Entry Database : PDB / ID : 5glh Structure visualization Downloads & linksTitle Human endothelin receptor type-B in complex with ET-1 ComponentsEndothelin Receptor Subtype-B Peptide from Endothelin-1 DetailsKeywords SIGNALING PROTEIN / alpha helicalFunction / homology Function and homology informationFunction Domain/homology Component
enteric smooth muscle cell differentiation / response to endothelin / endothelin receptor activity / negative regulation of neuron maturation / aldosterone metabolic process / positive regulation of prostaglandin-endoperoxide synthase activity / endothelin A receptor binding / protein kinase C deactivation / cellular response to human chorionic gonadotropin stimulus / chordate pharynx development ... enteric smooth muscle cell differentiation / response to endothelin / endothelin receptor activity / negative regulation of neuron maturation / aldosterone metabolic process / positive regulation of prostaglandin-endoperoxide synthase activity / endothelin A receptor binding / protein kinase C deactivation / cellular response to human chorionic gonadotropin stimulus / chordate pharynx development / meiotic cell cycle process involved in oocyte maturation / phospholipase D-activating G protein-coupled receptor signaling pathway / rhythmic excitation / endothelin B receptor binding / peptide hormone secretion / neural crest cell fate commitment / sympathetic neuron axon guidance / positive regulation of artery morphogenesis / glomerular endothelium development / vein smooth muscle contraction / body fluid secretion / regulation of fever generation / noradrenergic neuron differentiation / response to prostaglandin F / positive regulation of sarcomere organization / leukocyte activation / positive regulation of renal sodium excretion / histamine secretion / heparin metabolic process / positive regulation of chemokine-mediated signaling pathway / maternal process involved in parturition / positive regulation of penile erection / neuroblast migration / rough endoplasmic reticulum lumen / pharyngeal arch artery morphogenesis / regulation of glucose transmembrane transport / posterior midgut development / positive regulation of odontogenesis / endothelin receptor signaling pathway involved in heart process / epithelial fluid transport / cardiac neural crest cell migration involved in outflow tract morphogenesis / negative regulation of hormone secretion / response to leptin / endothelin receptor signaling pathway / Weibel-Palade body / developmental pigmentation / podocyte differentiation / response to ozone / renal sodium ion absorption / protein transmembrane transport / glomerular filtration / positive regulation of cell growth involved in cardiac muscle cell development / artery smooth muscle contraction / response to sodium phosphate / enteric nervous system development / axonogenesis involved in innervation / positive regulation of cation channel activity / renal sodium excretion / renin secretion into blood stream / cellular response to follicle-stimulating hormone stimulus / positive regulation of prostaglandin secretion / cellular response to luteinizing hormone stimulus / melanocyte differentiation / renal albumin absorption / negative regulation of nitric-oxide synthase biosynthetic process / cellular response to mineralocorticoid stimulus / basal part of cell / respiratory gaseous exchange by respiratory system / positive regulation of urine volume / positive regulation of smooth muscle contraction / response to salt / regulation of pH / semaphorin-plexin signaling pathway involved in axon guidance / negative regulation of adenylate cyclase activity / peripheral nervous system development / positive regulation of hormone secretion / regulation of systemic arterial blood pressure by endothelin / vasoconstriction / : / regulation of epithelial cell proliferation / embryonic heart tube development / negative regulation of blood coagulation / type 1 angiotensin receptor binding / dorsal/ventral pattern formation / establishment of endothelial barrier / axon extension / superoxide anion generation / positive regulation of neutrophil chemotaxis / positive regulation of signaling receptor activity / cartilage development / middle ear morphogenesis / cellular response to glucocorticoid stimulus / neural crest cell migration / prostaglandin biosynthetic process / negative regulation of protein metabolic process / nitric oxide transport / cellular response to fatty acid / branching involved in blood vessel morphogenesis / response to pain / positive regulation of heart rate Similarity search - Function Endothelin receptor B / Endothelin receptor family / Endothelin-like toxin / Endothelin-like toxin, conserved site / Endothelin / Endothelin family / Endothelin family signature. / Endothelin / Phage lysozyme / Serpentine type 7TM GPCR chemoreceptor Srsx ... Endothelin receptor B / Endothelin receptor family / Endothelin-like toxin / Endothelin-like toxin, conserved site / Endothelin / Endothelin family / Endothelin family signature. / Endothelin / Phage lysozyme / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.8 Å DetailsAuthors Shihoya, W. / Nishizawa, T. / Okuta, A. / Tani, K. / Fujiyoshi, Y. / Dohmae, N. / Nureki, O. / Doi, T. CitationJournal : Nature / Year : 2016Title : Activation mechanism of endothelin ETB receptor by endothelin-1.Authors : Shihoya, W. / Nishizawa, T. / Okuta, A. / Tani, K. / Dohmae, N. / Fujiyoshi, Y. / Nureki, O. / Doi, T. History Deposition Jul 11, 2016 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Sep 7, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Sep 21, 2016 Group : Database references / Structure summaryRevision 1.2 Sep 28, 2016 Group : Database referencesRevision 1.3 Feb 26, 2020 Group : Data collection / Database references / Derived calculationsCategory : citation / diffrn_source / pdbx_struct_oper_listItem : _citation.journal_id_CSD / _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operation
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