Entry Database : PDB / ID : 5fyq Structure visualization Downloads & linksTitle Sirt2 in complex with a 13-mer trifluoroacetylated Ran peptide ComponentsNAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 RAN AA 31-43 DetailsKeywords HYDROLASE / SIRTUIN / KDAC / LYSINE-DEACETYLASE / LYSINE-ACETYLATION / GENETIC-CODE EXPANSIONFunction / homology Function and homology informationFunction Domain/homology Component
cellular response to caloric restriction / negative regulation of oligodendrocyte progenitor proliferation / cellular lipid catabolic process / negative regulation of striated muscle tissue development / NAD-dependent histone H4K16 deacetylase activity / positive regulation of meiotic nuclear division / positive regulation of attachment of spindle microtubules to kinetochore / NAD-dependent protein demyristoylase activity / NAD-dependent protein depalmitoylase activity / paranodal junction ... cellular response to caloric restriction / negative regulation of oligodendrocyte progenitor proliferation / cellular lipid catabolic process / negative regulation of striated muscle tissue development / NAD-dependent histone H4K16 deacetylase activity / positive regulation of meiotic nuclear division / positive regulation of attachment of spindle microtubules to kinetochore / NAD-dependent protein demyristoylase activity / NAD-dependent protein depalmitoylase activity / paranodal junction / tubulin deacetylation / lateral loop / NLRP3 inflammasome complex assembly / peptidyl-lysine deacetylation / mitotic nuclear membrane reassembly / negative regulation of NLRP3 inflammasome complex assembly / RNA nuclear export complex / tubulin deacetylase activity / pre-miRNA export from nucleus / snRNA import into nucleus / cellular response to mineralocorticoid stimulus / regulation of exit from mitosis / paranode region of axon / manchette / NAD-dependent protein lysine deacetylase activity / Schmidt-Lanterman incisure / positive regulation of fatty acid biosynthetic process / myelination in peripheral nervous system / rDNA heterochromatin formation / protein acetyllysine N-acetyltransferase / Regulation of cholesterol biosynthesis by SREBP (SREBF) / chromatin silencing complex / importin-alpha family protein binding / regulation of phosphorylation / Initiation of Nuclear Envelope (NE) Reformation / protein deacetylation / NAD-dependent histone deacetylase activity / positive regulation of oocyte maturation / juxtaparanode region of axon / protein localization to nucleolus / Rev-mediated nuclear export of HIV RNA / Nuclear import of Rev protein / protein lysine deacetylase activity / GTP metabolic process / NEP/NS2 Interacts with the Cellular Export Machinery / tRNA processing in the nucleus / meiotic spindle / Postmitotic nuclear pore complex (NPC) reformation / MicroRNA (miRNA) biogenesis / response to redox state / regulation of myelination / DNA metabolic process / dynein intermediate chain binding / histone acetyltransferase binding / histone deacetylase activity / negative regulation of fat cell differentiation / negative regulation of peptidyl-threonine phosphorylation / positive regulation of execution phase of apoptosis / mitotic sister chromatid segregation / glial cell projection / positive regulation of cell division / spermatid development / ribosomal large subunit export from nucleus / NAD+-protein poly-ADP-ribosyltransferase activity / NAD+ binding / subtelomeric heterochromatin formation / sperm flagellum / negative regulation of reactive oxygen species metabolic process / positive regulation of DNA binding / ribosomal small subunit export from nucleus / heterochromatin / ribosomal subunit export from nucleus / heterochromatin formation / nuclear pore / epigenetic regulation of gene expression / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / cellular response to epinephrine stimulus / substantia nigra development / centriole / protein export from nucleus / viral process / negative regulation of autophagy / mitotic spindle organization / G protein activity / meiotic cell cycle / ubiquitin binding / male germ cell nucleus / hippocampus development / Transcriptional regulation by small RNAs / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / negative regulation of protein catabolic process / recycling endosome / mitotic spindle / autophagy / histone deacetylase binding / positive regulation of protein import into nucleus / spindle / protein import into nucleus / GDP binding / melanosome Similarity search - Function Sirtuin, class I / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / small GTPase Ran family profile. / Ran GTPase / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. ... Sirtuin, class I / SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / small GTPase Ran family profile. / Ran GTPase / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily / Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3 Å DetailsAuthors Knyphausen, P. / de Boor, S. / Scislowski, L. / Extra, A. / Baldus, L. / Schacherl, M. / Baumann, U. / Neundorf, I. / Lammers, M. CitationJournal : J.Biol.Chem. / Year : 2016Title : Insights Into Lysine-Deacetylation of Natively Folded Substrate Proteins by Sirtuins.Authors : Knyphausen, P. / De Boor, S. / Kuhlmann, N. / Scislowski, L. / Extra, A. / Baldus, L. / Schacherl, M. / Baumann, U. / Neundorf, I. / Lammers, M. History Deposition Mar 9, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 25, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jun 8, 2016 Group : Database referencesRevision 1.2 Jul 27, 2016 Group : Database referencesRevision 1.3 Aug 23, 2017 Group : Data collection / Category : diffrn_detector / Item : _diffrn_detector.typeRevision 1.4 Jan 10, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_conn_type / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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