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TitleDiscovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Journal, issue, pagesSci Rep, Vol. 7, Page 37716-37716, Year 2017
Publish dateJan 25, 2016 (structure data deposition date)
AuthorsAdams, R. / Burnley, R.J. / Valenzano, C.R. / Qureshi, O. / Doyle, C. / Lumb, S. / Del Carmen Lopez, M. / Griffin, R. / McMillan, D. / Taylor, R.D. ...Adams, R. / Burnley, R.J. / Valenzano, C.R. / Qureshi, O. / Doyle, C. / Lumb, S. / Del Carmen Lopez, M. / Griffin, R. / McMillan, D. / Taylor, R.D. / Meier, C. / Mori, P. / Griffin, L.M. / Wernery, U. / Kinne, J. / Rapecki, S. / Baker, T.S. / Lawson, A.D. / Wright, M. / Ettorre, A.
External linksSci Rep / PubMed:28134246
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-5fuc:
Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-HOH:
WATER / Water

Source
  • homo sapiens (human)
  • camelus dromedarius (Arabian camel)
KeywordsIMMUNE SYSTEM / VHH / IL-6 / IL-6 RECEPTOR ALPHA / IL-6 RECEPTOR BETA / GP80 / ANTIBODY / JUNCTIONAL EPITOPE

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