Entry | Database: PDB / ID: 5foc |
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Title | Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P21) |
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Components | LEUCYL-TRNA SYNTHETASE |
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Keywords | LIGASE / P.FALCIPARUM / LEUCINE-TRNA LIGASE (LEURS) ACTIVITY / ATP + L-LEUCINE + TRNA(LEUCINE) GIVES AMP + DIPHOSPHATE + L-LEUCYL-TRNA(LEUCINE) / AMINOACYL-TRNA SYNTHETASE / PROTEIN BIOSYNTHESIS / NOVEL BORON INHIBITORS OF LEURS |
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Function / homology | Function and homology information
leucine-tRNA ligase / leucine-tRNA ligase activity / leucyl-tRNA aminoacylation / aminoacyl-tRNA editing activity / ATP binding / cytoplasmSimilarity search - Function Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic / Aminoacyl-tRNA synthetase, class Ia / tRNA synthetases class I (I, L, M and V) / Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain / Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding / Anticodon-binding domain of tRNA ligase / Aminoacyl-tRNA synthetase, class Ia, anticodon-binding / Aminoacyl-tRNA synthetase, class I, conserved site / Aminoacyl-transfer RNA synthetases class-I signature. / Rossmann-like alpha/beta/alpha sandwich foldSimilarity search - Domain/homology |
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Biological species | ![](img/tx_eukaryote.gif) PLASMODIUM FALCIPARUM (malaria parasite P. falciparum) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.5 Å |
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Authors | Palencia, A. / Sonoiki, E. / Guo, D. / Ahyong, V. / Dong, C. / Li, X. / Hernandez, V.S. / Gut, J. / Legac, J. / Cooper, R. ...Palencia, A. / Sonoiki, E. / Guo, D. / Ahyong, V. / Dong, C. / Li, X. / Hernandez, V.S. / Gut, J. / Legac, J. / Cooper, R. / Alley, M.R.K. / Freund, Y.R. / DeRisi, J. / Cusack, S. / Rosenthal, P.J. |
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Citation | Journal: Antimicrob.Agents Chemother. / Year: 2016 Title: Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Authors: Sonoiki, E. / Palencia, A. / Guo, D. / Ahyong, V. / Dong, C. / Li, X. / Hernandez, V.S. / Zhang, Y.K. / Choi, W. / Gut, J. / Legac, J. / Cooper, R. / Alley, M.R. / Freund, Y.R. / Derisi, J. ...Authors: Sonoiki, E. / Palencia, A. / Guo, D. / Ahyong, V. / Dong, C. / Li, X. / Hernandez, V.S. / Zhang, Y.K. / Choi, W. / Gut, J. / Legac, J. / Cooper, R. / Alley, M.R. / Freund, Y.R. / Derisi, J. / Cusack, S. / Rosenthal, P.J. |
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History | Deposition | Nov 19, 2015 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jun 22, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 10, 2016 | Group: Database references |
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Revision 1.2 | Sep 27, 2017 | Group: Data collection / Category: diffrn_detector / Item: _diffrn_detector.type |
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Revision 1.3 | May 1, 2024 | Group: Data collection / Database references ...Data collection / Database references / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf |
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