登録情報 | データベース: PDB / ID: 5dv2 |
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タイトル | Crystal structure of human CNOT6L in complex with cytidine-5'-monophosphate |
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要素 | CCR4-NOT transcription complex subunit 6-like |
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キーワード | HYDROLASE / nuclease domain / deadenylase / INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
positive regulation of cytoplasmic mRNA processing body assembly / poly(A)-specific ribonuclease / poly(A)-specific ribonuclease activity / CCR4-NOT complex / nuclear-transcribed mRNA poly(A) tail shortening / Deadenylation of mRNA / M-decay: degradation of maternal mRNAs by maternally stored factors / regulatory ncRNA-mediated gene silencing / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / mRNA processing ...positive regulation of cytoplasmic mRNA processing body assembly / poly(A)-specific ribonuclease / poly(A)-specific ribonuclease activity / CCR4-NOT complex / nuclear-transcribed mRNA poly(A) tail shortening / Deadenylation of mRNA / M-decay: degradation of maternal mRNAs by maternally stored factors / regulatory ncRNA-mediated gene silencing / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / mRNA processing / regulation of translation / positive regulation of cell population proliferation / nucleus / metal ion binding / cytoplasm / cytosol類似検索 - 分子機能 CCR4-NOT transcription complex subunit 6-like / : / Deoxyribonuclease I; Chain A / Endonuclease/exonuclease/phosphatase / Endonuclease/exonuclease/phosphatase / Endonuclease/Exonuclease/phosphatase family / Endonuclease/exonuclease/phosphatase superfamily / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily ...CCR4-NOT transcription complex subunit 6-like / : / Deoxyribonuclease I; Chain A / Endonuclease/exonuclease/phosphatase / Endonuclease/exonuclease/phosphatase / Endonuclease/Exonuclease/phosphatase family / Endonuclease/exonuclease/phosphatase superfamily / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily / 4-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 CYTIDINE-5'-MONOPHOSPHATE / CCR4-NOT transcription complex subunit 6-like類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.07 Å |
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データ登録者 | Zhang, Q. / Bartlam, M. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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Ministry of Science & Technology 973 Project | 2014CB560709 | 中国 |
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引用 | ジャーナル: Febs Lett. / 年: 2016 タイトル: Structural basis for inhibition of the deadenylase activity of human CNOT6L 著者: Zhang, Q. / Yan, D. / Guo, E. / Ding, B. / Yang, W. / Liu, R. / Yamamoto, T. / Bartlam, M. |
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履歴 | 登録 | 2015年9月21日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2016年5月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年3月20日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_struct_oper_list Item: _citation.journal_id_CSD / _database_2.pdbx_DOI ..._citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation |
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