登録情報 データベース : PDB / ID : 5iwg 構造の表示 ダウンロードとリンクタイトル HDAC2 WITH LIGAND BRD4884 要素Histone deacetylase 2 詳細 キーワード HYDROLASE / HDAC HISTONE DEACETYLASE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of male mating behavior / protein de-2-hydroxyisobutyrylase activity / protein lysine delactylase activity / negative regulation of dendritic spine development / p75NTR negatively regulates cell cycle via SC1 / epidermal cell differentiation / histone decrotonylase activity / fungiform papilla formation / positive regulation of interleukin-1 production / behavioral response to ethanol ... positive regulation of male mating behavior / protein de-2-hydroxyisobutyrylase activity / protein lysine delactylase activity / negative regulation of dendritic spine development / p75NTR negatively regulates cell cycle via SC1 / epidermal cell differentiation / histone decrotonylase activity / fungiform papilla formation / positive regulation of interleukin-1 production / behavioral response to ethanol / NuRD complex / regulation of cell fate specification / negative regulation of transcription by competitive promoter binding / EGR2 and SOX10-mediated initiation of Schwann cell myelination / negative regulation of stem cell population maintenance / histone deacetylase activity, hydrolytic mechanism / ESC/E(Z) complex / histone deacetylase / regulation of stem cell differentiation / cardiac muscle hypertrophy / cellular response to dopamine / STAT3 nuclear events downstream of ALK signaling / protein lysine deacetylase activity / response to caffeine / 加水分解酵素; ペプチド以外のCN結合加水分解酵素; 鎖状アミドに作用 / embryonic digit morphogenesis / histone deacetylase activity / positive regulation of intracellular estrogen receptor signaling pathway / Notch-HLH transcription pathway / Sin3-type complex / positive regulation of stem cell population maintenance / eyelid development in camera-type eye / odontogenesis of dentin-containing tooth / dendrite development / response to amyloid-beta / positive regulation of proteolysis / RNA Polymerase I Transcription Initiation / positive regulation of oligodendrocyte differentiation / histone deacetylase complex / Regulation of MECP2 expression and activity / progesterone receptor signaling pathway / hair follicle placode formation / response to hyperoxia / NF-kappaB binding / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / positive regulation of epithelial to mesenchymal transition / cellular response to transforming growth factor beta stimulus / Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 / MECP2 regulates neuronal receptors and channels / Regulation of TP53 Activity through Acetylation / cellular response to retinoic acid / heat shock protein binding / SUMOylation of chromatin organization proteins / negative regulation of cell migration / response to amphetamine / Regulation of PTEN gene transcription / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / transcription coregulator binding / Regulation of endogenous retroelements by KRAB-ZFP proteins / response to nicotine / response to cocaine / Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) / HDACs deacetylate histones / negative regulation of transforming growth factor beta receptor signaling pathway / NOTCH1 Intracellular Domain Regulates Transcription / promoter-specific chromatin binding / circadian regulation of gene expression / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / NoRC negatively regulates rRNA expression / protein modification process / histone deacetylase binding / cellular response to hydrogen peroxide / positive regulation of tumor necrosis factor production / heterochromatin formation / negative regulation of neuron projection development / cellular response to heat / Factors involved in megakaryocyte development and platelet production / histone binding / response to lipopolysaccharide / Potential therapeutics for SARS / RNA polymerase II-specific DNA-binding transcription factor binding / chromosome, telomeric region / chromatin remodeling / response to xenobiotic stimulus / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / chromatin binding / negative regulation of apoptotic process / chromatin / positive regulation of DNA-templated transcription / enzyme binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / RNA binding / nucleoplasm / nucleus / cytoplasm 類似検索 - 分子機能 Histone deacetylase / Histone deacetylase domain / Arginase; Chain A / : / Histone deacetylase family / Histone deacetylase domain / Histone deacetylase domain superfamily / Histone deacetylase domain / Ureohydrolase domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 Chem-IWX / DI(HYDROXYETHYL)ETHER / 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE / TRIETHYLENE GLYCOL / Histone deacetylase 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.66 Å 詳細データ登録者 Steinbacher, S. 引用ジャーナル : Bioorg.Med.Chem. / 年 : 2016タイトル : Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.著者: Wagner, F.F. / Weiwer, M. / Steinbacher, S. / Schomburg, A. / Reinemer, P. / Gale, J.P. / Campbell, A.J. / Fisher, S.L. / Zhao, W.N. / Reis, S.A. / Hennig, K.M. / Thomas, M. / Muller, P. / ... 著者 : Wagner, F.F. / Weiwer, M. / Steinbacher, S. / Schomburg, A. / Reinemer, P. / Gale, J.P. / Campbell, A.J. / Fisher, S.L. / Zhao, W.N. / Reis, S.A. / Hennig, K.M. / Thomas, M. / Muller, P. / Jefson, M.R. / Fass, D.M. / Haggarty, S.J. / Zhang, Y.L. / Holson, E.B. 履歴 登録 2016年3月22日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年8月31日 Provider : repository / タイプ : Initial release改定 1.1 2024年3月6日 Group : Data collection / Database references / Derived calculationsカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_struct_oper_list / struct_conn Item : _citation.journal_id_CSD / _database_2.pdbx_DOI ... _citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
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