登録情報 データベース : PDB / ID : 5fuc 構造の表示 ダウンロードとリンクタイトル Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies 要素INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-6 RECEPTOR INTERLEUKIN-6 インターロイキン-6 VHH6 詳細キーワード IMMUNE SYSTEM (免疫系) / VHH / IL-6 / IL-6 RECEPTOR ALPHA / IL-6 RECEPTOR BETA / GP80 / ANTIBODY (抗体) / JUNCTIONAL EPITOPE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
ciliary neurotrophic factor binding / positive regulation of interleukin-21 production / regulation of astrocyte activation / glucagon secretion / regulation of glucagon secretion / negative regulation of interleukin-1-mediated signaling pathway / hepatic immune response / regulation of vascular endothelial growth factor production / negative regulation of primary miRNA processing / T follicular helper cell differentiation ... ciliary neurotrophic factor binding / positive regulation of interleukin-21 production / regulation of astrocyte activation / glucagon secretion / regulation of glucagon secretion / negative regulation of interleukin-1-mediated signaling pathway / hepatic immune response / regulation of vascular endothelial growth factor production / negative regulation of primary miRNA processing / T follicular helper cell differentiation / interleukin-11 receptor activity / interleukin-11 binding / interleukin-6 receptor activity / interleukin-6 binding / germinal center B cell differentiation / ciliary neurotrophic factor receptor complex / regulation of microglial cell activation / ciliary neurotrophic factor-mediated signaling pathway / interleukin-6 receptor complex / positive regulation of extracellular matrix disassembly / positive regulation of type B pancreatic cell apoptotic process / positive regulation of receptor signaling pathway via STAT / positive regulation of apoptotic DNA fragmentation / response to peptidoglycan / hepatocyte proliferation / neutrophil apoptotic process / interleukin-6 receptor binding / negative regulation of collagen biosynthetic process / positive regulation of activation of Janus kinase activity / inflammatory response to wounding / T-helper 17 cell lineage commitment / positive regulation of T-helper 2 cell cytokine production / positive regulation of B cell activation / positive regulation of glomerular mesangial cell proliferation / endocrine pancreas development / negative regulation of interleukin-8 production / positive regulation of acute inflammatory response / regulation of neuroinflammatory response / vascular endothelial growth factor production / negative regulation of chemokine production / positive regulation of neuroinflammatory response / positive regulation of platelet aggregation / neutrophil mediated immunity / positive regulation of cytokine production involved in inflammatory response / negative regulation of bone resorption / positive regulation of leukocyte chemotaxis / positive regulation of leukocyte adhesion to vascular endothelial cell / CD163 mediating an anti-inflammatory response / cytokine receptor activity / positive regulation of immunoglobulin production / maintenance of blood-brain barrier / interleukin-6-mediated signaling pathway / Interleukin-6 signaling / negative regulation of fat cell differentiation / positive regulation of interleukin-17 production / MAPK3 (ERK1) activation / Interleukin-10 signaling / monocyte chemotaxis / MAPK1 (ERK2) activation / regulation of insulin secretion / positive regulation of interleukin-10 production / 液性免疫 / negative regulation of lipid storage / Transcriptional Regulation by VENTX / positive regulation of vascular endothelial growth factor production / regulation of angiogenesis / positive regulation of osteoblast differentiation / positive regulation of epithelial to mesenchymal transition / extrinsic apoptotic signaling pathway / positive regulation of T cell proliferation / positive regulation of chemokine production / response to glucocorticoid / positive regulation of glial cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / response to activity / positive regulation of interleukin-1 beta production / response to cytokine / cytokine activity / acute-phase response / positive regulation of translation / positive regulation of interleukin-8 production / liver regeneration / Post-translational protein phosphorylation / positive regulation of smooth muscle cell proliferation / positive regulation of receptor signaling pathway via JAK-STAT / growth factor activity / 凝固・線溶系 / cellular response to virus / cytokine-mediated signaling pathway / positive regulation of DNA-binding transcription factor activity / negative regulation of neurogenesis / cellular response to hydrogen peroxide / ADORA2B mediated anti-inflammatory cytokines production / neuron cellular homeostasis / Transcriptional regulation of granulopoiesis / positive regulation of interleukin-6 production / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / neuron projection development / positive regulation of tumor necrosis factor production / positive regulation of peptidyl-tyrosine phosphorylation 類似検索 - 分子機能 インターロイキン-6 / Interleukin-6/G-CSF/MGF family / Interleukin-6/GCSF/MGF, conserved site / Interleukin-6 / G-CSF / MGF signature. / Interleukin-6/GCSF/MGF / Interleukin-6 homologues / Type I cytokine receptor, cytokine-binding domain / Interleukin-6 receptor alpha chain, binding / Long hematopoietin receptor, soluble alpha chain, conserved site / Long hematopoietin receptor, soluble alpha chains family signature. ... インターロイキン-6 / Interleukin-6/G-CSF/MGF family / Interleukin-6/GCSF/MGF, conserved site / Interleukin-6 / G-CSF / MGF signature. / Interleukin-6/GCSF/MGF / Interleukin-6 homologues / Type I cytokine receptor, cytokine-binding domain / Interleukin-6 receptor alpha chain, binding / Long hematopoietin receptor, soluble alpha chain, conserved site / Long hematopoietin receptor, soluble alpha chains family signature. / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / 抗体 / 免疫グロブリンフォールド / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin subtype / 抗体 / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / 抗体 / Immunoglobulin-like fold / Up-down Bundle / Immunoglobulin-like / サンドイッチ / Mainly Beta / Mainly Alpha 類似検索 - ドメイン・相同性 Interleukin-6 receptor subunit alpha / インターロイキン-6 / Interleukin-6 receptor subunit alpha 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)CAMELUS DROMEDARIUS (ヒトコブラクダ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.7 Å 詳細データ登録者 Adams, R. / Griffin, R. / Doyle, C. / Ettorre, A. 引用ジャーナル : Sci Rep / 年 : 2017タイトル : Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.著者: Adams, R. / Burnley, R.J. / Valenzano, C.R. / Qureshi, O. / Doyle, C. / Lumb, S. / Del Carmen Lopez, M. / Griffin, R. / McMillan, D. / Taylor, R.D. / Meier, C. / Mori, P. / Griffin, L.M. / ... 著者 : Adams, R. / Burnley, R.J. / Valenzano, C.R. / Qureshi, O. / Doyle, C. / Lumb, S. / Del Carmen Lopez, M. / Griffin, R. / McMillan, D. / Taylor, R.D. / Meier, C. / Mori, P. / Griffin, L.M. / Wernery, U. / Kinne, J. / Rapecki, S. / Baker, T.S. / Lawson, A.D. / Wright, M. / Ettorre, A. 履歴 登録 2016年1月25日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2017年1月25日 Provider : repository / タイプ : Initial release改定 1.1 2017年3月1日 Group : Database references改定 1.2 2019年4月3日 Group : Advisory / Data collection ... Advisory / Data collection / Derived calculations / Source and taxonomy カテゴリ : entity_src_gen / pdbx_seq_map_depositor_info ... entity_src_gen / pdbx_seq_map_depositor_info / pdbx_unobs_or_zero_occ_atoms / struct_conn Item : _entity_src_gen.pdbx_host_org_cell_line / _pdbx_seq_map_depositor_info.one_letter_code ... _entity_src_gen.pdbx_host_org_cell_line / _pdbx_seq_map_depositor_info.one_letter_code / _pdbx_seq_map_depositor_info.one_letter_code_mod / _struct_conn.pdbx_leaving_atom_flag 改定 1.3 2020年7月29日 Group : Data collection / Derived calculations ... Data collection / Derived calculations / Other / Structure summary カテゴリ : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_database_status / pdbx_entity_nonpoly / reflns_shell / struct_conn / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_database_status.status_code_sf / _pdbx_entity_nonpoly.name / _reflns_shell.Rmerge_I_obs / _struct_conn.pdbx_role 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 1.4 2024年1月10日 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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