登録情報 | データベース: PDB / ID: 5hyu |
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タイトル | Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M2 protein |
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要素 | - C4b-binding protein alpha chain
- M protein, serotype 2.1
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キーワード | IMMUNE SYSTEM / M protein / Complement / Streptococcus pyogenes / hypervariable antigen |
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機能・相同性 | 機能・相同性情報
regulation of opsonization / response to symbiotic bacterium / negative regulation of complement activation, classical pathway / T cell mediated immunity / phagocytosis / complement activation, classical pathway / Regulation of Complement cascade / positive regulation of protein catabolic process / blood microparticle / innate immune response ...regulation of opsonization / response to symbiotic bacterium / negative regulation of complement activation, classical pathway / T cell mediated immunity / phagocytosis / complement activation, classical pathway / Regulation of Complement cascade / positive regulation of protein catabolic process / blood microparticle / innate immune response / RNA binding / extracellular space / extracellular region / plasma membrane類似検索 - 分子機能 C4b-binding protein alpha, oligomerization domain / Oligomerization domain of C4b-binding protein alpha / M protein repeat / M protein repeat / : / M protein-type anchor domain / Complement Module, domain 1 / Complement Module; domain 1 / YSIRK type signal peptide / Sushi repeat (SCR repeat) ...C4b-binding protein alpha, oligomerization domain / Oligomerization domain of C4b-binding protein alpha / M protein repeat / M protein repeat / : / M protein-type anchor domain / Complement Module, domain 1 / Complement Module; domain 1 / YSIRK type signal peptide / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / YSIRK Gram-positive signal peptide / LPXTG cell wall anchor motif / Gram-positive cocci surface proteins LPxTG motif profile. / LPXTG cell wall anchor domain / Ribbon / Mainly Beta類似検索 - ドメイン・相同性 C4b-binding protein alpha chain / M protein, serotype 2.1類似検索 - 構成要素 |
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生物種 | Streptococcus pyogenes (化膿レンサ球菌) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 単波長異常分散 / 解像度: 2.561 Å |
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データ登録者 | Buffalo, C.Z. / Bahn-Suh, A.J. / Ghosh, P. |
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資金援助 | 米国, 4件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | T32 GM007240 | 米国 | American Heart Association | 14PRE18320032 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01 AI096837 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01 AI077780 | 米国 |
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引用 | ジャーナル: Nat Microbiol / 年: 2016 タイトル: Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. 著者: Buffalo, C.Z. / Bahn-Suh, A.J. / Hirakis, S.P. / Biswas, T. / Amaro, R.E. / Nizet, V. / Ghosh, P. |
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履歴 | 登録 | 2016年2月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年7月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年10月26日 | Group: Database references |
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改定 1.2 | 2017年9月13日 | Group: Author supporting evidence / Derived calculations / カテゴリ: pdbx_audit_support / pdbx_struct_oper_list Item: _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.3 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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