journal: J.Virol. / Year: 2016 Title: Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design. Authors: Kwon, Y.D. / Georgiev, I.S. / Ofek, G. / Zhang, B. / Asokan, M. / Bailer, R.T. / Bao, A. / Caruso, W. / Chen, X. / Choe, M. / Druz, A. / Ko, S.Y. / Louder, M.K. / McKee, K. / O'Dell, S. / ...Authors: Kwon, Y.D. / Georgiev, I.S. / Ofek, G. / Zhang, B. / Asokan, M. / Bailer, R.T. / Bao, A. / Caruso, W. / Chen, X. / Choe, M. / Druz, A. / Ko, S.Y. / Louder, M.K. / McKee, K. / O'Dell, S. / Pegu, A. / Rudicell, R.S. / Shi, W. / Wang, K. / Yang, Y. / Alger, M. / Bender, M.F. / Carlton, K. / Cooper, J.W. / Blinn, J. / Eudailey, J. / Lloyd, K. / Parks, R. / Alam, S.M. / Haynes, B.F. / Padte, N.N. / Yu, J. / Ho, D.D. / Huang, J. / Connors, M. / Schwartz, R.M. / Mascola, J.R. / Kwong, P.D. |
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History | Deposition | Mar 10, 2016 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Apr 20, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Apr 27, 2016 | Group: Source and taxonomy |
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Revision 1.2 | Jun 22, 2016 | Group: Database references |
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Revision 1.3 | Sep 6, 2017 | Group: Author supporting evidence / Database references / Derived calculations Category: citation / pdbx_audit_support / pdbx_struct_oper_list Item: _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
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Revision 1.4 | Mar 23, 2022 | Group: Author supporting evidence / Database references / Category: database_2 / pdbx_audit_support Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_audit_support.funding_organization |
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Revision 1.5 | Sep 27, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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