Entry Database : PDB / ID : 7kbg Structure visualization Downloads & linksTitle Structure of Human HDAC2 in complex with a 2-substituted benzamide inhibitor (compound 20) ComponentsHistone deacetylase 2 Details Keywords HYDROLASE/HYDROLASE INHIBITOR / HISTONE DEACETYLASE / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of male mating behavior / protein de-2-hydroxyisobutyrylase activity / negative regulation of peptidyl-lysine acetylation / protein lysine delactylase activity / p75NTR negatively regulates cell cycle via SC1 / epidermal cell differentiation / negative regulation of dendritic spine development / histone decrotonylase activity / fungiform papilla formation / negative regulation of MHC class II biosynthetic process ... positive regulation of male mating behavior / protein de-2-hydroxyisobutyrylase activity / negative regulation of peptidyl-lysine acetylation / protein lysine delactylase activity / p75NTR negatively regulates cell cycle via SC1 / epidermal cell differentiation / negative regulation of dendritic spine development / histone decrotonylase activity / fungiform papilla formation / negative regulation of MHC class II biosynthetic process / : / behavioral response to ethanol / positive regulation of interleukin-1 production / NuRD complex / negative regulation of transcription by competitive promoter binding / regulation of cell fate specification / EGR2 and SOX10-mediated initiation of Schwann cell myelination / negative regulation of stem cell population maintenance / ESC/E(Z) complex / histone H4K16 deacetylase activity, hydrolytic mechanism / histone H4K5 deacetylase activity, hydrolytic mechanism / histone H4K8 deacetylase activity, hydrolytic mechanism / histone H3K4 deacetylase activity, hydrolytic mechanism / histone H3K14 deacetylase activity, hydrolytic mechanism / histone H4K12 deacetylase activity, hydrolytic mechanism / cellular response to dopamine / regulation of stem cell differentiation / histone deacetylase / STAT3 nuclear events downstream of ALK signaling / cardiac muscle hypertrophy / histone H3K9 deacetylase activity, hydrolytic mechanism / tubulin deacetylase activity / protein lysine deacetylase activity / response to caffeine / Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides / embryonic digit morphogenesis / histone deacetylase activity / Notch-HLH transcription pathway / positive regulation of stem cell population maintenance / eyelid development in camera-type eye / Sin3-type complex / dendrite development / odontogenesis of dentin-containing tooth / response to amyloid-beta / positive regulation of proteolysis / RNA Polymerase I Transcription Initiation / Regulation of MECP2 expression and activity / histone deacetylase complex / positive regulation of oligodendrocyte differentiation / hair follicle placode formation / positive regulation of collagen biosynthetic process / NF-kappaB binding / response to hyperoxia / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 / positive regulation of epithelial to mesenchymal transition / MECP2 regulates neuronal receptors and channels / cellular response to transforming growth factor beta stimulus / cellular response to retinoic acid / Regulation of TP53 Activity through Acetylation / heat shock protein binding / response to amphetamine / SUMOylation of chromatin organization proteins / negative regulation of cell migration / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / Regulation of PTEN gene transcription / Regulation of endogenous retroelements by KRAB-ZFP proteins / Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) / promoter-specific chromatin binding / HDACs deacetylate histones / response to nicotine / negative regulation of transforming growth factor beta receptor signaling pathway / circadian regulation of gene expression / negative regulation of DNA-binding transcription factor activity / response to cocaine / protein modification process / NoRC negatively regulates rRNA expression / NOTCH1 Intracellular Domain Regulates Transcription / cellular response to hydrogen peroxide / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / histone deacetylase binding / heterochromatin formation / positive regulation of tumor necrosis factor production / negative regulation of neuron projection development / Factors involved in megakaryocyte development and platelet production / cellular response to heat / RNA polymerase II-specific DNA-binding transcription factor binding / response to lipopolysaccharide / histone binding / Potential therapeutics for SARS / chromosome, telomeric region / chromatin remodeling / response to xenobiotic stimulus / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / chromatin binding / negative regulation of apoptotic process / chromatin / positive regulation of DNA-templated transcription Similarity search - Function Histone deacetylase / : / Histone deacetylase family / Histone deacetylase domain / Histone deacetylase domain superfamily / Histone deacetylase domain / Ureohydrolase domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution : 1.26 Å DetailsAuthors Klein, D.J. / Liu, J. CitationJournal : Acs Med.Chem.Lett. / Year : 2020Title : Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group.Authors : Liu, J. / Yu, Y. / Kelly, J. / Sha, D. / Alhassan, A.B. / Yu, W. / Maletic, M.M. / Duffy, J.L. / Klein, D.J. / Holloway, M.K. / Carroll, S. / Howell, B.J. / Barnard, R.J.O. / Wolkenberg, S. / Kozlowski, J.A. History Deposition Oct 2, 2020 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 30, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Mar 6, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less